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<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article"><?properties open_access?><front><journal-meta><journal-id journal-id-type="nlm-ta">Hip Pelvis</journal-id><journal-id journal-id-type="iso-abbrev">Hip Pelvis</journal-id><journal-id journal-id-type="publisher-id">HP</journal-id><journal-title-group><journal-title>Hip &amp; Pelvis</journal-title></journal-title-group><issn pub-type="ppub">2287-3260</issn><issn pub-type="epub">2287-3279</issn><publisher><publisher-name>Korean Hip Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31501763</article-id><article-id pub-id-type="pmc">6726870</article-id><article-id pub-id-type="doi">10.5371/hp.2019.31.3.144</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Selecting Arthroplasty Fixation Approach Based on Greater Trochanter Fracture Type in Unstable Intertrochanteric Fractures</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Min-Wook</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1-hp-31-144"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-4959-1230</contrib-id><name><surname>Chung</surname><given-names>Young-Yool</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1-hp-31-144"/></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Sung-an</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1-hp-31-144"/></contrib><contrib contrib-type="author"><name><surname>Shim</surname><given-names>Seung-Woo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1-hp-31-144"/></contrib></contrib-group><aff id="A1-hp-31-144">Department of Orthopaedic Surgery, Kwangju Christian Hospital, Gwangju, <country>Korea</country>.</aff><author-notes><corresp>Address reprint request to Young-Yool Chung, MD. Department of Orthopaedic Surgery, Kwangju Christian Hospital, 37 Yangrim-ro, Nam-gu, Gwangju 61661, Korea. TEL: +82-62-650-5064, FAX: +82-62-650-5066, <email>wonderchung@naver.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>29</day><month>8</month><year>2019</year></pub-date><volume>31</volume><issue>3</issue><fpage>144</fpage><lpage>149</lpage><history><date date-type="received"><day>12</day><month>1</month><year>2019</year></date><date date-type="rev-recd"><day>21</day><month>5</month><year>2019</year></date><date date-type="accepted"><day>30</day><month>5</month><year>2019</year></date></history><permissions><copyright-statement>Copyright &#xA9; 2019 by Korean Hip Society</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Korean Hip Society</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0">http://creativecommons.org/licenses/by-nc/4.0</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Purpose</title><p>To evaluate the success rate of fixation approaches for greater trochanter (GT) fracture types in those with unstable intertrochnateric fractures.</p></sec><sec><title>Materials and Methods</title><p>Forty-four patients who underwent arthroplasty for unstable intertrochanteric fractures between January 2015 and November 2017 and followed-up more than six months were included in this study. The fractures of GT were classified into one of four types (i.e., A, B, C, and D) and fixed using either figure-8 wiring or cerclage wiring according to fracture type. Fractures were type A (n=7), type B (n=20), type C (n=6), and type D (n=11). Type A and B, which are fractures located above the inferior border of GT were fixed using figure-8 wiring and/or adding cerclage wiring. On the other hand, all type C and D fractures, which were located below the inferior border, were fixed using cerclage wiring. Fixation failure was defined as breakage of wire and progressive migration of GT fragment greater than 5 mm on follow-up radiographs.</p></sec><sec><title>Results</title><p>The most common GT fracture types were B and D, both of which are longitudinal fractures. The success rates of fixation were 85.7% (6 out of 7 cases) for the treatment of type A, 90.0% (18 out of 20 cases) for the treatment of type B, and 100% for the treatment of types C (6 out of 6 cases) and D (11 out of 11 cases).</p></sec><sec><title>Conclusion</title><p>We note high success rates following fixation methods were selected based on the GT fracture type.</p></sec></abstract><kwd-group><kwd>Intertrochanteric fracture</kwd><kwd>Hemiarthroplasty</kwd><kwd>Greater trochanter fracture</kwd><kwd>Fixation</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>Hip fractures are increasing in frequency, due in large part to a rapidly aging population<xref rid="B1-hp-31-144" ref-type="bibr">1</xref><xref rid="B2-hp-31-144" ref-type="bibr">2)</xref>. Intertrochanteric fractures in the elderly are mostly osteoporotic fractures in a form of a comminuted fracture in which the bone has broken into 3&#x2013;4 fragments in 30&#x2013;40% and unstable intertrochanteric fractures that affect to the posteromedial cortex<xref rid="B3-hp-31-144" ref-type="bibr">3</xref><xref rid="B4-hp-31-144" ref-type="bibr">4)</xref>. Hemiarthroplasty