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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">JRD</journal-id>
<journal-title-group>
<journal-title>Journal of Rheumatic Diseases</journal-title>
<abbrev-journal-title>J Rheum Dis</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">2093-940X</issn>
<issn pub-type="epub">2233-4718</issn>
<publisher>
<publisher-name>The Korean College of Rheumatology</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.4078/jrd.2011.18.2.94</article-id>
<article-id pub-id-type="publisher-id">jrd-18-94</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>The Prevalence and Features of Korean Gout Patients Using the National Health Insurance Corporation Database</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en">
<surname>Lee</surname><given-names>Chan Hee</given-names></name>
<xref ref-type="aff" rid="aff1-jrd-18-94"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name name-style="western" xml:lang="en">
<surname>Sung</surname><given-names>Na Young</given-names></name>
<xref ref-type="aff" rid="aff2-jrd-18-94"><sup>2</sup></xref>
<xref ref-type="aff" rid="aff3-jrd-18-94"><sup>3</sup></xref>
</contrib>
<aff id="aff1-jrd-18-94" xml:lang="en"><label>1</label>Division of Rheumatology, Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, <country>Korea</country></aff>
<aff id="aff2-jrd-18-94" xml:lang="en"><label>2</label>Institute of Health Insurance and Clinical Research, National Health Insurance Corporation Ilsan Hospital, Goyang, <country>Korea</country></aff>
<aff id="aff3-jrd-18-94" xml:lang="en"><label>3</label>Department of Biostatistics and Computing, Yonsei University, Seoul, <country>Korea</country></aff>
</contrib-group>
<pub-date pub-type="ppub">
<month>6</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub">
<day>31</day>
<month>6</month>
<year>2011</year>
</pub-date>
<volume>18</volume>
<issue>2</issue>
<fpage>94</fpage>
<lpage>100</lpage>
<history>
<date date-type="received"><day>15</day><month>11</month><year>2010</year></date>
<date date-type="revised"><day>21</day><month>12</month><year>2010</year></date>
<date date-type="accepted"><day>22</day><month>12</month><year>2010</year></date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2011 The Korean College of Rheumatology</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract xml:lang="en">
<title>Abstract</title>
<sec>
<title>Objective</title>
<p>We wanted to evaluate the prevalence of gout and its features in Korean people using the National Health Insurance Corporation (NHIC) database.</p>
</sec>
<sec>
<title>Methods</title>
<p>Using the NHIC database from 2001 to 2008, we selected the gout patients who were coded as having gout as a main diagnosis. From the total number of gout patients, we evaluated the prevalence of gout and its features.</p>
</sec>
<sec>
<title>Results</title>
<p>The prevalence of gout prevalence was 0.171% in 2001 and 0.397% in 2008, and there was a 2.317 fold increased during over the 7 years. In 2008, the percentage of fifth and sixth decade patients was 48.5% and that of the male patients were 89.8% of the total gout patients. The increasing rate of the prevalence of gout during the same period was also higher in males (the male vs. female ratio was 5.3:1 in 2001 and 8.8:1 in 2008). The gout prevalence increased year by year to the eighth decade, and the peak prevalence age group was the ninth decade in 2001, the eighth decade in 2002&#x2013;2005 and the seventh decade in 2006&#x2013;2008. The prevalence ratio of 2008 to 2001 was higher for the males and the younger age group; that of third decade for males was 9.87, which was over the 10 times higher compared to that of the ninth decade (9.87 vs. 0.89, respectively).</p>
</sec>
<sec>
<title>Conclusion</title>
<p>The prevalence of gout in 2008 using the NHIC database was 0.397%, so the prevalence of gout increased 2.317 fold over the 7 years, and nearly 90% of the gout patients were male. The increasing rate of gout prevalence was higher in the males and the younger age group.</p>
</sec>
</abstract>
<kwd-group xml:lang="en">
<kwd>Gout</kwd>
<kwd>Prevalence</kwd>
<kwd>Korean</kwd>
<kwd>National Health Insurance Corporation database</kwd>
</kwd-group>
</article-meta>
</front>
<back>
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<ref id="b30-jrd-18-94"><label>30.</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Koh</surname> <given-names>MJ</given-names></name> <name><surname>Han</surname> <given-names>JT</given-names></name> <name><surname>Lee</surname> <given-names>AK</given-names></name> <name><surname>Kim</surname> <given-names>MK</given-names></name> <name><surname>Park</surname> <given-names>SH</given-names></name></person-group> <source>Construction of national health screening examinee cohort - Development of the validity test</source> <fpage>170</fpage> <publisher-loc>Seoul</publisher-loc> <publisher-name>National health insurance corporation</publisher-name> <year>2008</year></element-citation></ref>
