<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.1 20151215//EN" "JATS-journalpublishing1.dtd">
<article xml:lang="EN" article-type="research-article">

<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Ann Surg Treat Res</journal-id>
<journal-id journal-id-type="publisher-id">ASTR</journal-id>
<journal-title-group>
<journal-title>Annals of Surgical Treatment and Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">2288-6575</issn>
<issn pub-type="epub">2288-6796</issn>
<publisher>
<publisher-name>The Korean Surgical Society</publisher-name>
</publisher>
</journal-meta>

<article-meta>
<article-id pub-id-type="doi">10.4174/astr.2019.96.5.209</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Implementation of a resident night float system in a surgery department in Korea for 6 months: electronic medical record-based big data analysis and medical staff survey</article-title>
</title-group>

<contrib-group>

<contrib contrib-type="author">
<name>
<surname>Yu</surname>
<given-names>Hyeong Won</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="fn" rid="FN1">*</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Choi</surname>
<given-names>June Young</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="fn" rid="FN1">*</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Park</surname>
<given-names>Young Suk</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Park</surname>
<given-names>Hyung Sub</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Choi</surname>
<given-names>YoungRok</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Ahn</surname>
<given-names>Sang-Hoon</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Kang</surname>
<given-names>Eunyoung</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Oh</surname>
<given-names>Heung-Kwon</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Kim</surname>
<given-names>Eun-Kyu</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Cho</surname>
<given-names>Jai Young</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Kim</surname>
<given-names>Duck-Woo</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Park</surname>
<given-names>Do Joong</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Yoon</surname>
<given-names>Yoo-Seok</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Kang</surname>
<given-names>Sung Bum</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Kim</surname>
<given-names>Hyung-Ho</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>

<contrib contrib-type="author">
<name>
<surname>Han</surname>
<given-names>Ho-Seong</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>

<contrib contrib-type="author" corresp="yes">
<contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-6425-5924</contrib-id>
<name>
<surname>Lee</surname>
<given-names>Taeseung</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>

</contrib-group>

<aff id="A1"><label>1</label>Department of Surgery, Seoul National University Bundang Hospital, Seongnam, <country>Korea</country>.</aff>
<aff id="A2"><label>2</label>Department of Surgery, Seoul National University College of Medicine, Seoul, <country>Korea</country>.</aff>

<author-notes>
<corresp>Corresponding Author: Taeseung Lee. Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam 13620, Korea. Tel: +82-31-787-7092, Fax: +82-31-787-4078, <email>tslee@snubh.org</email></corresp>
<fn id="FN1" fn-type="equal">
 <p><sup>*</sup>Hyeong Won Yu and June Young Choi contributed equally to this study as co-first authors.</p>
</fn>
</author-notes>

<pub-date pub-type="ppub">
<month>05</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>24</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>96</volume>
<issue>5</issue>
<fpage>209</fpage>
<lpage>215</lpage>

<history>
<date date-type="received">
<day>20</day>
<month>09</month>
<year>2018</year>
</date>
<date date-type="rev-recd">
<day>13</day>
<month>12</month>
<year>2018</year>
</date>
<date date-type="accepted">
<day>21</day>
<month>12</month>
<year>2018</year>
</date>
</history>

<permissions>
<copyright-statement>Copyright &#x00A9; 2019, the Korean Surgical Society</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>The Korean Surgical Society</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">
<license-p>Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>

<abstract>
<sec>
<title>Purpose</title>
<p>To evaluate superiority of a night float (NF) system in comparison to a traditional night on-call (NO) system for surgical residents at a single institution in terms of efficacy, safety, and satisfaction.</p>
</sec>
<sec>
<title>Methods</title>
<p>A NF system was implemented from March to September 2017 and big data analysis from electronic medical records was performed for all patients admitted for surgery or contacted from the emergency room (ER). Parameters including vital signs, mortality, and morbidity rates, as well as promptness of response to ER calls, were compared against a comparable period (March to September 2016) during which a NO system was in effect. A survey was also performed for physicians and nurses who had experienced both systems.</p>
</sec>
<sec>
<title>Results</title>
<p>A total of 150,000 clinical data were analyzed. Under the NO and NF systems, a total of 3,900 and 3,726 patients were admitted for surgery. Mortality rates were similar but postoperative bleeding was significantly higher in the NO system (0.5% <italic>vs.</italic> 0.2%, P = 0.031). From the 1,462 and 1,354 patients under the NO and NF systems respectively, that required surgical consultation from the ER, the time to response was significantly shorter in the NF system (54.5 &#x00B1; 70.7 minutes <italic>vs.</italic> 66.8 &#x00B1; 83.8 minutes, P &#x003C; 0.001). Both physicians (90.4%) and nurses (91.4%) agreed that the NF system was more beneficial.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>This is the first report of a NF system using big data analysis in Korea, and potential benefits of this new system were observed in both ward and ER patient management.</p>
</sec>
</abstract>

<kwd-group>
<kwd>Night shift work</kwd>
<kwd>Residency</kwd>
<kwd>General surgery</kwd>
<kwd>Big data</kwd>
<kwd>Electronic health record</kwd>
</kwd-group>

