<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "JATS-journalpublishing1.dtd">
<article article-type="research-article" dtd-version="1.0" xml:lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">JKOS</journal-id>
<journal-title-group>
<journal-title>Journal of the Korean Ophthalmological Society</journal-title>
<abbrev-journal-title>J Korean Ophthalmol Soc</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">0378-6471</issn>
<issn pub-type="epub">2092-9374</issn>
<publisher>
<publisher-name>Korean Ophthalmological Society</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3341/jkos.2018.59.4.388</article-id>
<article-id pub-id-type="publisher-id">jkos-59-388</article-id>
<article-categories>
<subj-group>
<subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Abducens Nerve Palsy Caused by the Ophthalmic Segment of an Internal Carotid Artery Aneurysm</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name name-style="western" xml:lang="en"><surname>Kim</surname><given-names>Inhye</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1-jkos-59-388"><sup>1</sup></xref></contrib>
<contrib contrib-type="author"><name name-style="western" xml:lang="en"><surname>Kim</surname><given-names>Jong Hoon</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2-jkos-59-388"><sup>2</sup></xref></contrib>
<contrib contrib-type="author"><name name-style="western" xml:lang="en"><surname>Kim</surname><given-names>Won Jae</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1-jkos-59-388"><sup>1</sup></xref><xref ref-type="corresp" rid="c1-jkos-59-388"/></contrib>
<aff id="aff1-jkos-59-388" xml:lang="en"><label><sup>1</sup></label>Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, <country>Korea</country></aff>
<aff id="aff2-jkos-59-388" xml:lang="en"><label><sup>2</sup></label>Department of Neurosurgery, Yeungnam University College of Medicine, Daegu, <country>Korea</country></aff>
</contrib-group>
<author-notes>
<corresp id="c1-jkos-59-388">Address reprint requests to <bold>Won Jae Kim, MD</bold> Department of Ophthalmology, Yeungnam University Hospital, &#x0023;170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea Tel: 82-53-620-4191, Fax: 82-53-626-5936, E-mail: <email>eyekwj@ynu.ac.kr</email></corresp>
</author-notes>
<pub-date pub-type="ppub"><month>9</month><year>2018</year></pub-date>
<pub-date pub-type="epub"><day>7</day><month>9</month><year>2018</year></pub-date>
<volume>59</volume>
<issue>4</issue>
<fpage>388</fpage>
<lpage>392</lpage>
<history>
<date date-type="received"><day>9</day><month>11</month><year>2017</year></date>
<date date-type="rev-recd"><day>5</day><month>12</month><year>2017</year></date>
<date date-type="accepted"><day>22</day><month>03</month><year>2018</year></date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2018 Korean Ophthalmological Society</copyright-statement>
<copyright-year>2018</copyright-year>
<license><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license>
</permissions>
<abstract xml:lang="en">
<title>Abstract</title>
<sec><title>Purpose</title>
<p>To report a case of isolated abducens nerve palsy caused by the ophthalmic segment of an internal carotid artery (ICA) aneurysm which improved after endovascular coil trapping.</p>
</sec>
<sec><title>Case summary</title>
<p>A 59-year-old female visited the ophthalmology department for a sudden onset of horizontal diplopia for 10 days. The best corrected visual acuity was 20/20 in both eyes. The pupils showed normal response to light and near stimulation in both eyes. The extraocular examination showed 35 prism diopters left esotropia at primary gaze and &#x2212;4 abduction limitation of the left eye. The patient suffered intermittent headaches in the left temporal area and left retrobulbar pain for 1 month. Magnetic resonance imaging with magnetic resonance angiography of the brain was performed. A focal protruding lesion of the left ICA suggested an aneurysm. The patient consulted with the neurosurgery department. The left ophthalmic segment of the ICA aneurysm was confirmed by transfemoral cerebral angiography and treated with coil placement and the patient showed gradual improvement after the procedure. Three months after the procedure there was no diplopia. The patient showed orthotropia at primary gaze without abduction limitation.</p>
</sec>
<sec><title>Conclusions</title>
<p>Isolated abducens nerve palsy can be caused by the ophthalmic segment of an ICA aneurysm, which should be considered in the differential diagnosis of ocular motility disorders. The disorder improved with coil replacement treatment. Differential diagnosis as a cause of abducens nerve palsy is important for prompt and appropriate treatment. Neuroimaging should be considered in patients with isolated abducens nerve palsy with a non-ischemic origin.</p>
