J Korean Ophthalmol Soc JKOS Journal of the Korean Ophthalmological Society 0378-6471 2092-9374 The Korean Ophthalmological Society 10.3341/jkos.2018.59.10.984 Case Report Rapid Progression of the Epiretinal Membrane after Intravitreal Aflibercept Injection Kwon Ji Min MD Lee Myung Shin MD Pak Kang Yeun MD Kim Hyun Woong MD PhD Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. Address reprint requests to Hyun Woong Kim, MD, PhD. Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, #875 Haeundae-ro, Haeundae-gu, Busan 48108, Korea. Tel: 051-797-2310, Fax: 051-797-2030, maekbak@gmail.com 10 2018 17 10 2018 59 10 984 988 08 05 2018 03 07 2018 27 09 2018 ©2018 The Korean Ophthalmological Society 2018 The Korean Ophthalmological Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose

To report a case of rapid progression of the epiretinal membrane following intravitreal aflibercept injection in a patient with exudative age-related macular degeneration.

 Case summary

An 82-year-old female presented with a complaint of decreased visual acuity in her left eye for 1 month. The initial best-corrected visual acuity was 0.2 in the left eye. Fundus examination and optical coherence tomography revealed soft drusen with retinal hemorrhage of the macula and a transparent epiretinal membrane in the left eye. Fluorescein angiography and indocyanine green angiography showed retinal angiomatous proliferation (RAP) of the left eye, so intravitreal aflibercept injection was performed. One month after the first injection, intraretinal cystic macular edema decreased, while transparency of the epiretinal membrane decreased and reflectivity and thickness of the membrane increased. After two additional injections of aflibercept, RAP showed improvement, whereas the epiretinal membrane progressed. Visual acuity of the left eye decreased to 0.1 and vitrectomy of the membrane was performed.

 Conclusions

Careful observation for potentially rapid progression of epiretinal membrane is needed after intravitreal aflibercept injection in the management of exudate age-related macular degeneration accompanied by epiretinal membrane.

 Aflibercept Age-related macular degeneration Epiretinal membrane

The authors have no conflicts to disclose.

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