J Korean Ophthalmol Soc JKOS Journal of the Korean Ophthalmological Society 0378-6471 2092-9374 The Korean Ophthalmological Society 10.3341/jkos.2019.60.12.1339 Case Report Hemophilia A in a Female Patient with Recurrent Vitreous Hemorrhage Kim Hyun Joon MD Nam Meong Sik MD Choo Hun Ku MD PhD Kim Soo Han MD PhD Department of Ophthalmology, Yonsei University Wonju College of Medicine, Wonju, Korea. Address reprint requests to Soo Han Kim, MD, PhD. Department of Ophthalmology, Wonju Severance Christian Hospital, #20 Ilsan-ro, Wonju 20426, Korea. Tel: 82-33-741-1346, Fax: 82-33-741-0460, Dingo84@yonsei.ac.kr 12 2019 17 12 2019 60 12 1339 1343 20 06 2019 25 07 2019 29 11 2019 ©2019 The Korean Ophthalmological Society 2019 The Korean Ophthalmological Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose

To report a case of recurrent intraocular hemorrhage due to type A hemophilia in a female patient without any previous medical history.

 Case summary

A 51-year-old female patient without any previous medical history was referred to our clinic due to blurred vision in her left eye. Slit lamp microscopy of the anterior segment was nonspecific. Fundus examination revealed vitreous hemorrhage with retinal tear in her left eye. Vitrectomy and cataract surgery were performed. One day after surgery, hyphema and vitreous hemorrhage recurred. A coagulation disorder was suspected and further serological evaluation was conducted. Coagulation factor analyses showed that the activity of coagulation factors 8 and 12 decreased to 25% and 47%, respectively. Genetic sequence analyses were conducted, and a missense mutation of C6724G> A] was found in exon 25, and type A hemophilia was confirmed.

 Conclusions

In patients who tend to show persistent bleeding even after proper treatment, hematological evaluation including coagulation factor assays, and the possibility of rare diseases such as hemophilia should be considered.

 Coaguation factor VIII Hemophilia A Vitreous hemorrhage

The authors have no conflicts to disclose.

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