is one surgical treatment option for the management of unstable intertrochanteric fractures in older adults by allowing early ambulation after surgery, preventing several complications caused by prolonged bed rest, and having a positive effect on gait restoration<xref rid="B5-hp-31-144" ref-type="bibr">5</xref><xref rid="B6-hp-31-144" ref-type="bibr">6</xref><xref rid="B7-hp-31-144" ref-type="bibr">7)</xref>. Since fixation failure of the greater trochanteric fragment, the attachment site for the abductor muscles, may cause pain, limping and dislocation of the hip, a variety of fixation methods have been introduced to obtain solid fixation of bone fragments<xref rid="B8-hp-31-144" ref-type="bibr">8</xref><xref rid="B9-hp-31-144" ref-type="bibr">9</xref><xref rid="B10-hp-31-144" ref-type="bibr">10</xref><xref rid="B11-hp-31-144" ref-type="bibr">11</xref><xref rid="B12-hp-31-144" ref-type="bibr">12)</xref>. However, studies on the classification of greater trochanter (GT) fractures and fixation methods according to the type of GT fracture have been rarely performed. Here, we report a difference in the stability of the greater trochanteric fragment depending on the GT fracture types in our previous study<xref rid="B13-hp-31-144" ref-type="bibr">13)</xref>. For this reason, we hypothesized that bone fragments could be successfully fixed by choosing an appropriate fixation method according to fragment stability, and secondary surgery could be avoided by minimizing the risk of irritation in plate fixation. We aimed to investigate the success rate of fixation by altering fixation methods according to GT fracture types classified based on the fracture sites and the direction of the fracture.</p></sec><sec sec-type="materials|methods"><title>MATERIALS AND METHODS</title><p>Of 73 patients who underwent cementless bipolar hemiarthroplasty for the management of unstable intertrochanteric fractures rated AO/OTA type A2 or higher from January 2015 to November 2017 among patients aged over 65 years, a total of 44 patients were included in the study. Twenty-nine patients were excluded because they could not be followed-up for more than 6 months (n=15) and because they died during follow-up (n=14). Thirty-two and 12 patients were females and male, respectively, and the mean age was 81.3&#xB1;6.0 years. All fractures were caused by falls and the mean BMD T-score was &#x2212;3.6.</p><p>All operations were performed in a lateral position through a posterolateral approach by a single surgeon. Cementless femoral stems (Wagner SL revision Hip system<sup>&#xAE;</sup>; Zimmer, Warsaw, IN, USA) were used. GT fractures were classified into four types according to the site and direction of the fracture. Type A is a transverse fracture located above the inferior border of the GT and the fracture fragment tends to be displaced superiorly by the pulling force of the hip abductors attached to the fragment. Type B is defined as a vertical fracture that is extended above the inferior border of GT. Type C included transverse fractures below the inferior border of the GT. Type C fractures are likely to have relatively weak displacement of fracture fragments because of the abductors proximally and vastus lateralis distally attached to the fracture fragment. Type D fractures occur vertically and extend to below to inferior border of the GT (<xref ref-type="fig" rid="F1-hp-31-144">Fig. 1</xref>). After insertion of a femoral stem and bipolar cup, reduction of the hip was performed, fixation methods of GT fracture fragment were chosen according to fracture type. Type A was fixed with figure of 8 wiring using 16-gauge wires, type B was fixed using the combination of figure of 8 wiring and cerclage wiring, and type C and D fractures were fixed with cerclage wiring alone (<xref rid="T1-hp-31-144" ref-type="table">Table 1</xref>). Non-absorbable sutures (ethibond No. 1; Ethicon, Somerville, NJ, USA) were used to further reinforce fixation in comminuted fractures.</p><p>Patients began ambulation using a walking aid (walker) from the 3<sup>rd</sup> postoperative day without a weight-bearing limit. Radiography was carried out before discharge and one month after discharge at one-month intervals to evaluate femoral stem subsidence and the fixation status of the greater trochanteric fragments. Fracture union was defined when fixation was well maintained without wire breakage on follow-up radiographic views. Failure of fixation was defined as a displacement of greater than 5 mm with breakage of the wire used for greater trochanteric fragment fixation. The success rate of fixation according to the fracture type of the GT was compared with the Kruskal&#x2013;Wallis test. Gait ability was assessed using Clawson's Ambulation Capacity Classification<xref rid="B14-hp-31-144" ref-type="bibr">14)</xref> before injury and at the final follow-up.