</article-meta>
</front>

<body>

<sec sec-type="intro">
<title>INTRODUCTION</title>
  <p>Resident working hours are closely related to patient safety [<xref ref-type="bibr" rid="B1">1</xref>]. Long working hours and overtime are known to be associated with increased medical errors from residents [<xref ref-type="bibr" rid="B2">2</xref><xref ref-type="bibr" rid="B3">3</xref>]. Following the Libby Zion accident in New York State in 1984, interest in the working environment of residents has increased [<xref ref-type="bibr" rid="B4">4</xref>]. Currently, many countries have exerted limitations in resident working hours by law. In the United States, the Accreditation Council for Graduate Medical Education (ACGME) is leading the improvement in resident working environment [<xref ref-type="bibr" rid="B5">5</xref>]. Europe and Canada have also implemented resident working hour restrictions [<xref ref-type="bibr" rid="B6">6</xref>].</p>
  <p>Until recently, there were no guidelines on working hours for residents in Korea, and many residents worked more than 100 hours a week [<xref ref-type="bibr" rid="B7">7</xref>]. With the adoption of resident regulations in the US and Europe, interest in resident work environment also increased in Korea. The &#x201C;resident special law&#x201D; (resident training environment improvement program) started in 2015 as an autonomous recommendation and became a system that included legal regulations in 2017. According to this system, residents cannot work more than 88 hours a week for an average of four weeks, including educational training time. Residents are also banned from night duties for more than 3 days a week or for more than 36 consecutive hours of work. Various resident work schedules have been introduced by different institutions to comply with these working hour regulations, but many have been found to be impractical, and the best working model has not been agreed or standardized.</p>
  <p>A night float (NF) system involves a separate team of residents that work on night duties only for a certain period of time and then rotate with other residents on day duties. This system is commonly used in other countries to tackle the issue of restricted working hours as well as limited resident numbers, and this system was temporarily adopted by the Department of Surgery at Seoul National University Bundang Hospital. In this study, we evaluate the superiority of this NF system in comparison to the pre-existing traditional night on-call (NO) system in terms of safety and efficacy, and the preference of this system by the associated medical staff. To our knowledge, this is the first report of the NF system experience in Korea.</p>
</sec>

<sec sec-type="methods">
<title>METHODS</title>
<sec>
<title>Patients</title>
  <p>We collected patient data from March to September 2016 for the NO system and from March to September 2017 for the NF system at Seoul National University Bundang Hospital. All patients admitted for surgery and patients contacted for surgical consultation from the emergency room (ER) were included. Approximately 150,000 clinical patient data were obtained from electronic medical records and big data analysis was performed. For ward patients, we investigated several parameters including age, sex, vital signs (systolic and diastolic blood pressures, heart rate, respiratory rate), nonintended transfers to the intensive care unit (ICU), major postoperative complications (postoperative bleeding, anastomosis site leakage, wound evisceration, small bowel injury, postoperative foreign body removal), and mortality rate. For ER patients, age, sex, and the time to response by residents for calls from the ER were collected. The time to response was defined as the time taken from contact to input of either medical orders or contact notes in the electronic medical record. The time taken was divided into 2-hour intervals and analyzed in detail. This retrospective cohort study was approved by the Institutional Review Board of Seoul National University Bundang Hospital (B-1712-441-106) and exempted from the informed consent.</p>
</sec>
<sec>
<title>NO system</title>
  <p>Under the traditional NO system, all residents worked on regular day duties from 7:00 AM to 7:00 PM, and around 30% continued to work on night duty from 7:00 PM to 7:00 AM the next day (<xref ref-type="fig" rid="F1">Fig. 1</xref>). These residents continued to work immediately on the next day for their full day duty without any break (36 hours of continuous work). This was the traditional working system used until 2016.</p>
</sec>
<sec>
<title>NF system</title>
  <p>On March 2017, a new system of NF was introduced in an attempt to systematically match the 88-hour working regulations for residents implemented by the Korean government. Under this system, only 70% of the residents worked on day duty (<xref ref-type="fig" rid="F1">Fig. 1</xref>), while the remaining 30% of residents worked on night duty. Residents on night duty worked for 12 hours at night for 5 days a week (on weekdays only) and for a total of 1 month. Rotations were done on a monthly basis so that no resident would be on night duty for 2 consecutive months. Residents in the NF system had the advantage of shortened working hours per week as well as reduction in continuous working hours.</p>
</sec>
<sec>
<title>Questionnaire</title>
  <p>A survey was performed in June 2018 to physicians (residents and staffs) and nurses who had directly experienced both the NO and NF systems. A questionnaire was distributed in paper form which included questions related to satisfaction and safety/efficacy parameters under both system and were finally asked to choose between both systems if it were to be permanently implemented in the future.</p>
</sec>
<sec>
<title>Statistical analysis</title>
  <p>Continuous variables were expressed as means &#x00B1; standard deviations. Categorical variables were expressed as number and percentage. Both groups were compared in terms of continuous and categorical variables using Student t-test and Pearson chi-square test, respectively. Differences were considered significant at P-values of &#x003C;0.05. All statistical analyses were performed using IBM SPSS Statistics ver. 22.0 (IBM Co., Armonk, NY, USA).</p>
</sec>
</sec>