</sec>
</abstract>
<kwd-group xml:lang="en">
<kwd>Abducens nerve palsy</kwd>
<kwd>Aneurysm</kwd>
<kwd>Diplopia</kwd>
<kwd>Internal carotid artery</kwd>
</kwd-group>
</article-meta>
</front>
<back>
<ref-list><title>REFERENCES</title>
<ref id="b1-jkos-59-388"><label>1)</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Miller</surname><given-names>NR</given-names></name><name><surname>Subramanian</surname><given-names>PS</given-names></name><name><surname>Patel</surname><given-names>VR</given-names></name></person-group><article-title>Walsh and Hoyt&#x0027;s Clinical Neuro-Ophthalmology: the essentials</article-title><edition>3rd</edition><publisher-loc>Philadelphia</publisher-loc><publisher-name>Wolters Kluwer</publisher-name><year>2016</year><fpage>361</fpage><lpage>9</lpage></element-citation></ref>
<ref id="b2-jkos-59-388"><label>2)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jeon</surname><given-names>C</given-names></name><name><surname>Sa</surname><given-names>HS</given-names></name><name><surname>Oh</surname><given-names>SY</given-names></name></person-group><article-title>Causes and natural course of the sixth cranial nerve palsy</article-title><source>J Korean Ophthalmol Soc</source><year>2006</year><volume>47</volume><fpage>1776</fpage><lpage>80</lpage></element-citation></ref>
<ref id="b3-jkos-59-388"><label>3)</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Kline</surname><given-names>LB</given-names></name><name><surname>Foroozan</surname><given-names>R</given-names></name></person-group><article-title>Neuro-Ophthalmology Review Manual</article-title><edition>7th</edition><publisher-loc>Thorofare</publisher-loc><publisher-name>SLACK</publisher-name><year>2013</year><fpage>83</fpage><lpage>122</lpage></element-citation></ref>
<ref id="b4-jkos-59-388"><label>4)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hahn</surname><given-names>CD</given-names></name><name><surname>Nicolle</surname><given-names>DA</given-names></name><name><surname>Lownie</surname><given-names>SP</given-names></name><name><surname>Drake</surname><given-names>CG</given-names></name></person-group><article-title>Giant cavernous carotid aneurysms: clinical presentation in fifty-seven cases</article-title><source>J Neuroophthalmol</source><year>2000</year><volume>20</volume><fpage>253</fpage><lpage>8</lpage></element-citation></ref>
<ref id="b5-jkos-59-388"><label>5)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mangat</surname><given-names>SS</given-names></name><name><surname>Nayak</surname><given-names>H</given-names></name><name><surname>Chandna</surname><given-names>A</given-names></name></person-group><article-title>Horner&#x0027;s syndrome and sixth nerve paresis secondary to a petrous internal carotid artery aneurysm</article-title><source>Semin Ophthalmol</source><year>2011</year><volume>26</volume><fpage>23</fpage><lpage>4</lpage></element-citation></ref>
<ref id="b6-jkos-59-388"><label>6)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Oh</surname><given-names>MJ</given-names></name><name><surname>Shin</surname><given-names>DS</given-names></name><name><surname>Se</surname><given-names>R</given-names></name><name><surname>Kim</surname><given-names>BT</given-names></name></person-group><article-title>Serpentine cavernous aneurysm presented with visual symptoms improved by endovascular coil trapping</article-title><source>J Cerebrovasc Endovasc Neurosurg</source><year>2016</year><volume>18</volume><fpage>379</fpage><lpage>84</lpage></element-citation></ref>
<ref id="b7-jkos-59-388"><label>7)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Park</surname><given-names>JY</given-names></name><name><surname>Koo</surname><given-names>NK</given-names></name></person-group><article-title>A giant unruptured aneurysm of distal internal carotid artery presenting with compressice optic neuropathy</article-title><source>J Korean Ophthalmol Soc</source><year>2012</year><volume>53</volume><fpage>1368</fpage><lpage>71</lpage></element-citation></ref>
<ref id="b8-jkos-59-388"><label>8)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stiebel-Kalish</surname><given-names>H</given-names></name><name><surname>Kalish</surname><given-names>Y</given-names></name><name><surname>Bar-On</surname><given-names>RH</given-names></name><etal/></person-group><article-title>Presentation, natural history, and management of carotid cavernous aneurysms</article-title><source>Neurosurgery</source><year>2005</year><volume>57</volume><fpage>850</fpage><lpage>7</lpage><comment>discussion 850-7</comment></element-citation></ref>