<ref id="b31-jrd-18-94"><label>31.</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Park</surname> <given-names>IS</given-names></name> <name><surname>Koh</surname> <given-names>MJ</given-names></name> <name><surname>Kim</surname> <given-names>HJ</given-names></name></person-group> <source>Construction of national health screening examinee cohort - Validity test of National health insurance database (II)</source> <fpage>112</fpage> <publisher-loc>Seoul</publisher-loc> <publisher-name>National health insurance corporation</publisher-name> <year>2009</year></element-citation></ref>
<ref id="b32-jrd-18-94"><label>32.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shin</surname> <given-names>MH</given-names></name> <name><surname>Oh</surname> <given-names>HK</given-names></name> <name><surname>Ahn</surname> <given-names>YO</given-names></name></person-group> <article-title>Ten year trend of cancer incidence in Seoul, Korea: 1993&#x2013;2002</article-title> <source>J Prev Med Public Health</source> <year>2008</year> <volume>41</volume> <fpage>92</fpage><lpage>9</lpage></element-citation></ref>
</ref-list>
<sec sec-type="display-objects">
<title>Figures and Tables</title>
<fig id="F1-jrd-18-94" position="anchor">
<label>Figure 1.</label>
<caption xml:lang="en"><p>Gout prevalence in 2001&#x223C;2008.</p></caption>
<graphic xlink:href="jrd-18-94f1.tif"/>
</fig>
<fig id="F2-jrd-18-94" position="anchor">
<label>Figure 2.</label>
<caption xml:lang="en"><p>Gout prevalence of the total (A) males (B) and females (C) in 2001&#x223C;2008 according to the age group.</p></caption>
<graphic xlink:href="jrd-18-94f2.tif"/>
</fig>
<table-wrap id="T1-jrd-18-94" position="float">
<label>Table 1.</label>
<caption xml:lang="en"><p>Number of gout patients and the prevalence in 2001&#x2013;2008</p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="left" rowspan="2">Year</th>
<th valign="middle" align="center" colspan="2">Total</th>
<th valign="middle" align="center" colspan="2">Male</th>
<th valign="middle" align="center" colspan="2">Female</th>
</tr>
<tr>
<th valign="middle" align="center">Gout patient (n)</th>
<th valign="middle" align="center">Prevalence<sup><xref ref-type="table-fn" rid="table1-fn1-jrd-18-94">&#x2217;</xref></sup> (%)</th>
<th valign="middle" align="center">Gout patient (n)</th>
<th valign="middle" align="center">Prevalence<sup><xref ref-type="table-fn" rid="table1-fn2-jrd-18-94">&#x2020;</xref></sup> (%)</th>
<th valign="middle" align="center">Gout patient (n)</th>
<th valign="middle" align="center">Prevalence<sup><xref ref-type="table-fn" rid="table1-fn3-jrd-18-94">&#x2021;</xref></sup> (%)</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left">2001</td>
<td valign="middle" align="center">80,583</td>
<td valign="middle" align="center">0.1713</td>
<td valign="middle" align="center">67,755</td>
<td valign="middle" align="center">0.2887</td>
<td valign="middle" align="center">12,828</td>
<td valign="middle" align="center">0.0544</td>
</tr>
<tr>
<td valign="middle" align="left">2002</td>
<td valign="middle" align="center">87,586</td>
<td valign="middle" align="center">0.1862</td>
<td valign="middle" align="center">75,443</td>
<td valign="middle" align="center">0.3215</td>
<td valign="middle" align="center">12,143</td>
<td valign="middle" align="center">0.0515</td>
</tr>
<tr>
<td valign="middle" align="left">2003</td>
<td valign="middle" align="center">110,202</td>
<td valign="middle" align="center">0.2343</td>
<td valign="middle" align="center">95,682</td>
<td valign="middle" align="center">0.4078</td>
<td valign="middle" align="center">14,520</td>
<td valign="middle" align="center">0.0616</td>
</tr>
<tr>
<td valign="middle" align="left">2004</td>
<td valign="middle" align="center">121,661</td>
<td valign="middle" align="center">0.2586</td>
<td valign="middle" align="center">106,678</td>
<td valign="middle" align="center">0.4546</td>
<td valign="middle" align="center">14,983</td>
<td valign="middle" align="center">0.0636</td>
</tr>
<tr>
<td valign="middle" align="left">2005</td>
<td valign="middle" align="center">131,798</td>
<td valign="middle" align="center">0.2802</td>
<td valign="middle" align="center">116,706</td>
<td valign="middle" align="center">0.4973</td>
<td valign="middle" align="center">15,092</td>
<td valign="middle" align="center">0.0640</td>
</tr>
<tr>
<td valign="middle" align="left">2006</td>
<td valign="middle" align="center">146,098</td>
<td valign="middle" align="center">0.3106</td>
<td valign="middle" align="center">130,313</td>
<td valign="middle" align="center">0.5553</td>
