<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "JATS-journalpublishing1.dtd">
<article article-type="case-report" dtd-version="1.0" xml:lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">JRD</journal-id>
<journal-title-group>
<journal-title>Journal of Rheumatic Diseases</journal-title>
<abbrev-journal-title>J Rheum Dis</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">2093-940X</issn>
<issn pub-type="epub">2233-4718</issn>
<publisher>
<publisher-name>The Korean College of Rheumatology</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.4078/jrd.2016.23.2.118</article-id>
<article-id pub-id-type="publisher-id">jrd-23-118</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>A Case of Azygos Vein Thombosis Associated with Transient Antiphospholipid Syndrome in Urinary Tract Infection with <italic>Escherichia coli</italic></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Lee</surname><given-names>Hong Joo</given-names></name>
<xref ref-type="corresp" rid="c1-jrd-23-118"/>
<xref ref-type="aff" rid="aff1-jrd-23-118"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Kang</surname><given-names>Young Mo</given-names></name>
<xref ref-type="aff" rid="aff1-jrd-23-118"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Lee</surname><given-names>Eun</given-names></name>
<xref ref-type="aff" rid="aff1-jrd-23-118"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Jeong</surname><given-names>Byum Jin</given-names></name>
<xref ref-type="aff" rid="aff1-jrd-23-118"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Jo</surname><given-names>Young Jun</given-names></name>
<xref ref-type="aff" rid="aff1-jrd-23-118"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Seong</surname><given-names>Ji Seok</given-names></name>
<xref ref-type="aff" rid="aff1-jrd-23-118"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Woo</surname><given-names>Yong Moon</given-names></name>
<xref ref-type="aff" rid="aff1-jrd-23-118"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en"><surname>Jeong</surname><given-names>Kyung Hwan</given-names></name>
<xref ref-type="aff" rid="aff2-jrd-23-118"><sup>2</sup></xref>
</contrib>
<aff id="aff1-jrd-23-118"><label>1</label>Division of Nephrology, Department of Internal Medicine, Seoul Red Cross Hospital, Kyung Hee University School of Medicine, Seoul, <country>Korea</country></aff>
<aff id="aff2-jrd-23-118"><label>2</label>Department of Nephrology, Kyung Hee University School of Medicine, Seoul, <country>Korea</country></aff>
</contrib-group>
<author-notes>
<corresp id="c1-jrd-23-118"><bold>Corresponding to:</bold> Hong Joo Lee, Division of Nephrology, Department of Internal Medicine, Seoul Red Cross Hospital, 9 Saemunan-ro, Jongno-gu, Seoul 03181, Korea. E-mail: <email>moeru1@naver.com</email></corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>31</day>
<month>10</month>
<year>2016</year>
</pub-date>
<volume>23</volume>
<issue>2</issue>
<fpage>118</fpage>
<lpage>121</lpage>
<history>
<date date-type="received"><day>13</day><month>02</month><year>2015</year></date>
<date date-type="rev-recd"><day>04</day><month>05</month><year>2015</year></date>
<date date-type="rev-recd"><day>04</day><month>06</month><year>2015</year></date>
<date date-type="accepted"><day>04</day><month>06</month><year>2015</year></date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2016 The Korean College of Rheumatology</copyright-statement>
<copyright-year>2016</copyright-year>
<license><license-p>This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license>
</permissions>
<abstract xml:lang="en">
<title>Abstract</title>
<p>A 73-year-old female with diabetes admitted for treatment of an intertrochanter fracture of the femur and a urinary tract infection (UTI) with <italic>Escherichia coli</italic> developed thrombosis in her right azygos vein, which was thought to be associated with anti-phospholipid and immunoglobulin M anticardiolipin antibodies. After antibiotic therapy, antiphospholipid antibody was undetectable, and a repeat chest computed tomography showed complete resolution of the azygos vein thrombosis. A wide variety of infections can be associated with thrombotic events in patients with transient antiphospholipid syndrome (APS), and this case serves as a reminder that the possibility of transient APS should be considered in patients with venous thrombosis in the setting of a UTI.</p>
</abstract>
<kwd-group xml:lang="en">
<kwd>Antiphospholipid syndrome</kwd>
<kwd>Urinary tract infections</kwd>
<kwd><italic>Escherichia coli</italic></kwd>
</kwd-group>
</article-meta>
</front>
<back>
<ref-list xml:lang="en">
<title>REFERENCES</title>