<sec sec-type="results">
<title>RESULTS</title>
<sec>
<title>Ward patients</title>
  <p>Under the NO and NF systems, a total of 3,900 and 3,726 patients, respectively were admitted to the department of surgery. The mean age of the patients was 54.7 &#x00B1; 17.5 and 55.2 &#x00B1; 17.9 years (P = 0.204), and the male ratio was 47.8% and 49.3%, respectively (P = 0.181). <xref ref-type="table" rid="T1">Table 1</xref> shows the changes in vital signs, transfers to the ICU, morbidity rates, and mortality rates in ward patients under the NO and NF systems. There were no differences in blood pressure change and ICU transfers between the 2 groups. Postoperative bleeding was significantly higher in the NO system compared to the NF system (0.5% <italic>vs.</italic> 0.2%, P = 0.031). Other major complications such as anastomosis site leakage (P = 0.575), wound evisceration (P = 0.283), small bowel injury (P = 0.197), and postoperative foreign body removal (P = 0.306) were not statistically significant between the two systems. There was also no significant difference in the mortality rate between the 2 systems (P = 0.402).</p>
</sec>
<sec>
<title>ER patients</title>
  <p>Under the NO and NF systems, a total of 1,462 and 1,354 patients respectively, visited the ER and were contacted for surgical consultation. The mean age of the patients was 50.8 &#x00B1; 22.1 and 52.8 &#x00B1; 22.1 years (P = 0.016), and the proportion of male patients was 59.2% and 56.4%, respectively (P = 0.141). <xref ref-type="table" rid="T2">Table 2</xref> shows the time required for ER patients to receive surgical attention under the NO and NF systems. The overall time taken was significantly shorter in the NF system (54.5 &#x00B1; 70.7 minutes) than the NO system (66.8 &#x00B1; 83.8 minutes) (P &#x2264; 0.001). This difference was mostly noticed during the night duties, where the time interval was significantly shorter in the NF system (53.1 &#x00B1; 70.5 minutes) compared to the NO system (72.2 &#x00B1; 80.0 minutes) (P &#x003C; 0.001), while during the day duty the time interval was not so different (55.5 &#x00B1; 70.9 minutes <italic>vs.</italic> 62.8 &#x00B1; 86.3, minutes respectively, P = 0.064). <xref ref-type="fig" rid="F2">Fig. 2</xref> shows a visual representation of the time required for surgical care from the initial time of contact for both NO and NF systems. When analyzed on a 2-hour interval basis, it can be visualized that the response by the NF team was significantly faster than the NO team for all time-points at night, as well as the early morning (7 AM) period.</p>
</sec>
<sec>
<title>Questionnaire</title>
  <p>The results of the questionnaire-based medical staff survey are shown in <xref ref-type="fig" rid="F3">Fig. 3</xref>. The physicians' subjective preferences were the NF system (78.6%), NO system (7.1%), or both (14.3%), and the response as to which system was more beneficial to the hospital was the NF system (90.4%), NO system (4.8%), or both (4.8%). The details of the 42 physicians participating in the questionnaire were as follows: 19 residents and 23 board-certified staff. Of the 3 respondents who answered that the NO system would be beneficial, there were 2 residents and one staff. The 2 residents that supported the NO system expressed their concern that the proportion of resident education would decrease if the system was changed. The nurses' subjective preferences were the NF system (85.7%), NO system (5.7%), or both (8.6%), while their opinion in terms of hospital benefit was the NF system (91.4%), NO system (2.9%), both (4.3%) and none (1.4%).</p>
</sec>
</sec>