<ref id="b9-jkos-59-388"><label>9)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Penchet</surname><given-names>G</given-names></name><name><surname>Mourier</surname><given-names>K</given-names></name></person-group><article-title>Collaborative retrospective multicentre series of giant intracavernous carotid aneurysms</article-title><source>Neurochirurgie</source><year>2015</year><volume>61</volume><fpage>366</fpage><lpage>70</lpage></element-citation></ref>
<ref id="b10-jkos-59-388"><label>10)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Markwalder</surname><given-names>TM</given-names></name><name><surname>Meienberg</surname><given-names>O</given-names></name></person-group><article-title>Acute painful cavernous sinus syndrome in unruptured intracavernous aneurysms of the internal carotid artery. Possible pathogenetic mechanisms</article-title><source>J Clin Neuroophthalmol</source><year>1983</year><volume>3</volume><fpage>31</fpage><lpage>5</lpage></element-citation></ref>
<ref id="b11-jkos-59-388"><label>11)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nguyen</surname><given-names>DQ</given-names></name><name><surname>Perera</surname><given-names>L</given-names></name><name><surname>Kyle</surname><given-names>G</given-names></name></person-group><article-title>Recurrent isolated sixth nerve palsy secondary to an intracavernous carotid artery aneurysm</article-title><source>Eye (Lond)</source><year>2006</year><volume>20</volume><fpage>1416</fpage><lpage>7</lpage></element-citation></ref>
<ref id="b12-jkos-59-388"><label>12)</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Biousse</surname><given-names>V</given-names></name><name><surname>Newman</surname><given-names>NJ</given-names></name></person-group><article-title>Neuro-Ophthalmology Illustrated</article-title><edition>2nd</edition><publisher-loc>New York</publisher-loc><publisher-name>Thieme</publisher-name><year>2016</year><fpage>321</fpage><lpage>465</lpage></element-citation></ref>
<ref id="b13-jkos-59-388"><label>13)</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Pane</surname><given-names>A</given-names></name><name><surname>Miller</surname><given-names>NR</given-names></name><name><surname>Burdon</surname><given-names>M</given-names></name></person-group><article-title>The Neuro-Ophthalmology Survival Guide</article-title><edition>2nd</edition><publisher-loc>China</publisher-loc><publisher-name>Elsevier</publisher-name><year>2017</year><fpage>169</fpage><lpage>239</lpage></element-citation></ref>
<ref id="b14-jkos-59-388"><label>14)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Patel</surname><given-names>BM</given-names></name><name><surname>Ahmed</surname><given-names>A</given-names></name><name><surname>Niemann</surname><given-names>D</given-names></name></person-group><article-title>Endovascular treatment of supraclinoid internal carotid artery aneurysms</article-title><source>Neurosurg Clin N Am</source><year>2014</year><volume>25</volume><fpage>425</fpage><lpage>35</lpage></element-citation></ref>
<ref id="b15-jkos-59-388"><label>15)</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van Rooij</surname><given-names>WJ</given-names></name><name><surname>Sluzewski</surname><given-names>M</given-names></name></person-group><article-title>Unruptured large and giant carotid artery aneurysms presenting with cranial nerve palsy: comparison of clinical recovery after selective aneurysm coiling and therapeutic carotid artery occlusion</article-title><source>AJNR Am J Neuroradiol</source><year>2008</year><volume>29</volume><fpage>997</fpage><lpage>1002</lpage></element-citation></ref>
</ref-list>
<sec sec-type="display-objects">
<title>Figures</title>
<fig id="f1-jkos-59-388" position="anchor">
<label>Figure 1.</label>
<caption xml:lang="en"><p>Images of the patient in nine diagnostic position of gaze at initial visit. The patient showed esotropia at primary gaze with abduction limitation of the left eye.</p></caption>
<graphic xlink:href="jkos-59-388f1.tif"/>
</fig>
<fig id="f2-jkos-59-388" position="anchor">
<label>Figure 2.</label>
<caption xml:lang="en"><p>Images of cerebral digital subtraction angiography (DSA) during treatment. (A) Cerebral DSA showed ophthalmic segment aneurysm of left internal carotid artery (neck: 2.80 mm, height: 3.33 mm, width: 3.31 mm, posterior-inferior direction). (B) Cerebral DSA showed two microcatheters were located in the aneurysm. (C, D) Cerebral DSA showed coil embolization was finished with no abnormal findings.</p></caption>
<graphic xlink:href="jkos-59-388f2.tif"/>
</fig>
<fig id="f3-jkos-59-388" position="anchor">
<label>Figure 3.</label>
<caption xml:lang="en"><p>Images of the patient in nine diagnostic position of gaze at 3 months after the treatment. The patient showed stable ocular alignment without diplopia.</p></caption>
<graphic xlink:href="jkos-59-388f3.tif"/>
</fig>
</sec>
</back>
</article>