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<article article-type="case-report" xml:lang="EN">

<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">J Korean Med Sci</journal-id>
<journal-id journal-id-type="publisher-id">JKMS</journal-id>
<journal-title-group>
<journal-title>Journal of Korean Medical Science</journal-title>
</journal-title-group>
<issn pub-type="ppub">1011-8934</issn>
<issn pub-type="epub">1598-6357</issn>
<publisher>
<publisher-name>The Korean Academy of Medical Sciences</publisher-name>
</publisher>
</journal-meta>

<article-meta>
<article-id pub-id-type="doi">10.3346/jkms.2016.31.4.644</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Images in This Issue</subject>
<subj-group subj-group-type="subheading">
<subject>Otorhinolaryngology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Isolated Parotid Gland Sarcoidosis Mimicking Parotid Tumor</article-title>
</title-group>

<contrib-group>

<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-9288-5368</contrib-id>
<name>
<surname>Lee</surname>
<given-names>Dong Hoon</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-2207-6693</contrib-id>
<name>
<surname>Kim</surname>
<given-names>Jo Heon</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>

<contrib contrib-type="author" corresp="yes">
<contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-7542-9616</contrib-id>
<name>
<surname>Lee</surname>
<given-names>Joon Kyoo</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>

</contrib-group>

<aff id="A1"><label>1</label>Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School &amp; Chonnam National University Hwasun Hospital, Hwasun, <country>Korea</country>.</aff>
<aff id="A2"><label>2</label>Department of Pathology, Chonnam National University Medical School &amp; Chonnam National University Hwasun Hospital, Hwasun, <country>Korea</country>.</aff>

<author-notes>
<corresp>Address for Correspondence: Joon Kyoo Lee, MD. Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun 58128, Korea. <email>joonkyoo@jnu.ac.kr</email></corresp>
</author-notes>

<pub-date pub-type="ppub">
<month>04</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>08</day>
<month>03</month>
<year>2016</year>
</pub-date>
<volume>31</volume>
<issue>4</issue>
<fpage>644</fpage>
<lpage>645</lpage>

<history>
<date date-type="received">
<day>22</day>
<month>08</month>
<year>2015</year>
</date>
<date date-type="accepted">
<day>14</day>
<month>01</month>
<year>2016</year>
</date>
</history>

<permissions>
<copyright-statement>&#x00A9; 2016 The Korean Academy of Medical Sciences.</copyright-statement>
<copyright-year>2016</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">
<license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>



</article-meta>

</front>

<body>
<p>A 49-year-old female presented to our department with right infra-auricular swelling present for more than 3 weeks. The patient&#x2019;s medical history was not remarkable. The patient had no fever, cough, stridor, dyspnea, shortness of breath, rash, and dryness of mouth or eyes, weight loss, convulsions, or previous hospital admissions. The family history was unremarkable. Physical examination revealed a solitary, firm, non-tender, mobile, and approximately 2-cm sized mass of the right parotid gland. The overlying skin was normal in appearance without erythema or induration. The patient had no cranial nerve deficits and no cervical lymphadenopathy. Computed tomography (CT) scan of the neck demonstrated about 2.2 &#x00D7; 2.1 &#x00D7; 2.2 cm heterogeneously enhancing mass in the right parotid gland (<xref ref-type="fig" rid="F1">Fig. 1A</xref>). Fine-needle aspiration cytology (FNAC) under ultrasound showed chronic granulomatous inflammation. Based on these observations, the preoperative diagnosis was a right-side parotid tumor.</p>
<p>We performed the superficial parotidectomy with preserving facial nerve through a standard &#x2018;lazy S&#x2019; cervico-mastoid preauricular surgical incision. The post-operative course was uneventful. The histopathological analysis of the parotid mass demonstrated non-necrotizing granulomatous inflammation suggestive of sarcoidosis (<xref ref-type="fig" rid="F1">Fig. 1B</xref>). Staining of the excised tissues was negative for acid-fast bacilli, and special stains for mycobacteria and fungus revealed no microorganisms. We consulted a pulmonologist and ophthalmologist. Ophthalmologic examinations and radiologic examinations (chest and abdomen CT) revealed no evidence of lung sarcoidosis. The final diagnosis made was parotid gland sarcoidosis. The patient has been regularly followed up usually every 6 months with ophthalmologic and radiologic examinations to check for occurrence of sarcoidosis.</p>

<sec>
<title>Ethics statement</title>
<p>The authors obtained approval from the institutional review board of Chonnam National University Hwasun Hospital (CNUHH-2016-005).</p>
</sec>

</body>

<back>

<fn-group>
<fn fn-type="conflict">
<label>DISCLOSURE</label>
<p>The authors have no potential conflicts of interest to disclose.</p>
</fn>

<fn fn-type="participating-researchers">
<label>AUTHOR CONTRIBUTION</label>
<p>Study concept and design: Lee DH. Data collection and analysis: Kim JH. Drafting of manuscript and critical revision: Lee DH, Lee JK. Revision: Kim JH. Approval of final version of manuscript: all authors.</p>
</fn>
</fn-group>

</back>

<floats-group>

<fig id="F1" position="float" fig-type="figure">
<label>Fig. 1</label>
<caption>
<p>Supportive findings for diagnosis of the patient. (<bold>A</bold>) Neck CT scans demonstrate a 2.2 &#x00D7; 2.1 &#x00D7; 2.2 cm heterogeneously enhancing mass (arrow) in the right parotid gland. (<bold>B</bold>) Histological examination of the specimen reveals non-necrotizing coalescing granulomas, composed of epithelioid cells and scattered multinucleated giant cells (arrow). The multinucleated giant cells are of Langhans type. Mature lymphoplasma cells form a concentric rim around the granuloma. Granulomatous inflammation irregularly infiltrates normal salivary parenchyma and peri-parotid soft tissue (Hematoxylin and eosin stained, &#x00D7; 100).</p>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="jkms-31-644-g001"></graphic>
</fig>

</floats-group>

</article>