<sec sec-type="discussion">
<title>DISCUSSION</title>
  <p>The 1984 death of patient Libby Zion in the United States was an incident that led to increased public awareness about the working conditions of residents, and thereafter a law on resident working hours was put into effect [<xref ref-type="bibr" rid="B4">4</xref>]. Studies have reported the association between cumulative fatigue and poor cognitive function [<xref ref-type="bibr" rid="B8">8</xref><xref ref-type="bibr" rid="B9">9</xref>], and sleep deprivation has been found to negatively affect management in emergent situations [<xref ref-type="bibr" rid="B10">10</xref>]. To reflect this, in 2003, the ACGME already set an 80-hour workweek limit for 4 weeks, and the same agency added a 16-hour continuous work restriction in 2011 [<xref ref-type="bibr" rid="B11">11</xref>]. Accordingly, many institutions have introduced a NF system in order to comply with the working hours of residents [<xref ref-type="bibr" rid="B12">12</xref><xref ref-type="bibr" rid="B13">13</xref>].</p>
  <p>In Korea, a 9-year-old child treated with chemotherapy for leukemia in 2010 died from a medical error [<xref ref-type="bibr" rid="B14">14</xref>]. Intravenous vincristine was accidentally injected into the child's spinal canal and died 10 days later. Since then, medical accidents and patient safety have been extensively investigated. During the course of the investigation, similar events in the past were also discovered, leading to an increased interest in patient safety [<xref ref-type="bibr" rid="B15">15</xref>]. Subsequently, the so-called &#x2018;Jonghyun law&#x2019; for patient safety came into force in 2016. In addition, resident working time restrictions were also discussed, and from 2017 onwards, residents in Korea are not allowed by law to work for more than 88 hours a week, including educational training hours. Our institution discussed the introduction of a NF system with the aim of changing the work schedule of residents in a systematic way. Until 2017, there had been no reports of any surgical department having implemented a NF system in Korea, and therefore a NF system was designed and temporarily implemented.</p>
  <p>Under a traditional NO system, our surgical residents worked an average of more than 100 hours per week. However, with the introduction of the NF system in 2017, the average working time was maintained at 70&#x2013;80 hours per week. A reduction in working hours has been shown to not only improve quality of life [<xref ref-type="bibr" rid="B16">16</xref>], but also allows more time for studying and publishing research papers [<xref ref-type="bibr" rid="B17">17</xref>], as well as more time to spend with their families [<xref ref-type="bibr" rid="B18">18</xref>]. Regarding concerns related to resident training quality, reports have shown that the number of surgical cases experienced by surgical residents has not changed after implementation of working hour restrictions [<xref ref-type="bibr" rid="B19">19</xref>]. The NF system seems to have a positive effect on interns who desire general surgery residents. In fact, preliminary volunteers who wanted to become general surgery residents have decreased by a third since the NF system was discontinued.</p>
  <p>Our analysis of patients admitted to the ward in the NO and NF systems have shown no difference in mortality. In addition, morbidity was significantly reduced in terms of postoperative bleeding. This is similar to a previous study in which working restrictions did not affect the morbidity or mortality of severely-ill patients [<xref ref-type="bibr" rid="B20">20</xref>]. Additionally, it has been reported that introduction of a NF system does not increase medical errors [<xref ref-type="bibr" rid="B21">21</xref>]. Analysis of patients visiting the emergency room showed that the response time was similar during the day time, but under the NF system response was much faster at night, leading to more rapid decision making and treatment. Under the NO system, residents are exposed to sleep deprivation, which has been shown to affect cognitive function [<xref ref-type="bibr" rid="B22">22</xref>], but residents working on night duties in the NF system are much more alert and in better physical and mental conditions. We have observed that the response time is shortest during the dawn, when there is little activity in the wards, and response to ER calls can be done more rapidly. This can only be achieved under a NF system, since all residents are awake and alert.</p>
  <p>In our medical staff survey, both physicians and nurses preferred the NF system, showing a positive perception about the NF system. Residents were satisfied with the NF system since it relates to an increase in their quality of life [<xref ref-type="bibr" rid="B23">23</xref>], while other physicians (nonresidents) and nurses were satisfied with the NF system since it improves resident performance, leading to improvement in their working conditions [<xref ref-type="bibr" rid="B24">24</xref>]. Our medical staff also replied that the NF system is benefical for the hospital, since improved resident performance at all times is probably related to better patient management in the wards and the ER. Response to notifications by nurses was more effective under the NF system, leading to rapid action, and there were no concerns regarding confusion during the process of notifications due to a newly implemented system. Two of our residents did express concerns that a change to the NF system might reduce the quality of their education. Further in-depth studies are required to evaluate this, but the quality of education for residents is one of the priorities of their training program and continuous efforts should be made to efficiently improve resident education in a qualitative way.</p>
  <p>Despite the positive effects of a NF system in achieving the goal of maintaining resident working hours below 88 hours per week, with improvement in resident performance and probably improved patient safety, we have not been able to implement this system permanently due to legislative issues regarding resident training. The current interpretation of the law does not consider night duty work as resident training and therefore under a NF system, residents may not be able to match their training requirements for board certification. However, the resident working hour restrictions in Korea is currently in effect, and many institutions are having difficulties in achieving this goal. Fellows and junior staffs are compensating by working more hours, but this leads to another population at risk of burnout, and the consequences can be more devastating especially in surgical patients where optimal surgical performance is mostly required by this new at-risk population. Therefore this issue should be approached systematically, and we consider that a NF system is a good way to tackle the problem. More prospective studies may be needed, but our experience has shown a clear benefit of a NF system and we hope that our experience will serve as a good example for legislative modifications and implementation by different institutions in the near future.</p>
  <p>In conclusion, our temporary experience of a NF system has shown that resident working hour restrictions can be matched systematically without compromising patient safety. On the contrary, the NF system showed beneficial outcomes in terms of reduced postoperative bleeding for ward patients and faster response to patients in the emergency room leading to prompt management. Associated medical staff were also more satisfied with the NF system and considered this system to be beneficial overall for the hospital.</p>
</sec>

</body>

<back>

<fn-group>
<fn fn-type="conflict">
<label>CONFLICTS OF INTEREST</label>
  <p>No potential conflict of interest relevant to this article was reported.</p>
</fn>

