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<article article-type="Original Article" dtd-version="1.0" xml:lang="ko" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">JKOA</journal-id>
<journal-title-group>
<journal-title xml:lang="en">Journal of the Korean Orthopaedic Association</journal-title>
<abbrev-journal-title abbrev-type="publisher" xml:lang="en">J Korean Orthop Assoc</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">1226-2102</issn>
<issn pub-type="epub">2005-8918</issn>
<publisher>
<publisher-name>The Korean Orthopaedic Association</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.4055/jkoa.2019.54.3.281</article-id>
<article-id pub-id-type="publisher-id">jkoa-54-281</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Total Hip Arthroplasty in Patients with Avascular Necrosis of the Entire Femur</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Seung</surname><given-names>Rim Yi</given-names></name><degrees>M.D., Ph.D.</degrees>
<xref ref-type="aff" rid="aff1-jkoa-54-281"/>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Se</surname><given-names>Hyuk Im</given-names></name><degrees>M.D.</degrees>
<xref ref-type="aff" rid="aff1-jkoa-54-281"/>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Sang</surname><given-names>Hoon Park</given-names></name><degrees>M.D.</degrees>
<xref ref-type="aff" rid="aff1-jkoa-54-281"/>
</contrib>
<aff id="aff1-jkoa-54-281" xml:lang="en"><italic>Department of Orthopedic Surgery, National Police Hospital, Seoul, Korea</italic></aff>
</contrib-group>
<author-notes>
<corresp id="c1-jkoa-54-281"><bold>Correspondence to:</bold> Se Hyuk Im, M.D. Department of Orthopedic Surgery, National Police Hospital, 123 Songi-ro, Songpa-gu, Seoul 05715, Korea <bold>TEL:</bold> +82-2-3400-1247 <bold>FAX:</bold> +82-2-4492-2120 <bold>E-mail:</bold> <email>ish0524@hanmail.net</email> <bold>ORCID:</bold> <ext-link ext-link-type="uri" xlink:href="https://orcid.org/0000-0003-3329-7923">https://orcid.org/0000-0003-3329-7923</ext-link></corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>12</month>
<year>2019</year>
</pub-date>
<volume>54</volume>
<issue>3</issue>
<fpage>281</fpage>
<lpage>286</lpage>
<history>
<date date-type="received">
<day>10</day>
<month>05</month>
<year>2018</year>
</date>
<date date-type="revised">
<day>19</day>
<month>07</month>
<year>2018</year>
</date>
<date date-type="accepted">
<day>6</day>
<month>08</month>
<year>2018</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2019 The Korean Orthopaedic Association</copyright-statement>
<copyright-year>2019</copyright-year>
<license><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0">http://creativecommons.org/licenses/by-nc/3.0</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license>
</permissions>
<abstract xml:lang="en">
<p>Avascular necrosis (AVN) is defined as the cellular death of bone and bone marrow components due to the loss of blood supply, and associated with post-traumatic or non-traumatic events. AVN usually involves the epiphysis of a long bone, such as the femoral and humeral heads, which are susceptible to osteonecrosis. Many studies have been conducted but they were restricted to investigations of femoral head avascular necrosis. The presence of osteonecrosis in the proximal femur may impair biological fixation after total hip arthroplasty. We report a 56-year-old male patient with avascular necrosis located not only at the femoral head, but also in the entire femur, including the medullary cavity, who underwent total hip arthroplasty 2 years earlier along with a review of the relevant literature.</p>
</abstract>
<kwd-group xml:lang="en">
<kwd>entire femur</kwd>
<kwd>avascular necrosis</kwd>
<kwd>total hip arthroplasty</kwd>
<kwd>femoral stem</kwd>
</kwd-group>
</article-meta>
</front>
<back>
<ref-list>
<title>References</title>
<ref id="b1-jkoa-54-281"><label>1.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Ficat</surname><given-names>RP</given-names></name><name><surname>Arlet</surname><given-names>J</given-names></name></person-group><source>Isch&#x00E9;mie et necrose osseuses</source><publisher-name>Paris</publisher-name><publisher-loc>Masson</publisher-loc><year>1977</year><fpage>1</fpage><lpage>224</lpage></element-citation></ref>
<ref id="b2-jkoa-54-281"><label>2.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>ARCO</surname><given-names>(Association Reserch Circularion Osseous) committee on terminology and classification</given-names></name></person-group><source>ARCO News.</source><year>1992</year><volume>4</volume><fpage>41</fpage><lpage>6</lpage></element-citation></ref>
<ref id="b3-jkoa-54-281"><label>3.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Sakai</surname><given-names>T</given-names></name><name><surname>Sugano</surname><given-names>N</given-names></name><name><surname>Nishii</surname><given-names>T</given-names></name><name><surname>Haraguchi</surname><given-names>K</given-names></name><name><surname>Yoshikawa</surname><given-names>H</given-names></name><name><surname>Ohzono</surname><given-names>K</given-names></name></person-group><article-title>Bone scintigraphy for osteonecrosis of the knee in patients with non-traumatic osteonecrosis of the femoral head: comparison with magnetic resonance imaging.</article-title><source>Ann Rheum Dis.</source><year>2001</year><volume>60</volume><fpage>14</fpage><lpage>20</lpage></element-citation></ref>
