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<article article-type="Review Article" dtd-version="1.0" xml:lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">jkfas</journal-id>
<journal-title-group>
<journal-title>Journal of Korean Foot and Ankle Society</journal-title>
<abbrev-journal-title>J Korean Foot Ankle Soc</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">1738-3757</issn>
<issn pub-type="epub">2288-8551</issn>
<publisher>
<publisher-name>Korean Foot and Ankle Society</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.14193/jkfas.2018.22.4.135</article-id>
<article-id pub-id-type="publisher-id">jkfas-22-135</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Evidence-based Treatment of Acute Lateral Ankle Sprain</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Cho</surname><given-names>Byung-Ki</given-names></name>
<xref ref-type="aff" rid="aff1-jkfas-22-135"/>
<xref ref-type="corresp" rid="c1-jkfas-22-135"/>
</contrib>
<aff id="aff1-jkfas-22-135" xml:lang="en">Department of Orthopedic Surgery, Chungbuk National University College of Medicine, Cheongju, <country>Korea</country></aff>
</contrib-group>
<author-notes>
<corresp id="c1-jkfas-22-135">Corresponding Author: Byung-Ki Cho Department of Orthopedic Surgery, Chungbuk National University Hospital, 776 1sunhwan-ro, Seowon-gu, Cheongju 28644, Korea Tel: 82-43-269-6077, Fax: 82-43-274-8719, E-mail: <email>titanick25@naver.com</email> ORCID: https://orcid.org/0000-0001-7746-598X</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>1</month><year>2018</year></pub-date>
<pub-date pub-type="epub"><day>19</day><month>1</month><year>2018</year></pub-date>
<volume>22</volume>
<issue>4</issue>
<fpage>135</fpage>
<lpage>144</lpage>
<history>
<date date-type="received"><day>18</day><month>09</month><year>2018</year></date>
<date date-type="revised"><day>26</day><month>10</month><year>2018</year></date>
<date date-type="accepted"><day>06</day><month>11</month><year>2018</year></date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2018 Korean Foot and Ankle Society</copyright-statement>
<copyright-year>2018</copyright-year>
<license><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0">http://creativecommons.org/licenses/by-nc/4.0</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license>
</permissions>
<abstract xml:lang="en"><p>Acute lateral ankle sprain, which is the most common musculoskeletal injury, can be treated effectively with appropriate evidence-based initial care using PRICE (protection, rest, ice, compression, and elevation) and functional rehabilitation. Many systemic reviews reporting a high-level of evidence supporting the clinical usefulness and necessity of primary surgical repair for acute lateral ankle sprain have been insufficient. Regardless of the severity of ligament complex injuries, the surgical treatment for acute lateral ankle sprain without concomitant pathologies is not recommended and should be considered only in young professional athletes with complete ligament rupture (grade III) and severe instability.</p>
</abstract>
<kwd-group xml:lang="en">
<kwd>Ankle</kwd>
<kwd>Sprain</kwd>
<kwd>Treatment</kwd>
<kwd>Evidence-based</kwd>
</kwd-group>
</article-meta>
</front>
<back>
<ref-list xml:lang="en">
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</ref-list>
<sec sec-type="display-objects">
<title>Figures and Tables</title>
<fig id="f1-jkfas-22-135" position="float">
<label>Figure 1.</label>
<caption xml:lang="en"><p>Photograph of passive range of motion exercise using a band.</p></caption>
<graphic xlink:href="jkfas-22-135f1.tif"/>
</fig>
<fig id="f2-jkfas-22-135" position="float">