</fn-group>

<ref-list>

  <ref id="B1">
    <label>1</label>
    <element-citation publication-type="book">
      <person-group person-group-type="author">
        <name>
          <surname>Johns</surname>
          <given-names>MM</given-names>
        </name>
        <name>
          <surname>Ulmer</surname>
          <given-names>C</given-names>
        </name>
        <name>
          <surname>Wolman</surname>
          <given-names>DM</given-names>
        </name>
      </person-group>
      <source>Resident duty hours: enhancing sleep, supervision, and safety</source>
      <publisher-loc>Washington (DC)</publisher-loc>
      <publisher-name>National Academies Press (US)</publisher-name>
      <year>2009</year>
    </element-citation>
  </ref>

  <ref id="B2">
    <label>2</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Landrigan</surname>
          <given-names>CP</given-names>
        </name>
        <name>
          <surname>Rothschild</surname>
          <given-names>JM</given-names>
        </name>
        <name>
          <surname>Cronin</surname>
          <given-names>JW</given-names>
        </name>
        <name>
          <surname>Kaushal</surname>
          <given-names>R</given-names>
        </name>
        <name>
          <surname>Burdick</surname>
          <given-names>E</given-names>
        </name>
        <name>
          <surname>Katz</surname>
          <given-names>JT</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>Effect of reducing interns' work hours on serious medical errors in intensive care units</article-title>
      <source>N Engl J Med</source>
      <year>2004</year>
      <volume>351</volume>
      <fpage>1838</fpage>
      <lpage>1848</lpage>
    </element-citation>
  </ref>

  <ref id="B3">
    <label>3</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Jagsi</surname>
          <given-names>R</given-names>
        </name>
        <name>
          <surname>Kitch</surname>
          <given-names>BT</given-names>
        </name>
        <name>
          <surname>Weinstein</surname>
          <given-names>DF</given-names>
        </name>
        <name>
          <surname>Campbell</surname>
          <given-names>EG</given-names>
        </name>
        <name>
          <surname>Hutter</surname>
          <given-names>M</given-names>
        </name>
        <name>
          <surname>Weissman</surname>
          <given-names>JS</given-names>
        </name>
      </person-group>
      <article-title>Residents report on adverse events and their causes</article-title>
      <source>Arch Intern Med</source>
      <year>2005</year>
      <volume>165</volume>
      <fpage>2607</fpage>
      <lpage>2613</lpage>
    </element-citation>
  </ref>

  <ref id="B4">
    <label>4</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Leape</surname>
          <given-names>LL</given-names>
        </name>
      </person-group>
      <article-title>The girl who died twice: every patient's nightmare: the libby zion case and the hidden hazards of hospitals</article-title>
      <source>JAMA</source>
      <year>1996</year>
      <volume>275</volume>
      <fpage>1031</fpage>
    </element-citation>
  </ref>

  <ref id="B5">
    <label>5</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Pastores</surname>
          <given-names>SM</given-names>
        </name>
        <name>
          <surname>O'Connor</surname>
          <given-names>MF</given-names>
        </name>
        <name>
          <surname>Kleinpell</surname>
          <given-names>RM</given-names>
        </name>
        <name>
          <surname>Napolitano</surname>
          <given-names>L</given-names>
        </name>
        <name>
          <surname>Ward</surname>
          <given-names>N</given-names>
        </name>
        <name>
          <surname>Bailey</surname>
          <given-names>H</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>The Accreditation Council for Graduate Medical Education resident duty hour new standards: history, changes, and impact on staffing of intensive care units</article-title>
      <source>Crit Care Med</source>
      <year>2011</year>
      <volume>39</volume>
      <fpage>2540</fpage>
      <lpage>2549</lpage>
    </element-citation>
  </ref>

  <ref id="B6">
    <label>6</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Trontell</surname>
          <given-names>MC</given-names>
        </name>
        <name>
          <surname>Carson</surname>
          <given-names>JL</given-names>
        </name>
        <name>
          <surname>Taragin</surname>
          <given-names>MI</given-names>
        </name>
        <name>
          <surname>Duff</surname>
          <given-names>A</given-names>
        </name>
      </person-group>
      <article-title>The impact of the night float system on internal medicine residency programs</article-title>
      <source>J Gen Intern Med</source>
      <year>1991</year>
      <volume>6</volume>
      <fpage>445</fpage>
      <lpage>449</lpage>
    </element-citation>
  </ref>

  <ref id="B7">
    <label>7</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Oh</surname>
          <given-names>SH</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>JS</given-names>
        </name>
        <name>
          <surname>Lee</surname>
          <given-names>PS</given-names>
        </name>
      </person-group>
      <article-title>A survey on training and working conditions of residents in 2015</article-title>
      <source>J Korean Med Assoc</source>
      <year>2015</year>
      <volume>58</volume>
      <fpage>1179</fpage>
      <lpage>1189</lpage>
    </element-citation>
  </ref>