</p><p>This study was approved by the Institutional Review Board of Kwangju Christian Hospital (KCH-2018-03-005). <italic>P</italic>-value of less than 0.05 were considered statistically significant. Statistical analysis was performed using the IBM SPSS ver.19 (IBM Corp., Armonk, NY, USA).</p></sec><sec sec-type="results"><title>RESULTS</title><p>According to the AO/OTA classification, There were 7 (15.9%) type A, 20 (45.5%) type B, 6 (13.6%) type C, and 11 (25.0%) type D fractures. The success rate of fracture fixation was 85.7% (6 out of 7) in type A, 90.0% (18 out of 20) in type B, and 100% for type C (6 out of 6) and type D (11 out of 11). No statistical difference was observed in fixation success rate by fracture type (<italic>P</italic>=0.75). Wire breakage was detected in 4 cases within the first 2&#x2013;3 months after surgery. Of these cases, 3 (6.8%) were defined as fixation failure due to displaced fracture fragments. Fixation failure was observed in type A (1 case) and B (2 cases), but not in type C and D (<xref rid="T2-hp-31-144" ref-type="table">Table 2</xref>). Of these 3 cases, only one case had limping while walking.</p><p>At final follow-up, 17 (38.6%) of 44 cases had fully recovered pre-fracture gait ability. Twenty-seven cases had a decrease in walking ability, by one grade (n=15), 2 grades (n=10), and 3 grades (n=2).</p></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>In bipolar hemiarthroplastys performed for the management of comminuted unstable intertrochanteric fractures, since non-union and displacement of the greater trochanteric fragment attached with the abductor muscles may cause pain, limping and hip dislocation, several studies have suggested using different fixation methods to manage the greater trochanteric fragment<xref rid="B8-hp-31-144" ref-type="bibr">8</xref><xref rid="B9-hp-31-144" ref-type="bibr">9</xref><xref rid="B10-hp-31-144" ref-type="bibr">10</xref><xref rid="B11-hp-31-144" ref-type="bibr">11</xref><xref rid="B12-hp-31-144" ref-type="bibr">12)</xref>. Koyama et al.<xref rid="B15-hp-31-144" ref-type="bibr">15)</xref> proposed a fixation technique using a multifilament cable grip in revision hip arthroplasty after a greater trochanteric osteotomy. A cable grip can provide increased stability in the fixation of relatively large fragments, but has limited application to osteoporotic and severe comminuted fractures and is associated with high costs and postoperative irritations. On the contrary, wire fixation is a simple procedure that can minimize soft tissue injury and seems to be a more suitable method for fixation for different configurations of greater trochanteric fragments from osteoporotic intertrochanteric fractures because the shape of the wires can be customized<xref rid="B8-hp-31-144" ref-type="bibr">8)</xref>. Kim et al.<xref rid="B16-hp-31-144" ref-type="bibr">16)</xref> reported that wiring was an effective method by achieving successful results in 80% of the patients after fixation of the greater trochanteric fragment. Suh et al.<xref rid="B17-hp-31-144" ref-type="bibr">17)</xref> addressed that tension-band wiring was the optimal treatment choice after fixation of fracture fragments using figure-8, cerclage and tension-band wiring. Chin and Brick<xref rid="B18-hp-31-144" ref-type="bibr">18)</xref> and Wang et al.<xref rid="B19-hp-31-144" ref-type="bibr">19)</xref> also recommended that fixation of the GT fracture fragments using wires was a relatively simple and easy procedure that can minimize soft tissue injury compared to cable grip or other reattachment systems. In multifilament cable reattachment systems, cables had to be removed due to irritation. For this reason, we chose 16-gauge wires that can minimize soft tissue injury and be fixed in various methods.</p><p>We reported that the GT fracture fragments vary in shape and can be classified as different types in bipolar hemiarthroplasty used for intertrochanteric fractures of the femur<xref rid="B13-hp-31-144" ref-type="bibr">13)</xref>. Although a previous study identified a difference in radiographic outcomes according to the type of fractures, the study was limited because fixation methods were not selected based on the fracture type. We realized the need for further study to investigate the surgical outcomes of different fixation methods chosen based on the classification of fracture types. Since several muscles are attached to the GT of the femur (e.g., abductors, vastus lateralis, short external rotators), we classified fractures into four types assuming that muscular action by the site and direction of the fracture determines the stability and displacement of the GT fragments. More rigid fixation was needed because the fracture fragment was more displaced upwards by the pull of the adductors in type A and B fractures (<xref ref-type="fig" rid="F2-hp-31-144">Fig. 2</xref>). On the contrary, cerclage wiring seemed to be sufficient to fix type C and D fractures because the force causing an upward displacement was relatively weak by the balanced pulling forces of the abductors proximally and vastus