<label>Figure 2.</label>
<caption xml:lang="en"><p>Photographs of isometric peroneal strengthening exercise using a ball (A) and Achilles strengthening exercise against a wall (B).</p></caption>
<graphic xlink:href="jkfas-22-135f2.tif"/>
</fig>
<fig id="f3-jkfas-22-135" position="float">
<label>Figure 3.</label>
<caption xml:lang="en"><p>(A, B) Photographs of isotonic peroneal strengthening exercise using a band.</p></caption>
<graphic xlink:href="jkfas-22-135f3.tif"/>
</fig>
<fig id="f4-jkfas-22-135" position="float">
<label>Figure 4.</label>
<caption xml:lang="en"><p>Photograph of single leg balance exercise.</p></caption>
<graphic xlink:href="jkfas-22-135f4.tif"/>
</fig>
<table-wrap id="t1-jkfas-22-135" position="float">
<label>Table 1.</label>
<caption xml:lang="en"><p>Clinical Classification of Lateral Ankle Ligaments Injury<sup>14</sup>)</p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="center">Grade</th>
<th valign="middle" align="center">Injured ligament</th>
<th valign="middle" align="center">Clinical symptoms</th>
<th valign="middle" align="center">Stress test</th>
</tr>
</thead>
<tbody>
<tr>
<td>I</td>
<td>ATFL stretched</td>
<td>Mild swelling and tenderness</td>
<td>Anterior drawer test (&#x2015;)</td>
</tr>
<tr>
<td/>
<td/>
<td>Minimal difficulty with ROM and weightbearing</td>
<td>Varus tilt test (&#x2015;)</td>
</tr>
<tr>
<td>II</td>
<td>ATFL torn and/or CFL tear</td>
<td>Moderate swelling and ecchymosis</td>
<td>Anterior drawer test (+)</td>
</tr>
<tr>
<td/>
<td/>
<td>Anterolateral ankle tenderness</td>
<td>Varus tilt test (&#x2015;)</td>
</tr>
<tr>
<td/>
<td/>
<td>Restricted ROM, increasing difficulty to bear weight</td>
<td/></tr>
<tr>
<td>III</td>
<td>ATFL, CFL torn and/or PTFL tear</td>
<td>Diffuse swelling and ecchymosis</td>
<td>Anterior drawer test (+)</td>
</tr>
<tr>
<td/>
<td/>
<td>Tenderness over anterolateral capsule, ATFL, CFL</td>
<td>Varus tilt test (+)</td>
</tr>
<tr>
<td/>
<td/>
<td>Inability to bear weight</td>
<td/></tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table1-fn1-jkfas-22-135"><p>Data from the article of Jackson et al. (Clin Orthop Relat Res. 1974;101:201-15).<sup>14</sup>) ATFL: anterior talofibular ligament, CFL: calcaneofibular ligament, PTFL: posterior talofibular ligament, ROM: range of motion.</p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="t2-jkfas-22-135" position="float">
<label>Table 2.</label>
<caption xml:lang="en"><p>Classification of Lateral Ankle Ligament Injury and Treatment Recommendations<sup>15)</sup></p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="center">Classification</th>
<th valign="middle" align="center">Criteria</th>
<th valign="middle" align="center">Recommendation</th>
</tr>
</thead>
<tbody>
<tr>
<td>Type I</td>
<td>Stable ankle to clinical testing (with anesthesia, if necessary)</td>
<td>Symptomatic treatment</td>
</tr>
<tr>
<td>Type II</td>
<td>Unstable ankle with positive anterior drawer test or positive talar tilt test or both</td>
<td/></tr>
<tr>
<td>Group 1</td>
<td>Nonathlete or older patient</td>
<td>Functional treatment</td>
</tr>
<tr>
<td>Group 2</td>
<td>Athlete or high-demand patient</td>
<td/></tr>
<tr>
<td>Type A</td>
<td>Negative radiographic stress test</td>
<td>Functional treatment</td>
</tr>
<tr>
<td>Type B</td>
<td>Positive radiographic stress test (talar tilt angle &#x003E;15&#x3002;, anterior talar translation &#x003E;10 mm)</td>
<td>Surgical repair</td>
</tr>
<tr>
<td>Type C</td>
<td>Subtalar instability (+)</td>
<td>Functional treatment</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table2-fn1-jkfas-22-135"><p>Data from the book of Coughlin and Mann (Surgery of the foot and ankle. 7th ed. St. Louis: Mosby; 1999).<sup>15)</sup></p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="t3-jkfas-22-135" position="float">
