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<article xml:lang="KO" article-type="case-report">

<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Allergy Asthma Respir Dis</journal-id>
<journal-id journal-id-type="publisher-id">AARD</journal-id>
<journal-title-group>
<journal-title>Allergy, Asthma &#x0026; Respiratory Disease</journal-title>
</journal-title-group>
<issn pub-type="ppub">2288-0402</issn>
<issn pub-type="epub">2288-0410</issn>
<publisher>
<publisher-name>The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology</publisher-name>
</publisher>
</journal-meta>

<article-meta>
<article-id pub-id-type="doi">10.4168/aard.2020.8.1.36</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Identification of pulmonary paragonimiasis using Ziehl-Neelsen stain</article-title>
</title-group>

<contrib-group>

<contrib contrib-type="author">
<name>
<surname>Kim</surname>
<given-names>Won Chul</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Hahm</surname>
<given-names>Cho Rom</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Kim</surname>
<given-names>Il Tae</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Koo</surname>
<given-names>Jin Hoi</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>

<contrib contrib-type="author" corresp="yes">
<contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-4519-1042</contrib-id>
<name>
<surname>Jung</surname>
<given-names>Woo Jin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

</contrib-group>

<aff id="A1"><label>1</label>Department of Medicine, Gwangmyeong Sungae Hospital, Gwangmyeong, <country>Korea</country>.</aff>
<aff id="A2"><label>2</label>Department of Laboratory Medicine, Gwangmyeong Sungae Hospital, Gwangmyeong, <country>Korea</country>.</aff>
<aff id="A3"><label>3</label>Department of Radiology, Gwangmyeong Sungae Hospital, Gwangmyeong, <country>Korea</country>.</aff>

<author-notes>
<corresp>Correspondence to: Woo Jin Jung. Division of Pulmonary Medicine, Department of Medicine, Gwangmyeong Sungae Hospital, 36 Digital-ro, Gwangmyeong 14241, Korea. Tel: +82-2-2680-7114, Fax: +82-2-2680-7755, <email>us2001wj@naver.com</email></corresp>
</author-notes>

<pub-date pub-type="ppub">
<month>01</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>31</day>
<month>01</month>
<year>2020</year>
</pub-date>
<volume>8</volume>
<issue>1</issue>
<fpage>36</fpage>
<lpage>39</lpage>

<history>
<date date-type="received">
<day>07</day>
<month>08</month>
<year>2018</year>
</date>
<date date-type="rev-recd">
<day>18</day>
<month>09</month>
<year>2018</year>
</date>
<date date-type="accepted">
<day>01</day>
<month>10</month>
<year>2018</year>
</date>
</history>

<permissions>
<copyright-statement>&#x00A9; 2020 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder>The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">
<license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>).</license-p>
</license>
</permissions>

<abstract>
<p>Pulmonary paragonimiasis and tuberculosis are endemic in Asia, South America, and Africa. However, differential diagnosis among the diseases is difficult because they present with similar clinical symptoms and diagnostic features. Here, we report a case of pulmonary paragonimiasis that was identified using Ziehl-Neelsen stain after initially being assessed for pulmonary tuberculosis. Following anti-<italic>Paragonimus</italic> chemotherapy, the patient's symptoms, laboratory test results, and lung lesions improved. Thus, the identification of <italic>Paragonimus westermani</italic> using Ziehl-Neelsen stain can be considered in the diagnosis.</p>
</abstract>

<kwd-group>
<kwd>Pulmonary paragonimiasis</kwd>
<kwd>Pulmonary tuberculosis</kwd>
<kwd>Ziehl-Neelsen stain</kwd>
</kwd-group>

</article-meta>
</front>

<back>

<ref-list>

  <ref id="B1">
    <label>1</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Kagawa</surname>
          <given-names>FT</given-names>
        </name>
      </person-group>
      <article-title>Pulmonary paragonimiasis</article-title>
      <source>Semin Respir Infect</source>
      <year>1997</year>
      <volume>12</volume>
      <fpage>149</fpage>
      <lpage>158</lpage>
    </element-citation>
  </ref>

