Pediatr Infect Vaccine PIV Pediatric Infection & Vaccine 2384-1079 2384-1087 The Korean Society of Pediatric Infectious Diseases 10.14776/piv.2016.23.2.117 Original Article Vaccine Evaluation Studies Performed in Korea from 2000 to 2014 Cha Jihei 1 Kim Han Wool 2 Lee Soyoung 1 2 Cho Hye Kyung 3 Ahn Jong Gyun 1 Kim Kyung-Hyo 1 2 Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea. Center for Vaccine Evaluation and Study, Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Korea. Department of Pediatrics, School of Medicine, Gachon University, Incheon, Korea. Corresponding author (kaykim@ewha.ac.kr) 08 2016 25 08 2016 23 2 117 127 29 12 2015 25 02 2016 09 03 2016 Copyright © 2016 The Korean Society of Pediatric Infectious Diseases 2016 Purpose

Vaccine evaluation studies were initiated from 2000 by the Ministry of Food and Drug Safety to produce proper data about the safety and immunogenicity of vaccines. The purpose of this study was to review studies and reports on evaluation of vaccine such as immunogenicity, efficacy, effectiveness, safety and other related topics in order to find and analyze the data on the usefulness of each vaccine.

 Methods

From 2000 to 2014, the project "The vaccine evaluation" had been performed by several researchers, and studies and reports of vaccine evaluation. We reviewed the results and outcomes of studies regarding the evaluation of vaccine's usefulness and analyzed the possibilities of applying these data for establishing vaccine policies. For each vaccine, data analysis and organization were done according to evaluation fields.

 Results

A total of 83 studies were performed on vaccines from 2000 to 2014. For each vaccine, 8 studies were performed on BCG, 14 on DTaP/Td, 1 on poliovirus, 5 on Hib, 3 on pneumococcus, 11 on influenza, 3 on hepatitis A, 11 on MMR, 11 on varicella, and 16 on Japanese encephalitis. All studies were analyzed by the following evaluation area, such as safety, immunogenicity, seroprevalence, persistence of immunity, efficacy, effectiveness, vaccine evaluation methods, quality control product for vaccine, and others.

 Conclusions

Vaccine evaluation studies performed in Korea may be useful as references for establishing vaccination strategy and policy and could be used as baseline data for future studies on vaccine evaluation, vaccine policy establishment, and public/expert vaccine education in Korea.

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