<td valign="middle" align="center">15,785</td>
<td valign="middle" align="center">0.0670</td>
</tr>
<tr>
<td valign="middle" align="left">2007</td>
<td valign="middle" align="center">165,646</td>
<td valign="middle" align="center">0.3521</td>
<td valign="middle" align="center">148,125</td>
<td valign="middle" align="center">0.6312</td>
<td valign="middle" align="center">17,521</td>
<td valign="middle" align="center">0.0743</td>
</tr>
<tr>
<td valign="middle" align="left">2008</td>
<td valign="middle" align="center">186,705</td>
<td valign="middle" align="center">0.3969</td>
<td valign="middle" align="center">167,718</td>
<td valign="middle" align="center">0.7147</td>
<td valign="middle" align="center">18,987</td>
<td valign="middle" align="center">0.0805</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table1-fn1-jrd-18-94"><label>&#x2217;</label><p>(total number of gout patients)/(total population in 2005)&#x00D7;100,</p></fn>
<fn id="table1-fn2-jrd-18-94"><label>&#x2020;</label><p>(total number of male gout patients)/(total number of males in 2005) &#x00D7;100,</p></fn>
<fn id="table1-fn3-jrd-18-94"><label>&#x2021;</label><p>(total number of female gout patients)/(total number of females in 2005)&#x00D7;100.</p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T2-jrd-18-94" position="float">
<label>Table 2.</label>
<caption xml:lang="en"><p>Gout prevalence per 100,000 people and the gender ratio in 2001&#x2013;2008</p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="center" rowspan="2">Year</th>
<th valign="middle" align="center" colspan="3">Prevalence per 100,000</th>
<th valign="middle" align="center" rowspan="2">Prevalence ratio of males vs females<sup><xref ref-type="table-fn" rid="table2-fn3-jrd-18-94">&#x2021;</xref></sup></th>
</tr>
<tr>
<th valign="middle" align="center">Total</th>
<th valign="middle" align="center">Male (n)<sup><xref ref-type="table-fn" rid="table2-fn1-jrd-18-94">&#x2217;</xref></sup></th>
<th valign="middle" align="center">Female (n)<sup><xref ref-type="table-fn" rid="table2-fn2-jrd-18-94">&#x2020;</xref></sup></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left">2001</td>
<td valign="middle" align="center">171.3</td>
<td valign="middle" align="center">144.0</td>
<td valign="middle" align="center">27.3</td>
<td valign="middle" align="center">5.3</td>
</tr>
<tr>
<td valign="middle" align="left">2002</td>
<td valign="middle" align="center">186.2</td>
<td valign="middle" align="center">160.4</td>
<td valign="middle" align="center">25.8</td>
<td valign="middle" align="center">6.2</td>
</tr>
<tr>
<td valign="middle" align="left">2003</td>
<td valign="middle" align="center">234.3</td>
<td valign="middle" align="center">203.4</td>
<td valign="middle" align="center">30.9</td>
<td valign="middle" align="center">6.6</td>
</tr>
<tr>
<td valign="middle" align="left">2004</td>
<td valign="middle" align="center">258.6</td>
<td valign="middle" align="center">226.8</td>
<td valign="middle" align="center">31.9</td>
<td valign="middle" align="center">7.1</td>
</tr>
<tr>
<td valign="middle" align="left">2005</td>
<td valign="middle" align="center">280.2</td>
<td valign="middle" align="center">248.1</td>
<td valign="middle" align="center">32.1</td>
<td valign="middle" align="center">7.7</td>
</tr>
<tr>
<td valign="middle" align="left">2006</td>
<td valign="middle" align="center">310.6</td>
<td valign="middle" align="center">277.0</td>
<td valign="middle" align="center">33.6</td>
<td valign="middle" align="center">8.3</td>
</tr>
<tr>
<td valign="middle" align="left">2007</td>
<td valign="middle" align="center">352.1</td>
<td valign="middle" align="center">314.9</td>
<td valign="middle" align="center">37.2</td>
<td valign="middle" align="center">8.5</td>
</tr>
<tr>
<td valign="middle" align="left">2008</td>
<td valign="middle" align="center">396.9</td>
<td valign="middle" align="center">356.5</td>
<td valign="middle" align="center">40.4</td>
<td valign="middle" align="center">8.8</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table2-fn1-jrd-18-94"><label>&#x2217;</label><p>(total number of male gout patients)/(total population in 2005) &#x00D7;10<sup>5</sup>,</p></fn>
<fn id="table2-fn2-jrd-18-94"><label>&#x2020;</label><p>(total number of female gout patients)/(total population in 2005)&#x00D7;10<sup>5</sup>,</p></fn>
<fn id="table2-fn3-jrd-18-94"><label>&#x2021;</label><p>The reference is the females.</p></fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T3-jrd-18-94" position="float">
<label>Table 3.</label>
<caption xml:lang="en"><p>Comparison of the gout prevalence between 2001 and 2008 according to the age group and gender</p></caption>
<table frame="hsides" rules="all">
<thead>
<tr>
<th valign="middle" align="center">&#x00A0;</th>
<th valign="middle" align="center">Age group</th>