  <ref id="B8">
    <label>8</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Arnedt</surname>
          <given-names>JT</given-names>
        </name>
        <name>
          <surname>Owens</surname>
          <given-names>J</given-names>
        </name>
        <name>
          <surname>Crouch</surname>
          <given-names>M</given-names>
        </name>
        <name>
          <surname>Stahl</surname>
          <given-names>J</given-names>
        </name>
        <name>
          <surname>Carskadon</surname>
          <given-names>MA</given-names>
        </name>
      </person-group>
      <article-title>Neurobehavioral performance of residents after heavy night call vs after alcohol ingestion</article-title>
      <source>JAMA</source>
      <year>2005</year>
      <volume>294</volume>
      <fpage>1025</fpage>
      <lpage>1033</lpage>
    </element-citation>
  </ref>

  <ref id="B9">
    <label>9</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Jacques</surname>
          <given-names>CH</given-names>
        </name>
        <name>
          <surname>Lynch</surname>
          <given-names>JC</given-names>
        </name>
        <name>
          <surname>Samkoff</surname>
          <given-names>JS</given-names>
        </name>
      </person-group>
      <article-title>The effects of sleep loss on cognitive performance of resident physicians</article-title>
      <source>J Fam Pract</source>
      <year>1990</year>
      <volume>30</volume>
      <fpage>223</fpage>
      <lpage>229</lpage>
    </element-citation>
  </ref>

  <ref id="B10">
    <label>10</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Arzalier-Daret</surname>
          <given-names>S</given-names>
        </name>
        <name>
          <surname>Buleon</surname>
          <given-names>C</given-names>
        </name>
        <name>
          <surname>Bocca</surname>
          <given-names>ML</given-names>
        </name>
        <name>
          <surname>Denise</surname>
          <given-names>P</given-names>
        </name>
        <name>
          <surname>Gerard</surname>
          <given-names>JL</given-names>
        </name>
        <name>
          <surname>Hanouz</surname>
          <given-names>JL</given-names>
        </name>
      </person-group>
      <article-title>Effect of sleep deprivation after a night shift duty on simulated crisis management by residents in anaesthesia. A randomised crossover study</article-title>
      <source>Anaesth Crit Care Pain Med</source>
      <year>2018</year>
      <volume>37</volume>
      <fpage>161</fpage>
      <lpage>166</lpage>
    </element-citation>
  </ref>

  <ref id="B11">
    <label>11</label>
    <element-citation publication-type="webpage">
      <collab>Resident duty hours in the learning and working environment</collab>
      <source>Comparison of 2003 and 2011 standards [Internet]</source>
      <publisher-loc>Chicago (IL)</publisher-loc>
      <publisher-name>Accreditation Council for Graduate Medical Education</publisher-name>
      <year>2000&#x2013;2019</year>
      <date-in-citation content-type="access-date">cited 2014 Jul 18</date-in-citation>
      <comment>Available from: <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.acgme.org/Portals/0/PDFs/dh-ComparisonTable2003v2011.pdf">http://www.acgme.org/Portals/0/PDFs/dh-ComparisonTable2003v2011.pdf</ext-link></comment>
    </element-citation>
  </ref>

  <ref id="B12">
    <label>12</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Ahmed</surname>
          <given-names>N</given-names>
        </name>
        <name>
          <surname>Devitt</surname>
          <given-names>KS</given-names>
        </name>
        <name>
          <surname>Keshet</surname>
          <given-names>I</given-names>
        </name>
        <name>
          <surname>Spicer</surname>
          <given-names>J</given-names>
        </name>
        <name>
          <surname>Imrie</surname>
          <given-names>K</given-names>
        </name>
        <name>
          <surname>Feldman</surname>
          <given-names>L</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>A systematic review of the effects of resident duty hour restrictions in surgery: impact on resident wellness, training, and patient outcomes</article-title>
      <source>Ann Surg</source>
      <year>2014</year>
      <volume>259</volume>
      <fpage>1041</fpage>
      <lpage>1053</lpage>
    </element-citation>
  </ref>

  <ref id="B13">
    <label>13</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Sterling</surname>
          <given-names>L</given-names>
        </name>
        <name>
          <surname>McCaffrey</surname>
          <given-names>C</given-names>
        </name>
        <name>
          <surname>Secter</surname>
          <given-names>M</given-names>
        </name>
        <name>
          <surname>Rich</surname>
          <given-names>R</given-names>
        </name>
        <name>
          <surname>Green</surname>
          <given-names>J</given-names>
        </name>
        <name>
          <surname>Shirreff</surname>
          <given-names>L</given-names>
        </name>
        <etal/>
      </person-group>
      <article-title>Development of a night float call model for obstetrics and gynaecology residency: the process and residents' perceptions</article-title>
      <source>J Obstet Gynaecol Can</source>
      <year>2016</year>
      <volume>38</volume>
      <fpage>1061</fpage>
      <lpage>1064</lpage>
    </element-citation>
  </ref>
  <ref id="B14">
    <label>14</label>
    <element-citation publication-type="webpage">
      <person-group person-group-type="author">
        <name>
          <surname>Jo</surname>
          <given-names>JH</given-names>
        </name>
      </person-group>
      <source>Will sudden death of 9 years old boy lead to a new law for patient safety? OhmyNews [Internet]</source>
      <year>2013</year>
      <month>04</month>
      <day>08</day>
      <date-in-citation content-type="access-date">cited 2018 Sep 12</date-in-citation>
      <comment>Available from: <ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://m.ohmynews.com/NWS_Web/Mobile/at_pg.aspx?CNTN_CD=A0001852173#cb.4081">http://m.ohmynews.com/NWS_Web/Mobile/at_pg.aspx?CNTN_CD=A0001852173#cb.4081</ext-link></comment>
    </element-citation>
  </ref>