<ref id="b1-jrd-23-118"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cervera</surname> <given-names>R</given-names></name> <name><surname>Piette</surname> <given-names>JC</given-names></name> <name><surname>Font</surname> <given-names>J</given-names></name> <name><surname>Khamashta</surname> <given-names>MA</given-names></name> <name><surname>Shoenfeld</surname> <given-names>Y</given-names></name> <name><surname>Camps</surname> <given-names>MT</given-names></name> <etal/></person-group> <article-title>Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients</article-title> <source>Arthritis Rheum</source> <year>2002</year> <volume>46</volume> <fpage>1019</fpage><lpage>27</lpage></element-citation></ref>
<ref id="b2-jrd-23-118"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cervera</surname> <given-names>R</given-names></name> <name><surname>Asherson</surname> <given-names>RA</given-names></name> <name><surname>Acevedo</surname> <given-names>ML</given-names></name> <name><surname>G&#x00F3;mez-Puerta</surname> <given-names>JA</given-names></name> <name><surname>Espinosa</surname> <given-names>G</given-names></name> <name><surname>De La Red</surname> <given-names>G</given-names></name> <etal/></person-group> <article-title>Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics of 100 patients</article-title> <source>Ann Rheum Dis</source> <year>2004</year> <volume>63</volume> <fpage>1312</fpage><lpage>7</lpage></element-citation></ref>
<ref id="b3-jrd-23-118"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wells</surname> <given-names>PS</given-names></name> <name><surname>Anderson</surname> <given-names>DR</given-names></name> <name><surname>Rodger</surname> <given-names>M</given-names></name> <name><surname>Stiell</surname> <given-names>I</given-names></name> <name><surname>Dreyer</surname> <given-names>JF</given-names></name> <name><surname>Barnes</surname> <given-names>D</given-names></name> <etal/></person-group> <article-title>Excluding pulmonary embolism at the bed-side without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer</article-title> <source>Ann Intern Med</source> <year>2001</year> <volume>135</volume> <fpage>98</fpage><lpage>107</lpage></element-citation></ref>
<ref id="b4-jrd-23-118"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Miyakis</surname> <given-names>S</given-names></name> <name><surname>Lockshin</surname> <given-names>MD</given-names></name> <name><surname>Atsumi</surname> <given-names>T</given-names></name> <name><surname>Branch</surname> <given-names>DW</given-names></name> <name><surname>Brey</surname> <given-names>RL</given-names></name> <name><surname>Cervera</surname> <given-names>R</given-names></name> <etal/></person-group> <article-title>International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)</article-title> <source>J Thromb Haemost</source> <year>2006</year> <volume>4</volume> <fpage>295</fpage><lpage>306</lpage></element-citation></ref>
<ref id="b5-jrd-23-118"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Levine</surname> <given-names>JS</given-names></name> <name><surname>Branch</surname> <given-names>DW</given-names></name> <name><surname>Rauch</surname> <given-names>J</given-names></name></person-group> <article-title>The antiphospholipid syndrome</article-title> <source>N Engl J Med</source> <year>2002</year> <volume>346</volume> <fpage>752</fpage><lpage>63</lpage></element-citation></ref>
<ref id="b6-jrd-23-118"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Misita</surname> <given-names>CP</given-names></name> <name><surname>Moll</surname> <given-names>S</given-names></name></person-group> <article-title>Antiphospholipid antibodies</article-title> <source>Circulation</source> <year>2005</year> <volume>112</volume> <fpage>e39</fpage><lpage>44</lpage></element-citation></ref>
<ref id="b7-jrd-23-118"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dalekos</surname> <given-names>GN</given-names></name> <name><surname>Zachou</surname> <given-names>K</given-names></name> <name><surname>Liaskos</surname> <given-names>C</given-names></name></person-group> <article-title>The antiphospholipid syndrome and infection</article-title> <source>Curr Rheumatol Rep</source> <year>2001</year> <volume>3</volume> <fpage>277</fpage><lpage>85</lpage></element-citation></ref>
<ref id="b8-jrd-23-118"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Asherson</surname> <given-names>RA</given-names></name> <name><surname>Cervera</surname> <given-names>R</given-names></name></person-group> <article-title>Antiphospholipid antibodies and infections</article-title> <source>Ann Rheum Dis</source> <year>2003</year> <volume>62</volume> <fpage>388</fpage><lpage>93</lpage></element-citation></ref>
<ref id="b9-jrd-23-118"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ioannou</surname> <given-names>Y</given-names></name> <name><surname>Giles</surname> <given-names>I</given-names></name> <name><surname>Lambrianides</surname> <given-names>A</given-names></name> <name><surname>Richardson</surname> <given-names>C</given-names></name> <name><surname>Pearl</surname> <given-names>LH</given-names></name> <name><surname>Latchman</surname> <given-names>DS</given-names></name> <etal/></person-group> <article-title>A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli</article-title> <source>BMC Biotechnol</source> <year>2006</year> <volume>6</volume> <fpage>8</fpage></element-citation></ref>