  <ref id="B2">
    <label>2</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Slesak</surname>
          <given-names>G</given-names>
        </name>
        <name>
          <surname>Inthalad</surname>
          <given-names>S</given-names>
        </name>
        <name>
          <surname>Basy</surname>
          <given-names>P</given-names>
        </name>
        <name>
          <surname>Keomanivong</surname>
          <given-names>D</given-names>
        </name>
        <name>
          <surname>Phoutsavath</surname>
          <given-names>O</given-names>
        </name>
        <name>
          <surname>Khampoui</surname>
          <given-names>S</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>Ziehl-Neelsen staining technique can diagnose paragonimiasis</article-title>
      <source>PLoS Negl Trop Dis</source>
      <year>2011</year>
      <volume>5</volume>
      <elocation-id>e1048</elocation-id>
    </element-citation>
  </ref>

  <ref id="B3">
    <label>3</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Sim</surname>
          <given-names>YS</given-names>
        </name>
        <name>
          <surname>Lee</surname>
          <given-names>JH</given-names>
        </name>
        <name>
          <surname>Hong</surname>
          <given-names>SC</given-names>
        </name>
        <name>
          <surname>Chang</surname>
          <given-names>JH</given-names>
        </name>
        <name>
          <surname>Kang</surname>
          <given-names>SR</given-names>
        </name>
        <name>
          <surname>Yang</surname>
          <given-names>HJ</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>Paragonimus westermani found in the tip of a little finger</article-title>
      <source>Intern Med</source>
      <year>2010</year>
      <volume>49</volume>
      <fpage>1645</fpage>
      <lpage>1648</lpage>
    </element-citation>
  </ref>

  <ref id="B4">
    <label>4</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Jeon</surname>
          <given-names>K</given-names>
        </name>
        <name>
          <surname>Koh</surname>
          <given-names>WJ</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>H</given-names>
        </name>
        <name>
          <surname>Kwon</surname>
          <given-names>OJ</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>TS</given-names>
        </name>
        <name>
          <surname>Lee</surname>
          <given-names>KS</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>Clinical features of recently diagnosed pulmonary paragonimiasis in Korea</article-title>
      <source>Chest</source>
      <year>2005</year>
      <volume>128</volume>
      <fpage>1423</fpage>
      <lpage>1430</lpage>
    </element-citation>
  </ref>

  <ref id="B5">
    <label>5</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Kim</surname>
          <given-names>TS</given-names>
        </name>
        <name>
          <surname>Han</surname>
          <given-names>J</given-names>
        </name>
        <name>
          <surname>Shim</surname>
          <given-names>SS</given-names>
        </name>
        <name>
          <surname>Jeon</surname>
          <given-names>K</given-names>
        </name>
        <name>
          <surname>Koh</surname>
          <given-names>WJ</given-names>
        </name>
        <name>
          <surname>Lee</surname>
          <given-names>I</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>Pleuropulmonary paragonimiasis: CT findings in 31 patients</article-title>
      <source>AJR Am J Roentgenol</source>
      <year>2005</year>
      <volume>185</volume>
      <fpage>616</fpage>
      <lpage>621</lpage>
    </element-citation>
  </ref>

  <ref id="B6">
    <label>6</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Sadun</surname>
          <given-names>EH</given-names>
        </name>
        <name>
          <surname>Buck</surname>
          <given-names>AA</given-names>
        </name>
      </person-group>
      <article-title>Paragonimiasis in South Korea--immunodiagnostic, epidemiologic, clinical, roentgenologic and therapeutic studies</article-title>
      <source>Am J Trop Med Hyg</source>
      <year>1960</year>
      <volume>9</volume>
      <fpage>562</fpage>
      <lpage>599</lpage>
    </element-citation>
  </ref>

  <ref id="B7">
    <label>7</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Diaz</surname>
          <given-names>JH</given-names>
        </name>
      </person-group>
      <article-title>Paragonimiasis acquired in the United States: native and nonnative species</article-title>
      <source>Clin Microbiol Rev</source>
      <year>2013</year>
      <volume>26</volume>
      <fpage>493</fpage>
      <lpage>504</lpage>
    </element-citation>
  </ref>

