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<article article-type="Original Article" dtd-version="1.0" xml:lang="ko" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">pmp</journal-id>
<journal-title-group>
<journal-title>Progress in Medical Physics</journal-title>
<abbrev-journal-title>Progress in Medical Physics</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">2508-4445</issn>
<issn pub-type="epub">2508-4453</issn>
<publisher>
<publisher-name>Korean Society of Medical Physics</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.14316/pmp.2019.30.1.1</article-id>
<article-id pub-id-type="publisher-id">pmp-30-1</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Skin Dose Comparison of CyberKnife and Helical Tomotherapy for Head-and-Neck Stereotactic Body Radiotherapy</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Yoon</surname><given-names>Jeongmin</given-names></name>
<xref ref-type="aff" rid="aff1-pmp-30-1"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Park</surname><given-names>Kwangwoo</given-names></name>
<xref ref-type="aff" rid="aff2-pmp-30-1"><sup>2</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Kim</surname><given-names>Jin Sung</given-names></name>
<xref ref-type="aff" rid="aff2-pmp-30-1"><sup>2</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Kim</surname><given-names>Yong Bae</given-names></name>
<xref ref-type="aff" rid="aff2-pmp-30-1"><sup>2</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Lee</surname><given-names>Ho</given-names></name>
<xref ref-type="aff" rid="aff3-pmp-30-1"><sup>3</sup></xref>
<xref ref-type="corresp" rid="c1-pmp-30-1"/>
</contrib>
<aff id="aff1-pmp-30-1"><label>1</label>Department of Radiation Oncology, Seoul National University Hospital</aff>
<aff id="aff2-pmp-30-1"><label>2</label>Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine</aff>
<aff id="aff3-pmp-30-1"><label>3</label>Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, <country>Korea</country></aff>
</contrib-group>
<author-notes>
<corresp id="c1-pmp-30-1"><bold>Corresponding author</bold> Ho Lee (<email>holee@yuhs.ac</email>) Tel: 82-2-2228-4363 Fax: 82-2-2227-7823</corresp></author-notes>
<pub-date pub-type="ppub"><month>03</month><year>2019</year></pub-date>
<pub-date pub-type="epub"><day>19</day><month>03</month><year>2019</year></pub-date>
<volume>30</volume><issue>1</issue><fpage>1</fpage>
<lpage>6</lpage>
<history>
<date date-type="received"><day>03</day><month>12</month><year>2018</year></date>
<date date-type="rev-recd"><day>30</day><month>12</month><year>2018</year></date>
<date date-type="accepted"><day>07</day><month>01</month><year>2019</year></date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2019 Korean Society of Medical Physics</copyright-statement>
<copyright-year>2019</copyright-year>
<license><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0">http://creativecommons.org/licenses/by-nc/3.0</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license>
</permissions>
<abstract xml:lang="en">
<sec>
<title>Purpose:</title>
<p>This study conducts a comparative evaluation of the skin dose in CyberKnife (CK) and Helical Tomotherapy (HT) to predict the accurate dose of radiation and minimize skin burns in head-and-neck stereotactic body radiotherapy.</p>
</sec>
<sec>
<title>Materials and Methods:</title>
<p>Arbitrarily-defined planning target volume (PTV) close to the skin was drawn on the planning computed tomography acquired from a head-and-neck phantom with 19 optically stimulated luminescent dosimeters (OSLDs) attached to the surface (3 OSLDs were positioned at the skin close to PTV and 16 OSLDs were near sideburns and forehead, away from PTV). The calculation doses were obtained from the MultiPlan 5.1.2 treatment planning system using raytracing (RT), finite size pencil beam (FSPB), and Monte Carlo (MC) algorithms for CK. For HT, the skin dose was estimated via convolution superposition (CS) algorithm from the Tomotherapy planning station 5.0.2.5. The prescribed dose was 8 Gy for 95% coverage of the PTV.</p>