  <ref id="B15">
    <label>15</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Kwack</surname>
          <given-names>EK</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>DJ</given-names>
        </name>
        <name>
          <surname>Park</surname>
          <given-names>TI</given-names>
        </name>
        <name>
          <surname>Cho</surname>
          <given-names>KR</given-names>
        </name>
        <name>
          <surname>Kwon</surname>
          <given-names>IH</given-names>
        </name>
        <name>
          <surname>Sohn</surname>
          <given-names>YK</given-names>
        </name>
      </person-group>
      <article-title>Neural toxicity induced by accidental intrathecal vincristine administration</article-title>
      <source>J Korean Med Sci</source>
      <year>1999</year>
      <volume>14</volume>
      <fpage>688</fpage>
      <lpage>692</lpage>
    </element-citation>
  </ref>

  <ref id="B16">
    <label>16</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Mann</surname>
          <given-names>SM</given-names>
        </name>
        <name>
          <surname>Borschneck</surname>
          <given-names>DP</given-names>
        </name>
        <name>
          <surname>Harrison</surname>
          <given-names>MM</given-names>
        </name>
      </person-group>
      <article-title>Implementation of a novel night float call system: resident satisfaction and quality of life</article-title>
      <source>Can J Surg</source>
      <year>2014</year>
      <volume>57</volume>
      <fpage>15</fpage>
      <lpage>20</lpage>
    </element-citation>
  </ref>

  <ref id="B17">
    <label>17</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Namdari</surname>
          <given-names>S</given-names>
        </name>
        <name>
          <surname>Baldwin</surname>
          <given-names>KD</given-names>
        </name>
        <name>
          <surname>Weinraub</surname>
          <given-names>B</given-names>
        </name>
        <name>
          <surname>Mehta</surname>
          <given-names>S</given-names>
        </name>
      </person-group>
      <article-title>Changes in the number of resident publications after inception of the 80-hour work week</article-title>
      <source>Clin Orthop Relat Res</source>
      <year>2010</year>
      <volume>468</volume>
      <fpage>2278</fpage>
      <lpage>2283</lpage>
    </element-citation>
  </ref>

  <ref id="B18">
    <label>18</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Jones</surname>
          <given-names>AM</given-names>
        </name>
        <name>
          <surname>Jones</surname>
          <given-names>KB</given-names>
        </name>
      </person-group>
      <article-title>The 88-hour family: effects of the 80-hour work week on marriage and childbirth in a surgical residency</article-title>
      <source>Iowa Orthop J</source>
      <year>2007</year>
      <volume>27</volume>
      <fpage>128</fpage>
      <lpage>133</lpage>
    </element-citation>
  </ref>

  <ref id="B19">
    <label>19</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Ferguson</surname>
          <given-names>CM</given-names>
        </name>
        <name>
          <surname>Kellogg</surname>
          <given-names>KC</given-names>
        </name>
        <name>
          <surname>Hutter</surname>
          <given-names>MM</given-names>
        </name>
        <name>
          <surname>Warshaw</surname>
          <given-names>AL</given-names>
        </name>
      </person-group>
      <article-title>Effect of work-hour reforms on operative case volume of surgical residents</article-title>
      <source>Curr Surg</source>
      <year>2005</year>
      <volume>62</volume>
      <fpage>535</fpage>
      <lpage>538</lpage>
    </element-citation>
  </ref>

  <ref id="B20">
    <label>20</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Brasel</surname>
          <given-names>KJ</given-names>
        </name>
        <name>
          <surname>Fata</surname>
          <given-names>P</given-names>
        </name>
        <name>
          <surname>Flynn</surname>
          <given-names>TC</given-names>
        </name>
      </person-group>
      <collab>Members of the Evidence Based Reviews in Surgery Group</collab>
      <article-title>Impact of the 80-hour resident work week on mortality and morbidity in trauma patients</article-title>
      <source>Can J Surg</source>
      <year>2013</year>
      <volume>56</volume>
      <fpage>204</fpage>
      <lpage>206</lpage>
    </element-citation>
  </ref>

  <ref id="B21">
    <label>21</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Anderson</surname>
          <given-names>JE</given-names>
        </name>
        <name>
          <surname>Goodman</surname>
          <given-names>LF</given-names>
        </name>
        <name>
          <surname>Jensen</surname>
          <given-names>GW</given-names>
        </name>
        <name>
          <surname>Salcedo</surname>
          <given-names>ES</given-names>
        </name>
        <name>
          <surname>Galante</surname>
          <given-names>JM</given-names>
        </name>
      </person-group>
      <article-title>Restrictions on surgical resident shift length does not impact type of medical errors</article-title>
      <source>J Surg Res</source>
      <year>2017</year>
      <volume>212</volume>
      <fpage>8</fpage>
      <lpage>14</lpage>
    </element-citation>
  </ref>