<ref id="b4-jkoa-54-281"><label>4.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Lafforgue</surname><given-names>P</given-names></name></person-group><article-title>Pathophysiology and natural history of avascular necrosis of bone.</article-title><source>Joint Bone Spine.</source><year>2006</year><volume>73</volume><fpage>500</fpage><lpage>7</lpage></element-citation></ref>
<ref id="b5-jkoa-54-281"><label>5.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>YH</given-names></name><name><surname>Kim</surname><given-names>JS</given-names></name></person-group><article-title>Histologic analysis of acetabular and proximal femoral bone in patients with osteonecrosis of the femoral head.</article-title><source>J Bone Joint Surg Am.</source><year>2004</year><volume>86</volume><fpage>2471</fpage><lpage>4</lpage></element-citation></ref>
<ref id="b6-jkoa-54-281"><label>6.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Calder</surname><given-names>JD</given-names></name><name><surname>Pearse</surname><given-names>MF</given-names></name><name><surname>Revell</surname><given-names>PA</given-names></name></person-group><article-title>The extent of osteocyte death in the proximal femur of patients with osteonecrosis of the femoral head.</article-title><source>J Bone Joint Surg Br.</source><year>2001</year><volume>83</volume><fpage>419</fpage><lpage>22</lpage></element-citation></ref>
<ref id="b7-jkoa-54-281"><label>7.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Sinha</surname><given-names>RK</given-names></name><name><surname>Dungy</surname><given-names>DS</given-names></name><name><surname>Yeon</surname><given-names>HB</given-names></name></person-group><article-title>Primary total hip arthroplasty with a proximally porous-coated femoral stem.</article-title><source>J Bone Joint Surg Am.</source><year>2004</year><volume>86</volume><fpage>1254</fpage><lpage>61</lpage></element-citation></ref>
<ref id="b8-jkoa-54-281"><label>8.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Geesink</surname><given-names>RG</given-names></name><name><surname>de</surname><given-names>Groot K</given-names></name><name><surname>Klein</surname><given-names>CP</given-names></name></person-group><article-title>Bonding of bone to apatite-coated implants.</article-title><source>J Bone Joint Surg Br.</source><year>1988</year><volume>70</volume><fpage>17</fpage><lpage>22</lpage></element-citation></ref>
<ref id="b9-jkoa-54-281"><label>9.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Archibeck</surname><given-names>MJ</given-names></name><name><surname>Berger</surname><given-names>RA</given-names></name><name><surname>Jacobs</surname><given-names>JJ</given-names></name></person-group><etal/><article-title>Second-generation cementless total hip arthroplasty.</article-title><source>Eight to eleven-year results. J Bone Joint Surg Am.</source><year>2001</year><volume>83</volume><fpage>1666</fpage><lpage>73</lpage></element-citation></ref>
<ref id="b10-jkoa-54-281"><label>10.</label><element-citation publication-type="journal/book"><person-group person-group-type="author"><name><surname>Rothman</surname><given-names>RH</given-names></name><name><surname>Cohn</surname><given-names>JC</given-names></name></person-group><article-title>Cemented versus cementless total hip arthroplasty.</article-title><source>A critical review. Clin Orthop Relat Res.</source><year>1990</year><volume>254</volume><fpage>153</fpage><lpage>69</lpage></element-citation></ref>
</ref-list>
<sec sec-type="display-objects">
<title>Figures and Tables</title>
<fig id="f1-jkoa-54-281" position="float">
<label>Figure 1.</label>
<caption xml:lang="en"><p>Anterioposterior (A) and frog leg lateral (B) radiographs show collapse of the right femur head and subchondral fracture.</p></caption>
<graphic xlink:href="jkoa-54-281f1.tif"/>
</fig>
<fig id="f2-jkoa-54-281" position="float">
<label>Figure 2.</label>
<caption xml:lang="en"><p>Coronal (A) and axial (B) T2-weighted fat suppression magnetic resonance imaging show extended necrosis extended to the femur diaphysis.</p></caption>
<graphic xlink:href="jkoa-54-281f2.tif"/>
</fig>
<fig id="f3-jkoa-54-281" position="float">
<label>Figure 3.</label>
<caption xml:lang="en"><p>Anterior and posterior view of technetium-99<sup>m</sup> bone scintigraphs showing diffuse uptake in the right femur suggesting entire femur avascular necrosis.</p></caption>
<graphic xlink:href="jkoa-54-281f3.tif"/>
</fig>
<fig id="f4-jkoa-54-281" position="float">
<label>Figure 4.</label>
<caption xml:lang="en"><p>Right femur (A) and knee (B) T2-weighted fat suppression magnetic resonance imaging show avascular necrosis extended to the lateral femoral condyle.</p></caption>
<graphic xlink:href="jkoa-54-281f4.tif"/>
</fig>
<fig id="f5-jkoa-54-281" position="float">
<label>Figure 5.</label>
<caption xml:lang="en"><p>(A) Postoperative anteroposterior and lateral radiographs show press-fitted femoral stem and acetabular component. (B) Four-month follow-up radiographs show calcar resorption and about 6-mm-sized subsidence is observed (white arrow). (C) Twelve-month follow-up radiographs show progress subsidence to approximately 10 mm but no further progression of subsidence is observed in the 18 months (D) and 24 months (E) follow-up radiographs.</p></caption>
<graphic xlink:href="jkoa-54-281f5.tif"/>
</fig>
</sec>
</back>
</article>