lateralis distally (<xref ref-type="fig" rid="F3-hp-31-144">Fig. 3</xref>). As a result of choosing a fixation method according the type of fractures using our classification system, failure occurred in only 3 out of 44 cases. This outcome demonstrates that, as we expected, the fixation method should be specifically selected based on the type of fracture fragments because of differences in fragment stability depending on the fracture type. No failure of fracture fixation occurred after cerclage wiring in type C and D fractures having relatively greater stability of fracture fragments. Even though the success rate of fixation was not statistically significantly different between type A and B and type C and D fractures, fixation failure occurred in 1 case in type A and 2 in type B (<xref ref-type="fig" rid="F4-hp-31-144">Fig. 4</xref>). We anticipate that better clinical outcomes can be expected if figure-8 wiring is performed using two single filament or multiple filament wires, instead of one single-filament wire. Patients were allowed to ambulate on the 3<sup>rd</sup> postoperative day. Wire breakage occurred at an average of two months after surgery. This was thought to be attributed to the use of a single 16-gauge wire that was unable to endure the pulling force of the abductors. There are some limitations to this study, including all operations being performed by a single surgeon, absence of a control group and the small sample size. Since hip fracture rates are increasing with a rapidly aging population, future studies with larger sample sizes are thought to be warranted to determine the optimal treatment modality for GT fragments.</p></sec><sec sec-type="conclusions"><title>CONCLUSION</title><p>Selecting a fixation method according to GT fracture type can help identify the most appropriate treatment choice.</p></sec></body><back><fn-group><fn fn-type="COI-statement"><p><bold>CONFLICT OF INTEREST:</bold> The authors declare that there is no potential conflict of interest relevant to this article.</p></fn></fn-group><ref-list><ref id="B1-hp-31-144"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dhanwal</surname><given-names>DK</given-names></name><name><surname>Dennison</surname><given-names>EM</given-names></name><name><surname>Harvey</surname><given-names>NC</given-names></name><name><surname>Cooper</surname><given-names>C</given-names></name></person-group><article-title>Epidemiology of hip fracture: Worldwide geographic variation</article-title><source>Indian J Orthop</source><year>2011</year><volume>45</volume><fpage>15</fpage><lpage>22</lpage><pub-id pub-id-type="pmid">21221218</pub-id></element-citation></ref><ref id="B2-hp-31-144"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Broos</surname><given-names>PL</given-names></name><name><surname>Rommens</surname><given-names>PM</given-names></name><name><surname>Geens</surname><given-names>VR</given-names></name><name><surname>Stappaerts</surname><given-names>KH</given-names></name></person-group><article-title>Pertrochanteric fractures in the elderly. 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ununited greater trochanter after revision hip arthroplasty: the abductor slide technique. A review of four cases</article-title><source>J Bone Joint Surg Am</source><year>2000</year><volume>82</volume><fpage>401</fpage><lpage>408</lpage><pub-id pub-id-type="pmid">10724232</pub-id></element-citation></ref><ref id="B19-hp-31-144"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>JW</given-names></name><name><surname>Chen</surname><given-names>LK</given-names></name><name><surname>Chen</surname><given-names>CE</given-names></name></person-group><article-title>Surgical treatment of fractures of the greater trochanter associated with osteolytic lesions</article-title><source>J Bone Joint Surg Am</source><year>2005</year><volume>87</volume><fpage>2724</fpage><lpage>2728</lpage><pub-id pub-id-type="pmid">16322623</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="F1-hp-31-144" orientation="portrait" position="float"><label>Fig. 1</label><caption><title>Greater trochanter (GT) fracture classification. (<bold>A</bold>) Type A is a fracture with transverse direction above the inferior border of the GT. (<bold>B</bold>) Type B is a fracture with oblique direction above the inferior border of the GT. (<bold>C</bold>) Type C is a fracture with transverse direction below the inferior border of the GT. (<bold>D</bold>) Type D is a fracture with oblique direction below the inferior border of the GT.</title></caption><graphic xlink:href="hp-31-144-g001"/></fig><fig id="F2-hp-31-144" orientation="portrait" position="float"><label>Fig. 2</label><caption><title>(<bold>A</bold>) An 88-year-old female with an unstable intertrochanteric fracture of the right femur. Type A greater trochanter (GT) fracture was observed using computer tomography (<bold>B</bold>) and intraoperative findings (<bold>C</bold>). (<bold>D</bold>) The GT fragment was fixed using figure-8 wiring and non-absorbable suture.