J Korean Diabetes Assoc JKDA The Journal of Korean Diabetes Association 1015-6461 Korean Diabetes Association 10.4093/jkda.2007.31.6.455 Original Articles Association of Kir6.2 and Peroxisome Proliferator-activated Receptor-gamma (PPARγ) Polymorphisms with Type 2 Diabetes in Koreans Lee Jung Eun Kim Su Won 1 Seo Hyun Ae Jeon Jae Han Moon Seong Su Kim Hee Kyung Doh Yun Jeong Kim Bo Wan Kim Jung Guk Yoo Min 2 Lee In Kyu Department of Internal Medicine, Kyungpook National University School of Medicine, Korea. Medical Education Program For Human Resources, Kyungpook National University, Korea. Department of Biology, College of Natural Science, Keimyung University, Korea. 11 2007 30 11 2007 31 6 455 464 15 05 2007 02 10 2007 Copyright © 2007 Korean Diabetes Association 2007 Background

The type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Several variants may contribute significantly to the risk of type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys). In this study, we evaluated the association of Pro12Ala variant of the peroxisome proliferator-activated receptor-γ and the Glu23Lys variant of the ATP-sensitive potassium channel, Kir6.2 (KCNJ11) with the type 2 diabetes in Korean population.

 Method

This study included 331 subjects consisting of 172 patients with type 2 diabetes and 159 non-diabetic control subjects enrolled from the Kyungpook, Keimyung and Catholic university hospital in Daegu, Korea. We genotyped Kir6.2 (Glu23Lys) and PPARγ (Pro12Ala) polymorphism and examined their association with the type 2 diabetes.

 Result

In the separate analyses, the Kir6.2 Glu23Lys (P = 0.385) and the PPARγ Pro12Ala (P = 0.191) polymorphism showed no significant association with type 2 diabetes. In addition, the results of our study showed no evidence of a synergistic interaction between Kir6.2 and PPARγ gene in each group (P = 0.110, P = 0.276).

 Conclusion

In this study, no association was seen between the genetic polymorphisms of Kir6.2, PPARγ and type 2 diabetes. However, to clarify whether genetic polymorphisms of these genes contribute to the development of type 2 diabetes, further studies involving larger Korean populations may be needed.

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Dermographic and health behavior variables among study subjects

*expressed as mean ± SD. †P < 0.05.

Genotype and allele frequencies of Kir 6.2 gene in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.

Genotype frequencies of Kir 6.2 gene by gender in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.

Genotype and allele frequencies of PPARγ gene in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.

Genotype frequencies of PPARγ gene by gender in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.

Distribution of the genotype combination of Kir6.2 and PPARγ genes in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.