<th valign="middle" align="center">Prevalence in 2001 (%)</th>
<th valign="middle" align="center">Prevalence in 2008 (%)</th>
<th valign="middle" align="center">Prevalence ratio of 2001 vs 2008</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left">Total</td>
<td valign="middle" align="center">20&#x223C;29</td>
<td valign="middle" align="center">0.0174</td>
<td valign="middle" align="center">0.1234</td>
<td valign="middle" align="center">7.11</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">30&#x223C;39</td>
<td valign="middle" align="center">0.0831</td>
<td valign="middle" align="center">0.3506</td>
<td valign="middle" align="center">4.22</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">40&#x223C;49</td>
<td valign="middle" align="center">0.2101</td>
<td valign="middle" align="center">0.5681</td>
<td valign="middle" align="center">2.70</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">50&#x223C;59</td>
<td valign="middle" align="center">0.3965</td>
<td valign="middle" align="center">0.8770</td>
<td valign="middle" align="center">2.21</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">60&#x223C;69</td>
<td valign="middle" align="center">0.5188</td>
<td valign="middle" align="center">0.9779</td>
<td valign="middle" align="center">1.88</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">70&#x223C;79</td>
<td valign="middle" align="center">0.6054</td>
<td valign="middle" align="center">0.9183</td>
<td valign="middle" align="center">1.52</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">&#x2265;80</td>
<td valign="middle" align="center">0.6314</td>
<td valign="middle" align="center">0.5643</td>
<td valign="middle" align="center">0.89</td>
</tr>
<tr>
<td valign="middle" align="left">Male</td>
<td valign="middle" align="center">20&#x223C;29</td>
<td valign="middle" align="center">0.0214</td>
<td valign="middle" align="center">0.2108</td>
<td valign="middle" align="center">9.87</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">30&#x223C;39</td>
<td valign="middle" align="center">0.1344</td>
<td valign="middle" align="center">0.6449</td>
<td valign="middle" align="center">4.80</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">40&#x223C;49</td>
<td valign="middle" align="center">0.3538</td>
<td valign="middle" align="center">1.0256</td>
<td valign="middle" align="center">2.90</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">50&#x223C;59</td>
<td valign="middle" align="center">0.6791</td>
<td valign="middle" align="center">1.5896</td>
<td valign="middle" align="center">2.34</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">60&#x223C;69</td>
<td valign="middle" align="center">0.9586</td>
<td valign="middle" align="center">1.8967</td>
<td valign="middle" align="center">1.98</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">70&#x223C;79</td>
<td valign="middle" align="center">1.3258</td>
<td valign="middle" align="center">2.0406</td>
<td valign="middle" align="center">1.54</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">&#x2265;80</td>
<td valign="middle" align="center">1.6893</td>
<td valign="middle" align="center">1.4996</td>
<td valign="middle" align="center">0.89</td>
</tr>
<tr>
<td valign="middle" align="left">Female</td>
<td valign="middle" align="center">20&#x223C;29</td>
<td valign="middle" align="center">0.0131</td>
<td valign="middle" align="center">0.0308</td>
<td valign="middle" align="center">2.34</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">30&#x223C;39</td>
<td valign="middle" align="center">0.0312</td>
<td valign="middle" align="center">0.0532</td>
<td valign="middle" align="center">1.70</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">40&#x223C;49</td>
<td valign="middle" align="center">0.0640</td>
<td valign="middle" align="center">0.1032</td>
<td valign="middle" align="center">1.61</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">50&#x223C;59</td>
<td valign="middle" align="center">0.1169</td>
<td valign="middle" align="center">0.1718</td>
<td valign="middle" align="center">1.47</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">60&#x223C;69</td>
<td valign="middle" align="center">0.1393</td>
<td valign="middle" align="center">0.1849</td>
<td valign="middle" align="center">1.33</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">70&#x223C;79</td>
<td valign="middle" align="center">0.1475</td>
<td valign="middle" align="center">0.2050</td>
<td valign="middle" align="center">1.39</td>
</tr>
<tr>
<td valign="middle" align="left">&#x00A0;</td>
<td valign="middle" align="center">&#x2265;80</td>
<td valign="middle" align="center">0.1913</td>
<td valign="middle" align="center">0.1753</td>
<td valign="middle" align="center">0.92</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
</back>
</article>