<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM/DTD Journal Publishing DTD v2.3 20070202//EN" "journalpublishing.dtd">
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	<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Yonsei Med J</journal-id>
<journal-id journal-id-type="publisher-id">YMJ</journal-id>
<journal-title>Yonsei Medical Journal</journal-title>
<issn pub-type="ppub">0513-5796</issn>
<publisher>
<publisher-name>Yonsei University College of Medicine</publisher-name>
</publisher>
</journal-meta>
		<article-meta>
			<article-id pub-id-type="doi">10.3349/ymj.2003.44.4.608</article-id>
			<article-categories>
				<subj-group>
					<subject>Original Article</subject>
				</subj-group>
			</article-categories>
			<title-group>
				<article-title>Hypothalamic-Pituitary-Adrenal Reactivity in Boys with Attention Deficit Hyperactivity Disorder</article-title>
			</title-group>
			<contrib-group>
				<contrib contrib-type="author">
					<name>
						<surname>Hong</surname>
						<given-names>Hyun Ju</given-names>
					</name>
					<xref ref-type="aff" rid="A1">1</xref>
				</contrib>
				<contrib contrib-type="author" corresp="yes">
					<name>
						<surname>Shin</surname>
						<given-names>Dong Won</given-names>
					</name>
					<xref ref-type="aff" rid="A2">2</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Lee</surname>
						<given-names>Eun Ha</given-names>
					</name>
					<xref ref-type="aff" rid="A2">2</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Oh</surname>
						<given-names>Youn Hee</given-names>
					</name>
					<xref ref-type="aff" rid="A2">2</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Noh</surname>
						<given-names>Kyung Sun</given-names>
					</name>
					<xref ref-type="aff" rid="A2">2</xref>
				</contrib>
				</contrib-group>
				<aff id="A1"><label>1</label>Department of Psychiatry, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.</aff>
				<aff id="A2"><label>2</label>Department of Psychiatry, Kangbuk Samsung Hospital, SungKyunKwan University School of Medicine, Seoul, Korea.</aff>
				<author-notes>
					<corresp>Reprint address: requests to Dr. Dong Won Shin, Department of Psychiatry, SungKyunKwan University School of Medicine, Kangbuk Samsung Hospital, 108 Pyung-dong, Jongro-gu Seoul 110-102, Korea. Tel: 82-2-2001-2213/2465, Fax: 082-2-2001-2211, <email>ntour@unitel.co.kr</email>
					</corresp>
				</author-notes>
			<pub-date pub-type="ppub">
				<month>08</month>
				<year>2003</year>
			</pub-date>
			<pub-date pub-type="epub">
				<day>30</day>
				<month>03</month>
				<year>2009</year>
			</pub-date>
			<volume>44</volume>
			<issue>4</issue>
			<fpage>608</fpage>
			<lpage>614</lpage>
			<history>
				<date date-type="received">
					<day>08</day>
					<month>01</month>
					<year>2003</year>
				</date>
				<date date-type="accepted">
					<day>10</day>
					<month>05</month>
					<year>2003</year>
				</date>
			</history>
			<permissions>
				<copyright-statement>Copyright &#x00A9; 2003 The Yonsei University College of Medicine</copyright-statement>
				<copyright-year>2003</copyright-year>
			</permissions>
			<abstract>
				<p>The hypothesis 'whether subjects with attention-deficit/hyperactivity disorder (ADHD), who showed under-reactivity of the hypothalamic-pituitary-adrenal (HPA) axis to stress, would make more commission errors in attention tasks', was examined. Forty-three boys, with ADHD, who visited the psychiatric outpatient clinic, at Kangbuk Samsung Hospital, were the subjects of this study. Both pre- and post-test morning saliva samples were collected from the patients at the Korean Educational Development Institute-Wechsler Intelligence Scale for Children (KEDI-WISC), and Tests of Variables of Attention (T.O.V.A.) performed. The Standard scores of the T.O.V.A were compared between the patients with decreases, or increases, in the salivary cortisol levels after the test. Decreases, or increases in the salivary cortisol levels after the test were shown in 28 and 15 patients, respectively. The patients with decreased cortisol levels after the test tended to make more commission errors in compared with those with increased cortisol levels. The patients with the decreased cortisol levels after test had more omission errors in the first quarter of the test, and more commission errors in the second half of the test compared to those with the increased cotisol levels. Subjects who show decreased salivary cortisol levels after stress make more commission errors in attention tests. This suggests that the blunted HPA axis response to stress is related to the impulsivity in patients with ADHD.</p>
			</abstract>
			<kwd-group>
				<kwd>ADHD</kwd>
				<kwd>HPA axis reactivity</kwd>
				<kwd>impulsivity</kwd>
			</kwd-group>

		</article-meta>
	</front>
</article>