<label>Table 3.</label>
<caption xml:lang="en"><p>Functional Rehabilitation Program after Acute Lateral Ankle Sprain</p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="center">Goal</th>
<th valign="middle" align="center">Suggested exercises</th>
<th valign="middle" align="center">Frequency and duration</th>
</tr>
</thead>
<tbody>
<tr>
<td>Restoration of motion</td>
<td/>
<td/></tr>
<tr>
<td>Active ROM exercise</td>
<td>Circle exercise or alphabet exercise</td>
<td>10 times at a time</td>
</tr>
<tr>
<td>Passive ROM exercise</td>
<td>Stretching using band or towel (refer to Fig. 1) Stationary bicycle</td>
<td>Repetition (5 times a day)</td>
</tr>
<tr>
<td>Strengthening exercise</td>
<td/>
<td/></tr>
<tr>
<td>Isometric exercise</td>
<td>Push against a wall or fixed object (refer to Fig. 2)</td>
<td>Maintenance for 10 seconds</td>
</tr>
<tr>
<td>Isotonic exercise</td>
<td>Resistive exercise using band (refer to Fig. 3)</td>
<td>10 times at a time</td>
</tr>
<tr>
<td>Plantarflexion</td>
<td/>
<td>Repetition (5 times a day)</td>
</tr>
<tr>
<td>Dorsiflexion</td>
<td/>
<td/></tr>
<tr>
<td>Inversion</td>
<td/>
<td/></tr>
<tr>
<td>Eversion</td>
<td>Peroneal strengthening exercise</td>
<td/></tr>
<tr>
<td>Proprioceptive training</td>
<td>Balance exercise on wobble or tilt board</td>
<td>5 times at a time</td>
</tr>
<tr>
<td/>
<td>One-leg standing with eyes open</td>
<td>Repetition (3 times a day)</td>
</tr>
<tr>
<td/>
<td>One-leg standing with eyes closed (refer to Fig. 4)</td>
<td/></tr>
<tr>
<td/>
<td>Progress from static to dynamic balance</td>
<td/></tr>
<tr>
<td>Walking &#x0026; jogging</td>
<td>Gait training with straight plane</td>
<td>Distance gradually increase</td>
</tr>
<tr>
<td/>
<td>Zigzag walking</td>
<td/></tr>
<tr>
<td/>
<td>Forward and backward jogging</td>
<td/></tr>
<tr>
<td>Running</td>
<td>Figure-8-running</td>
<td>Distance gradually increase</td>
</tr>
<tr>
<td/>
<td>Cutting &#x0026; jumping</td>
<td/></tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table3-fn1-jkfas-22-135"><p>Running Figure-8-running Distance gradually increase Cutting &#x0026; jumping</p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="t4-jkfas-22-135" position="float">
<label>Table 4.</label>
<caption xml:lang="en"><p>Clinical Outcomes after Surgical Treatment for Acute Lateral Ankle Ligament Injury</p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="center">Study</th>
<th valign="middle" align="center">Journal</th>
<th valign="middle" align="center">Key result</th></tr>
</thead>
<tbody>
<tr>
<td>Povacz et al. (1998)<sup>47)</sup></td>
<td><italic>J Bone Joint Surg Am</italic></td>
<td>Nonoperative treatment of an injury of the fibular collateral ligaments of the ankle yields results that are comparable with those of operative repair and is associated with a shorter period of recovery.</td>
</tr>
<tr>
<td>Pijnenburg et al. (2000)<sup>46)</sup></td>
<td><italic>J Bone Joint Surg Am</italic></td>
<td>Operative treatment for ruptures of the lateral ankle ligaments leads to better results than functional treatment, and functional treatment leads to better results than cast immobilization for six weeks.</td>
</tr>
<tr>
<td>Specchiulli and Cofano (2001)<sup>40)</sup></td>
<td><italic>Orthopedics</italic></td>
<td>No significant differences were found between the primary repair and conservative management groups with regard to objective or subjective stability, functional scores, or the overall result.</td>
</tr>
<tr>
<td>Pijnenburg et al. (2003)<sup>45)</sup></td>
