Tuberc Respir Dis TRD Tuberculosis and Respiratory Diseases 0378-0066 The Korean Academy of Tuberculosis and Respiratory Diseases 10.4046/trd.2004.56.2.144 Original Article The Time Responses of Spirometric Values in Response to Single Doses of Inhaled Salbutamol Park Sun Hyo M.D. Choi Won Il M.D. Lee Sang Won M.D. Park Hun Pyo M.D. Seo Yong Woo M.D. Ku Duk Hee Lee Mi Young M.D. 1 Lee Choong Won M.D. 1 Jeon Young June M.D. Department of Medicine, Keimyung University School of Medicine, Taegu, Korea. Department of PreventiveMedicine, Keimyung University School of Medicine, Taegu, Korea. Address for correspondence: Won-Il Choi, M.D. Department of Medicine, Keimyung University School of Medicine 194 Dongsan-Dong, Jung-Gu, Daegu, 700-712, Korea. Phone: +82-53-250-7405, Fax: +82-53-250-7434, wichoi@dsmc.or.kr 02 2004 29 02 2004 56 2 144 150 Copyright©2004. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. 2004 Background

An assessment of the presence and the degree of reversibility of airflow obstruction is clinically important in patients with asthma or chronic obstructive pulmonary disease. However, the time responses of spirometric parameters in response to bronchodilator have not been well investigated.

 Methods

We studied 15 patients with asthma. Spirometric and mini-Wright peak expiratory flow measurements were performed at 15, 30, 45, and 60 minutes after using single dose(200 µg) of inhaled bronchodilator, salbutamol.

 Results

The mean values of forced expiratory volume in one second(FEV1) and forced vital capicaty(FVC) were significantly increased at 60 minutes after using bronchodilator in comparison to 15 minutes. And peak expiratory flow rate measured by either mass flow sensor or mini-Wright peak flow meter were significantly increased at 45 minutes after using bronchodilator in comparison to 15 minutes.

 Conclusions

To appropriate evaluation of the bronchodilator response in patients with reversible airflow limitation, it would be useful measuring either FEV1 or PEF at the later time point 60 or 45 minutes in comparison to 15 minutes after using bronchodilator.

 PEF FEV1 Reversibility of airflow obstruction Salbutamol Asthma