</sec>
<sec>
<title>Results and Conclusions:</title>
<p>The mean differences between calculation and measurement values were &#x2212;1.2&#x00B1;3.1%, 2.5&#x00B1;7.9%, &#x2212;2.8&#x00B1;3.8%, &#x2212;6.6&#x00B1;8.8%, and &#x2212;1.4&#x00B1;1.8% in CS, RT, RT with contour correction (CC), FSPB, and MC, respectively. FSPB showed a dose error comparable to RT. CS and RT with CC led to a small error as compared to FSPB and RT. Considering OSLDs close to PTV, MC minimized the uncertainty of skin dose as compared to other algorithms.</p>
</sec>
</abstract>
<kwd-group xml:lang="en">
<kwd>CyberKnife</kwd>
<kwd>Skin dose</kwd>
<kwd>Helical TomoTherapy</kwd>
<kwd>SBRT</kwd>
</kwd-group>
</article-meta>
</front>
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<sec sec-type="display-objects">
<title>Figures and Tables</title>
<fig id="f1-pmp-30-1" position="float">
<label>Fig. 1</label>
<caption xml:lang="en"><p>Nineteen OSLDs attached on the surface of a head-and-neck phantom.</p></caption>
<graphic xlink:href="pmp-30-1f1.tif"/>
</fig>
<fig id="f2-pmp-30-1" position="float">
<label>Fig. 2</label>
<caption xml:lang="en"><p>Comparison of the dose difference between calculated and measured values in 19 OSLDs using RT with and without CC.</p></caption>
<graphic xlink:href="pmp-30-1f2.tif"/>
</fig>
<fig id="f3-pmp-30-1" position="float">
<label>Fig. 3</label>
<caption xml:lang="en"><p>Comparison of the dose difference between calculated and measured values in 19 OSLDs using CS and RT with CC.</p></caption>
<graphic xlink:href="pmp-30-1f3.tif"/>
</fig>
<fig id="f4-pmp-30-1" position="float">
<label>Fig. 4</label>
<caption xml:lang="en"><p>Comparison of the dose difference between calculated and measured values in 19 OSLDs using MC and CS.</p></caption>
<graphic xlink:href="pmp-30-1f4.tif"/>
</fig>
<fig id="f5-pmp-30-1" position="float">
<label>Fig. 5</label>
<caption xml:lang="en"><p>Comparison of the dose difference between calculated and measured values in 19 OSLDs using FSPB and RT.</p></caption>
<graphic xlink:href="pmp-30-1f5.tif"/>
</fig>
<table-wrap id="t1-pmp-30-1" position="float">
<label>Table 1.</label>
<caption xml:lang="en"><p>Comparison of dose calculated by five dose calculation algorithms and measured dose.</p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="center">Modality</th>
<th valign="middle" align="center">Dose calculation algorithms</th>
<th valign="middle" align="center">All (19 OSLDs) [%]</th>
<th valign="middle" align="center">Near PTV (3 OSLDs) [%]</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left">Helical TomoTherapy</td>
<td valign="middle" align="left">CS with VoLO</td>
<td valign="middle" align="center">&#x2212;1.2&#x00B1;3.1</td>
<td valign="middle" align="center">&#x2212;6.8&#x00B1;3.6</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="4">CyberKnife</td>
<td valign="middle" align="left">RT for fixed cone</td>
<td valign="middle" align="center">2.5&#x00B1;7.9</td>
<td valign="middle" align="center">17.9&#x00B1;9.4</td>
</tr>
<tr>
<td valign="middle" align="left">RT with CC for fixed cone</td>
<td valign="middle" align="center">&#x2212;2.8&#x00B1;3.8</td>
<td valign="middle" align="center">&#x2212;0.7&#x00B1;6.8</td>
</tr>
<tr>
<td valign="middle" align="left">MC for fixed cone</td>
<td valign="middle" align="center">&#x2212;1.4&#x00B1;1.8</td>
<td valign="middle" align="center">&#x2212;2.7&#x00B1;2.2</td>
</tr>
<tr>
<td valign="middle" align="left">FSPB for MLC</td>
<td valign="middle" align="center">&#x2212;6.6&#x00B1;8.8</td>
<td valign="middle" align="center">&#x2212;24.3&#x00B1;5.7</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
</back>
</article>