J Korean Diabetes Assoc JKDA The Journal of Korean Diabetes Association 1015-6461 Korean Diabetes Association 10.4093/jkda.2007.31.6.507 Original Articles The Plasma Adiponectin Levels in Patients with Newly Diagnosed Type 2 Diabetes Lee Ihn Suk Kim Yun Jeung Kim Jong Im 1 Park Jea Hyung Ku Bon Jeong Park Kang Seo 2 Lee Tae Yong 1 Kim Young Kun Department of Internal Medicine, Chungnam National University School of Medicine, Korea. Department of Preventive Medicine, Chungnam National University School of Medicine, Korea. Department of Internal Medicine, Eulji University School of Medicine, Korea. 11 2007 30 11 2007 31 6 507 516 01 08 2007 14 11 2007 Copyright © 2007 Korean Diabetes Association 2007 Background

Adiponectin is secreted from adipose tissue and plays an important role in the regulation of glycemia and insulin resistance. In this study, the relationship between adiponectin and the adiposity, body composition, insulin sensitivity, lipid profile were respectively examined in newly diagnosed type 2 diabetes.

 Methods

Total 1993 were participated in the Korea Rural Genomic Cohort Study (Geumsan County). After a 12-hour overnight fast, all subjects underwent 75-g oral glucose tolerance test. 105 of those were studied as newly diagnosed type 2 diabetes. The body composition was analyzed by means of bioelectric impedance analysis and the insulin sensitivity was estimated by fasting insulin, HOMA-IR and QUICKI method, respectively.

 Results

Adiponectin positively correlated with high-density lipoprotein cholesterol (r = 0.246, P < 0.05). Adiponectin inversely associated with waist circumference (r = -0.408, P < 0.01), triglyceride (r = -0.274, P < 0.05), ferritin (r = -0.260, P < 0.05), visceral fat (r = -0.248, P < 0.05), high sensitivity C-reactive protein (r = -0.228, P < 0.05) and body mass index (r = -0.225, P < 0.05). In multiple linear regression, waist circumference and high-density lipoprotein cholesterol were analyzed as independent variables of serum adiponectin.

 Conclusion

Adiponectin concentrations were closely related to waist circumference in newly diagnosed type 2 diabetes.

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Baseline characteristics of the study subjects

Data were means ± SD. 2h-glucose and 2h-insulin represent glucose and insulin concentrations at 120 min after a glucose challenge. BMI, Body mass index; BP, blood pressure; HDL-cholesterol, high-density lipoprotein cholesterol; LDL-cholesterol, low-density lipoprotein cholesterol; baPWV, brachial-ankle pulse wave velocity; HOMA-IR, homeostasis model for insulin resistance; QUICKI, quantitative insulin sensitivity check index.

Anthropometric and clinical characteristics of newly diagnosed diabetes according to BMI

Data were means ± SD. 2h-glucose and 2h-insulin represent glucose and insulin concentrations at 120 min after a glucose challenge. BMI, Body mass index; BP, blood pressure; HDL-cholesterol, high-density lipoprotein cholesterol; LDL-cholesterol, low-density lipoprotein cholesterol; baPWV, brachial-ankle pulse wave velocity; HOMA-IR, homeostasis model for insulin resistance; QUICKI, quantitative insulin sensitivity check index.

Anthropometric and clinical characteristics by serum adiponectin concentrations tertile

Data were means ± SD. 2h-glucose and 2h-insulin represent glucose and insulin concentrations at 120 min after a glucose challenge. BMI, Body mass index; BP, blood pressure; HDL-cholesterol, high-density lipoprotein cholesterol; LDL-cholesterol, low-density lipoprotein cholesterol; baPWV, brachial-ankle pulse wave velocity; HOMA-IR, homeostasis model for insulin resistance; QUICKI, quantitative insulin sensitivity check index.

Correlation between adiponectin and blood lipid, anthropometric variables, surrogate of insulin resistance in new diagnosed type 2 Diabetes

2h-glucose and 2h-insulin represent glucose and insulin concentrations at 120 min after a glucose challenge Data were means ± SD. 2h-glucose and 2h-insulin represent glucose and insulin concentrations at 120 min after a glucose challenge. BMI, Body mass index; BP, blood pressure; HDL-cholesterol, high-density lipoprotein cholesterol; LDL-cholesterol, low-density lipoprotein cholesterol; baPWV, brachial-ankle pulse wave velocity; HOMA-IR, homeostasis model for insulin resistance; QUICKI, quantitative insulin sensitivity check index. Data were Pearson's correlation(r) coefficients adjusted for age and sex and standardized Coefficeients(β) using multivariate regression analysis. *P < 0.01. **P < 0.05.

Multiple regression analysis of the variables; Adiponectin as the dependent variable