<ref id="b10-jrd-23-118"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cicconi</surname> <given-names>V</given-names></name> <name><surname>Carloni</surname> <given-names>E</given-names></name> <name><surname>Franceschi</surname> <given-names>F</given-names></name> <name><surname>Nocente</surname> <given-names>R</given-names></name> <name><surname>Silveri</surname> <given-names>NG</given-names></name> <name><surname>Manna</surname> <given-names>R</given-names></name> <etal/></person-group> <article-title>Disappearance of antiphospholipid antibodies syndrome after Helicobacter pylori eradication</article-title> <source>Am J Med</source> <year>2001</year> <volume>111</volume> <fpage>163</fpage><lpage>4</lpage></element-citation></ref>
<ref id="b11-jrd-23-118"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Blank</surname> <given-names>M</given-names></name> <name><surname>George</surname> <given-names>J</given-names></name> <name><surname>Fishman</surname> <given-names>P</given-names></name> <name><surname>Levy</surname> <given-names>Y</given-names></name> <name><surname>Toder</surname> <given-names>V</given-names></name> <name><surname>Savion</surname> <given-names>S</given-names></name> <etal/></person-group> <article-title>Ciprofloxacin immunomodulation of experimental anti-phospholipid syndrome associated with elevation of interleukin-3 and granulocyte-macrophage colony-stimulating factor expression</article-title> <source>Arthritis Rheum</source> <year>1998</year> <volume>41</volume> <fpage>224</fpage><lpage>32</lpage></element-citation></ref>
<ref id="b12-jrd-23-118"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kang</surname> <given-names>WS</given-names></name> <name><surname>Min</surname> <given-names>JW</given-names></name> <name><surname>Park</surname> <given-names>SJ</given-names></name> <name><surname>Lee</surname> <given-names>MK</given-names></name> <name><surname>Park</surname> <given-names>CS</given-names></name> <name><surname>Chung</surname> <given-names>JH</given-names></name></person-group> <article-title>A case of septic azygos vein embolism caused by staphylococcus aureus bacteremia</article-title> <source>Tuberc Respir Dis (Seoul)</source> <year>2012</year> <volume>72</volume> <fpage>328</fpage><lpage>31</lpage></element-citation></ref>
<ref id="b13-jrd-23-118"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Okur</surname> <given-names>A</given-names></name> <name><surname>Intepe</surname> <given-names>YS</given-names></name> <name><surname>Serin</surname> <given-names>HI</given-names></name> <name><surname>Y&#x0131; ld&#x0131; r&#x0131;m</surname> <given-names>U</given-names></name> <name><surname>Mavili</surname> <given-names>E</given-names></name></person-group> <article-title>Recurrent pulmonary embolism in an asthmatic patient who had inter-rupted inferior vena cava with azygous continuation</article-title> <source>Turk Kardiyol Dern Ars</source> <year>2014</year> <volume>42</volume> <fpage>277</fpage><lpage>80</lpage></element-citation></ref>
<ref id="b14-jrd-23-118"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hellfritzsch</surname> <given-names>MB</given-names></name></person-group> <article-title>General anatomy and musculoskeletal system</article-title> <source>Acta Radiol</source> <year>2015</year> <volume>56</volume> <fpage>NP24</fpage></element-citation></ref>
<ref id="b15-jrd-23-118"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vallianou</surname> <given-names>N</given-names></name> <name><surname>Lazarou</surname> <given-names>V</given-names></name> <name><surname>Tzangarakis</surname> <given-names>J</given-names></name> <name><surname>Barounis</surname> <given-names>R</given-names></name> <name><surname>Sioula</surname> <given-names>E</given-names></name></person-group> <article-title>Pulmonary embolism as the first manifestation of multiple myeloma</article-title> <source>Case Rep Med</source> <year>2013</year> <year>2013</year> <fpage>236913</fpage></element-citation></ref>
</ref-list>
<sec sec-type="display-objects">
<title>Figures</title>
<fig id="f1-jrd-23-118" position="anchor">
<label>Figure 1.</label>
<caption xml:lang="en"><p>Contrast enhanced chest computed scan, axial image at pulmonary trunk bifurcation and coronal reformation, showed filling defects in the azygos vein (arrows).</p></caption>
<graphic xlink:href="jrd-23-118f1.tif"/>
</fig>
<fig id="f2-jrd-23-118" position="anchor">
<label>Figure 2.</label>
<caption xml:lang="en"><p>Follow-up of chest computed tomography revealed complete resolution of the embolism in the azygos vein (arrows).</p></caption>
<graphic xlink:href="jrd-23-118f2.tif"/>
</fig>
</sec>
</back>
</article>