  <ref id="B22">
    <label>22</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Kim</surname>
          <given-names>HJ</given-names>
        </name>
        <name>
          <surname>Kim</surname>
          <given-names>JH</given-names>
        </name>
        <name>
          <surname>Park</surname>
          <given-names>KD</given-names>
        </name>
        <name>
          <surname>Choi</surname>
          <given-names>KG</given-names>
        </name>
        <name>
          <surname>Lee</surname>
          <given-names>HW</given-names>
        </name>
      </person-group>
      <article-title>A survey of sleep deprivation patterns and their effects on cognitive functions of residents and interns in Korea</article-title>
      <source>Sleep Med</source>
      <year>2011</year>
      <volume>12</volume>
      <fpage>390</fpage>
      <lpage>396</lpage>
    </element-citation>
  </ref>

  <ref id="B23">
    <label>23</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Shirreff</surname>
          <given-names>L</given-names>
        </name>
        <name>
          <surname>Shapiro</surname>
          <given-names>JL</given-names>
        </name>
        <name>
          <surname>Yudin</surname>
          <given-names>MH</given-names>
        </name>
      </person-group>
      <article-title>Perceptions of a night float system of resident call within an obstetrics and gynaecology residency training program</article-title>
      <source>J Obstet Gynaecol Can</source>
      <year>2014</year>
      <volume>36</volume>
      <fpage>957</fpage>
      <lpage>961</lpage>
    </element-citation>
  </ref>

  <ref id="B24">
    <label>24</label>
    <element-citation publication-type="journal">
      <person-group person-group-type="author">
        <name>
          <surname>Goitein</surname>
          <given-names>L</given-names>
        </name>
        <name>
          <surname>Shanafelt</surname>
          <given-names>TD</given-names>
        </name>
        <name>
          <surname>Nathens</surname>
          <given-names>AB</given-names>
        </name>
        <name>
          <surname>Curtis</surname>
          <given-names>JR</given-names>
        </name>
      </person-group>
      <article-title>Effects of resident work hour limitations on faculty professional lives</article-title>
      <source>J Gen Intern Med</source>
      <year>2008</year>
      <volume>23</volume>
      <fpage>1077</fpage>
      <lpage>1083</lpage>
    </element-citation>
  </ref>

</ref-list>

</back>

<floats-group>

<fig position="float" id="F1">
<label>Fig. 1</label>
<caption>
  <title>Conceptual graphic of night on-call (NO) system and night float (NF) system. In the NO system, all residents performed a day duty and about 30% of the residents additionally performed a night duty. The residents worked the next day immediately without a break time after the night duty. On the other hand, in the NF system 70% of residents work on day duty and the remaining 30% of residents work on night duty.</title>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="astr-96-209-g001"></graphic>
</fig>

<fig position="float" id="F2">
<label>Fig. 2</label>
<caption>
  <title>Comparison of the time spent in the emergency room for surgical management in the night on-call (NO) system and the night float (NF) system (minutes). The time spent was shorter in the NF system (54.5 &#x00B1; 70.7 minutes) than the NO system (66.8 &#x00B1; 83.8 minutes) (P &#x2264; 0.001).</title>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="astr-96-209-g002"></graphic>
</fig>

<fig position="float" id="F3">
<label>Fig. 3</label>
<caption>
  <title>Survey results of the night on-call (NO) system and the night float (NF) system from medical staff (physicians and nurses). Physicians and nurses were asked questions both systems in terms of personal preference and hospital benefits. The questionnaire included 23 questions and staff were asked to choose between the NO system, the NF system, both, or none.</title>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="astr-96-209-g003"></graphic>
</fig>

<table-wrap position="float" id="T1">
<label>Table 1</label>
<caption>
  <title>Vital sign change, transfer to intensive care unit, morbidity, and mortality rates in ward patients under the night on-call and night float system</title>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="astr-96-209-i001"></graphic>
<table-wrap-foot>
<fn>
  <p>Values are presented as mean &#x00B1; standard deviation or number (%).</p>
  <p>SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate.</p>
  <p><sup>*</sup>P &#x003C; 0.05, significant difference.</p>
</fn>
</table-wrap-foot>
</table-wrap>

<table-wrap position="float" id="T2">
<label>Table 2</label>
<caption>
  <title>Comparison of the time required for surgery department care in patients visiting the emergency room under the night on-call and night float system</title>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="astr-96-209-i002"></graphic>
<table-wrap-foot>
<fn>
  <p>Values are presented as mean &#x00B1; standard deviation (number of cases) unless otherwise indicated.</p>
  <p><sup>*</sup>P &#x003C; 0.05, significant difference.</p>
</fn>
</table-wrap-foot>
</table-wrap>

</floats-group>

</article>