aard Allergy, Asthma & Respiratory Disease Allergy Asthma Respir Dis 2288-0402 2288-0410 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma 10.4168/aard.2018.6.5.237 aard-6-237 Review Proper allergen selection for serum specific IgE test in children LeeYong Ju 1 YangHyeon-Jong 2 YoonJong-Seo 3 HanMan-Yong 4 KimChang Keun 5 KimJin Tack 3 the Korean Academy of Pediatric Allergy and Respiratory Disease Research Executive Committee Department of Pedaitrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Pediatrics, College of Medicine, The Catholic University, Seoul, Korea Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Bundang, Korea Department of Pediatircs, Inje University Sanggye Paik Hospital, Seoul, Korea Correspondence to: Chang-Keun Kim https://orcid.org/0000-0003-4119-2849 Asthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik Hospital, 1342 Dongil-ro, Nowon-gu, Seoul 01757, Korea Tel: +82-2-950-8832, Fax: +82-2-950-1662, E-mail: kimck@paik.ac.kr 92018 592018 65 237240 26022018 08042018 20042018 Copyright © 2018 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma 2018 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Identifying allergic sensitization is important for the proper diagnosis and management of allergic diseases. Skin prick testing and measuring serum specific IgE antibodies are standard tests to confirm allergic sensitization. Skin prick testing has many advantages, but it is difficult to perform on young children. Serum specific IgE can be easily performed on young children, but it can be performed only up to 12 antigens in patients younger than 6 years due to insurance coverage. Therefore, it is important to select appropriate antigens for the patients. Appropriate allergens may vary depending on the patient's age, accompanying disease, and residential area, so that detailed history taking is essential for proper allergen selection. In this review, we will discuss considerations for selecting appropriate allergens for clinicians when performing an allergy test on difficult-to-test children under 6 years of age.

 Allergens Atopic dermatitis Allergic rhinitis Asthma REFERENCES Song TW Kim KW Kim WK Kim JH Kim HH Park YM Guidelines for the oral food challenges in children Pediatr Allergy Respir Dis 201222420 Kim WK Diagnosis and treatment of food allergy in children Pediatr Allergy Respir Dis 20061627483 Dinakar C Anaphylaxis in children: current understanding and key issues in diagnosis and treatment Curr Allergy Asthma Rep 2012126419 Welch K Chokshi N Wang J Approach to food allergy diagnosis and management by nonspecialty practitioners Ann Allergy Asthma Immunol 20161165858 Bernstein IL Li JT Bernstein DI Hamilton R Spector SL Tan R Allergy diagnostic testing: an updated practice parameter Ann Allergy Asthma Immunol 20081003 Suppl 3S1148 Carr TF Saltoun CA Chapter 2: skin testing in allergy Allergy Asthma Proc 201233 Suppl 168 Hamilton RG Clinical laboratory assessment of immediate-type hyper-sensitivity J Allergy Clin Immunol 20101252 Suppl 2S28496 Jung YH Ko H Kim HY Seo JH Kwon JW Kim BJ Prevalence and risk factors of food allergy in preschool children in Seoul Korean J Asthma Allergy Clin Immunol 20113117783 Sicherer SH Wood RA American Academy of Pediatrics Section On Allergy And Immunology Allergy testing in childhood: using allergen-spe-cific IgE tests Pediatrics 20121291937 Hill DA Spergel JM The atopic march: critical evidence and clinical relevance Ann Allergy Asthma Immunol 20181201317 Kulig M Bergmann R Klettke U Wahn V Tacke U Wahn U Natural course of sensitization to food and inhalant allergens during the first 6 years of life J Allergy Clin Immunol 199910311739 Kim HY Shin YH Yum HY Jee HM Jang SJ Yoon JW Patterns of sensitisation to common food and inhalant allergens and allergic symptoms in pre-school children J Paediatr Child Health 2013492727 Kim NY Kim GR Kim JH Baek JH Yoon JW Jee HM Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children Korean J Pediatr 2015583305 Kim J Hahm MI Lee SY Kim WK Chae Y Park YM Sensitization to aeroallergens in Korean children: a population-based study in 2010 J Korean Med Sci 201126116572 Kim HY Seo JH Jung YH Lee E Yang SI Ha M Sensitization rates to inhalant allergens in children and adolescents of Incheon and Asan area and the relationship between polysensitization and prevalence of allergic diseases Allergy Asthma Respir Dis 20131419 Kim HY Shin YH Han MY Determinants of sensitization to allergen in infants and young children Korean J Pediatr 20145720510 Yoon JW Lee SM Kim JH Kim NY Baek JH Baek HS Sensitization patterns to common allergens in Korean children younger than 6 years of age presenting with typical symptoms or signs of allergic diseases: a single center study Allergy Asthma Respir Dis 201422726 Song A Lee JY Yang HK Kim M Ahn K Lee SI Sensitization in children with atopic dermatitis: a single center study Allergy Asthma Respir Dis 201642905 Kim DH Park YS Jang HJ Kim JH Lim DH Prevalence and allergen of allergic rhinitis in Korean children Am J Rhinol Allergy 201630728 Lee SY Kim KE Pyun BY Ahn K Kim HH Kim JH Research for prevention of food allergy. Research Report for Ministry of Food and Drug Safety Cheongju (Korea) Ministry of Food and Drug Safety 2015 Kim Y Seo JH Kwon JW Lee E Yang SI Cho HJ The prevalence and risk factors of allergic rhinitis from a nationwide study of Korean elementary, middle, and high school students Allergy Asthma Respir Dis 2015327280 Choi MH Kwon EM Kim HB Kim CK Sensitization to inhalant allergens and its association with allergic diseases in preschool children Korean J Asthma Allergy Clin Immunol 20123217682 Kwon SE Lim DH Kim JH Son BK Park YS Jang HJ Prevalence and allergens of allergic rhinitis in children and adolescents in Gwangju Allergy Asthma Respir Dis 201535461 Chiu CY Huang YL Tsai MH Tu YL Hua MC Yao TC Sensitization to food and inhalant allergens in relation to atopic diseases in early childhood: a birth cohort study PLoS One 20149e102809 Kjaer HF Eller E Andersen KE H⊘st A Bindslev-Jensen C The association between early sensitization patterns and subsequent allergic disease. The DARC birth cohort study Pediatr Allergy Immunol 20092072634 Figures and Tables

Allergens for allergic test in infant and preschool children

Food allergy/atopic dermatitis Wheezing/allergic (<3 yr) Wheezing/allergic rhinitis hinitis (3–5 yr)
Egg white D. pteronyssinus D. pteronyssinus
Milk D. farinae D. farinae
Walnut Egg white Cat dander
Wheat Milk Dog dander
Peanut Peanut Altenaria alternata
Soybean Soybean Mold mix (Mx1)
Shrimp Wheat Cockroach
Buckwheat Buckwheat Oak
Fish (Cod) Cat dander Tree pollen mixture (Tx9)
Meat mixture (Fx73) Dog dander Grasss pollen mixture (Gx2)
D. pteronyssinus Mold mix (Mx1) Weed pollen mixture (Wx1)
D. farinae Wee pollen mixture (Wx1) Japanese hop

D. pteronyssinus, Dermatophagoides pteronyssinus; D. farinae, Dermatophagoides farinae.