  <ref id="B8">
    <label>8</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Im</surname>
          <given-names>JG</given-names>
        </name>
        <name>
          <surname>Whang</surname>
          <given-names>HY</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>WS</given-names>
        </name>
        <name>
          <surname>Han</surname>
          <given-names>MC</given-names>
        </name>
        <name>
          <surname>Shim</surname>
          <given-names>YS</given-names>
        </name>
        <name>
          <surname>Cho</surname>
          <given-names>SY</given-names>
        </name>
      </person-group>
      <article-title>Pleuropulmonary paragonimiasis: radiologic findings in 71 patients</article-title>
      <source>AJR Am J Roentgenol</source>
      <year>1992</year>
      <volume>159</volume>
      <fpage>39</fpage>
      <lpage>43</lpage>
    </element-citation>
  </ref>

  <ref id="B9">
    <label>9</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Hwang</surname>
          <given-names>KE</given-names>
        </name>
        <name>
          <surname>Song</surname>
          <given-names>HY</given-names>
        </name>
        <name>
          <surname>Jung</surname>
          <given-names>JW</given-names>
        </name>
        <name>
          <surname>Oh</surname>
          <given-names>SJ</given-names>
        </name>
        <name>
          <surname>Yoon</surname>
          <given-names>KH</given-names>
        </name>
        <name>
          <surname>Park</surname>
          <given-names>DS</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>Pleural fluid characteristics of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis</article-title>
      <source>Korean J Intern Med</source>
      <year>2015</year>
      <volume>30</volume>
      <fpage>56</fpage>
      <lpage>61</lpage>
    </element-citation>
  </ref>

  <ref id="B10">
    <label>10</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Im</surname>
          <given-names>SH</given-names>
        </name>
        <name>
          <surname>Shin</surname>
          <given-names>SH</given-names>
        </name>
        <name>
          <surname>Song</surname>
          <given-names>MJ</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>JW</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>SJ</given-names>
        </name>
      </person-group>
      <article-title>A case of Paragonimiasis in the abdominal subcutaneous tissue with pleural effusion</article-title>
      <source>Tuberc Respir Dis</source>
      <year>2004</year>
      <volume>56</volume>
      <fpage>550</fpage>
      <lpage>554</lpage>
    </element-citation>
  </ref>

  <ref id="B11">
    <label>11</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Cho</surname>
          <given-names>SY</given-names>
        </name>
        <name>
          <surname>Lee</surname>
          <given-names>DK</given-names>
        </name>
        <name>
          <surname>Kang</surname>
          <given-names>SY</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>SI</given-names>
        </name>
      </person-group>
      <article-title>An epidemiological study of human paragonimiasis by means of micro-ELISA</article-title>
      <source>Kisaengchunghak Chapchi</source>
      <year>1983</year>
      <volume>21</volume>
      <fpage>246</fpage>
      <lpage>256</lpage>
    </element-citation>
  </ref>

  <ref id="B12">
    <label>12</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Kuzucu</surname>
          <given-names>A</given-names>
        </name>
      </person-group>
      <article-title>Parasitic diseases of the respiratory tract</article-title>
      <source>Curr Opin Pulm Med</source>
      <year>2006</year>
      <volume>12</volume>
      <fpage>212</fpage>
      <lpage>221</lpage>
    </element-citation>
  </ref>

</ref-list>

</back>

<floats-group>

<fig position="float" id="F1">
<label>Fig. 1</label>
<caption>
  <title>A sputum smear slide with Ziehl-Neelsen stain showed a reddish to brownish colored egg suspected of <italic>Paragonimus westermani</italic>. Magnification was 1,000&#x00D7; using oil immersion.</title>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="aard-8-36-g001"></graphic>
</fig>

<fig position="float" id="F2">
<label>Fig. 2</label>
<caption>
  <title>(A) The initial chest X-ray in lateral decubitus position shows a significant amount of left pleural effusion (arrows). (B) Chest X-ray obtained 1 month later shows that the pleural effusion is resolved.</title>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="aard-8-36-g002"></graphic>
</fig>

<fig position="float" id="F3">
<label>Fig. 3</label>
<caption>
  <title>Axial computed tomography (CT) scans reveal a focal area of consolidation containing tiny nodules in the upper left lobe (arrow) at the pulmonary window setting (A) and left pleural effusion (arrow) at the mediastinal window setting (C). (B, D) CT images obtained during the 3-month follow-up examination reveal improved lung lesions.</title>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="aard-8-36-g003"></graphic>
</fig>

</floats-group>

</article>