</title></caption><graphic xlink:href="hp-31-144-g002"/></fig><fig id="F3-hp-31-144" orientation="portrait" position="float"><label>Fig. 3</label><caption><title>(<bold>A</bold>) An 83-year-old female with an unstable intetrochanteric fracture in her left hip. (<bold>B</bold>) Type D greater trochanter (GT) fracture was observed using computer tomography. (<bold>C</bold>) The GT fragment was fixed with cerclage wires.</title></caption><graphic xlink:href="hp-31-144-g003"/></fig><fig id="F4-hp-31-144" orientation="portrait" position="float"><label>Fig. 4</label><caption><title>(<bold>A</bold>) An 85-year-old female with an intertrochanteric fracture with a type B greater trochanter (GT) fracture. (<bold>B</bold>) The GT fracture was fixed using figure-8 wiring. (<bold>C</bold>) At 2 months after operation, the wire was broken and the fragment was also migrated proximally.</title></caption><graphic xlink:href="hp-31-144-g004"/></fig><table-wrap id="T1-hp-31-144" orientation="portrait" position="float"><label>Table 1</label><caption><title>Classification of Greater Trochanter Fractures and Fixation Methods according to Types</title></caption><alternatives><graphic xlink:href="hp-31-144-i001"/><table frame="hsides" rules="rows"><col width="15.22%" span="1"/><col width="36.23%" span="1"/><col width="48.55%" span="1"/><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Type<sup>*</sup></th><th valign="top" align="center" rowspan="1" colspan="1">Case (%)</th><th valign="top" align="center" rowspan="1" colspan="1">Fixation method</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">A</td><td valign="top" align="center" rowspan="1" colspan="1">7 (15.9)</td><td valign="top" align="center" rowspan="1" colspan="1">F8 (n=7)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">B</td><td valign="top" align="center" rowspan="1" colspan="1">20 (45.5)</td><td valign="top" align="center" rowspan="1" colspan="1">F8 only (n=6), F8+CW (n=14)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">C</td><td valign="top" align="center" rowspan="1" colspan="1">6 (13.6)</td><td valign="top" align="center" rowspan="1" colspan="1">CW (n=6)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">D</td><td valign="top" align="center" rowspan="1" colspan="1">11 (25.0)</td><td valign="top" align="center" rowspan="1" colspan="1">CW (n=11)</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>F8: figure of eight wiring, CW: cerclage wiring.</p><p><sup>*</sup>This type was based on the AO/OTA classification.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2-hp-31-144" orientation="portrait" position="float"><label>Table 2</label><caption><title>Radiologic Assessment and Fixation Failure Rate</title></caption><alternatives><graphic xlink:href="hp-31-144-i002"/><table frame="hsides" rules="rows"><col width="22.12%" span="1"/><col width="20.51%" span="1"/><col width="18.91%" span="1"/><col width="12.82%" span="1"/><col width="12.82%" span="1"/><col width="12.82%" span="1"/><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Type<sup>*</sup></th><th valign="top" align="center" rowspan="1" colspan="1">Displacement (&#x2264;3 mm)</th><th valign="top" align="center" rowspan="1" colspan="1">Displacement (&gt;5 mm)</th><th valign="top" align="center" rowspan="1" colspan="1">Wire loosening</th><th valign="top" align="center" rowspan="1" colspan="1">Wire breakage</th><th valign="top" align="center" rowspan="1" colspan="1">Fixation failure (%)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">A (n=7)</td><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1">1</td><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1">1</td><td valign="top" align="center" rowspan="1" colspan="1">1 (14.3)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">B (n=20)</td><td valign="top" align="center" rowspan="1" colspan="1">3</td><td valign="top" align="center" rowspan="1" colspan="1">2</td><td valign="top" align="center" rowspan="1" colspan="1">1</td><td valign="top" align="center" rowspan="1" colspan="1">3</td><td valign="top" align="center" rowspan="1" colspan="1">2 (10.0)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">C (n=6)</td><td valign="top" align="center" rowspan="1" colspan="1">2</td><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1">0 (0)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">D (n=11)</td><td valign="top" align="center" rowspan="1" colspan="1">1</td><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1">0 (0)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Total (n=44)</td><td valign="top" align="center" rowspan="1" colspan="1">6</td><td valign="top" align="center" rowspan="1" colspan="1">3</td><td valign="top" align="center" rowspan="1" colspan="1">1</td><td valign="top" align="center" rowspan="1" colspan="1">4</td><td valign="top" align="center" rowspan="1" colspan="1">3 (6.8)</td></tr></tbody></table></alternatives></table-wrap></floats-group></article>