<td><italic>J Bone Joint Surg Br</italic></td>
<td>Compared with functional treatment, operative treatment gives a better long-term outcome in terms of residual pain, recurrent sprains and stability.</td>
</tr>
<tr>
<td>Pihlajam&#x00E4;ki et al. (2010)<sup>44)</sup></td>
<td><italic>J Bone Joint Surg Am</italic></td>
<td>The long-term results of surgical treatment of acute lateral ligament rupture of the ankle correspond with those of functional treatment. Although surgery appeared to decrease the prevalence of reinjury of the lateral ligaments, there may be an increased risk for the subsequent development of osteoarthritis.</td>
</tr>
<tr>
<td>Takao et al. (2012)<sup>48)</sup></td>
<td><italic>Am J Sports Med</italic></td>
<td>Functional treatment alone and functional treatment after primary surgical repair showed similar overall results after acute lateral ankle sprain. But, functional treatment alone had an approximately 10% failure rate and a slower return to full athletic activity.</td>
</tr>
<tr>
<td>White et al. (2016)<sup>49)</sup></td>
<td><italic>Knee Surg Sports Traumatol Arthrosc</italic></td>
<td>Acute repair of grade III injuries in professional high-demand athlete leads to a predictable return to sport (approximately 10 weeks) and may reduce the incidence of repeat sprains and intra-articular damage.</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="t5-jkfas-22-135" position="float">
<label>Table 5.</label>
<caption xml:lang="en"><p>Recent Systemic Reviews regarding the Conservative and Surgical Treatments for Acute Lateral Ankle Sprain</p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="center">Study</th>
<th valign="middle" align="center">Conclusion</th>
</tr>
</thead>
<tbody>
<tr>
<td>Kerkhoffs et al. (2007)<sup>3)</sup></td>
<td>There are insufficient high-quality randomized controlled trials available to give a final judgement on the effectiveness of surgery compared with conservative treatment.</td>
</tr>
<tr>
<td>Chan et al. (2011)<sup>16)</sup></td>
<td>Given that the results of secondary repair are similar to primary repair and that functional treatment has yielded similar outcomes, surgery is rarely indicated in the acute setting.</td>
</tr>
<tr>
<td>Kerkhoffs et al. (2012)<sup>23)</sup></td>
<td>There was some limited evidence for longer recovery times, and higher incidences of ankle stiffness, impaired ankle mobility and complications after surgical treatment. Functional treatment is preferred over surgical therapy.</td>
</tr>
<tr>
<td>van den Bekerom et al. (2013)<sup>4)</sup></td>
<td>Successful treatment of grade II and III acute lateral ankle ligament injuries can be achieved with individualized aggressive, nonoperative measures. Acute repair of the lateral ankle ligaments in grade III injuries in professional athletes may give better results.</td>
</tr>
<tr>
<td>Petersen et al. (2013)<sup>22)</sup></td>
<td>The majority of grades I, II, and III lateral ankle ligament ruptures can be managed without surgery. The indication for surgical repair should be always made on an individual basis.</td>
</tr>
<tr>
<td>Chaudhry et al. (2015)<sup>50)</sup></td>
<td>Cochrane review failed to demonstrate a benefit of surgery compared with conservative management for acute lateral ligament complex injuries. Surgery for acute lateral ligament complex injuries is not recommended, regardless of severity.</td>
</tr>
<tr>
<td>Al-Mohrej and Al-Kenani (2016)<sup>24)</sup></td>
<td>Regardless of severity, surgery for acute ankle sprain is not recommended anymore.</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
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</article>