JKOS Journal of the Korean Ophthalmological Society J Korean Ophthalmol Soc 0378-6471 2092-9374 Korean Ophthalmological Society 10.3341/jkos.2017.58.1.93 jkos-58-93 Original Article A Case of Retinal Hemorrhage Following a Dexamethasone Intravitreal Implant KimMin Hwan MD, LeeYoung Hoon M.D Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea Address reprint requests to Young Hoon Lee, MD Department of Ophthalmology, Konyang University Hospital, #158 Gwanjeodong-ro, Seo-gu, Daejeon 35365, Korea Tel: 82-42-600-9258, Fax: 82-42-600-9251 E-mail: astrix001@gmail.com 08 2015 30 8 2015 58 1 93 97 11 8 2016 10 10 2016 23 12 2016 Copyright © 2015 Korean Ophthalmological Society 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Purpose

To report a case of retinal hemorrhage after a dexamethasone (Ozurdex®, Allergan, Irvine, CA, USA) intravitreal im-plant injection in macular edema (ME) secondary to central retinal vein occlusion (CRVO).

 Case summary

A 60-year-old woman visited our hospital for ME secondary to CRVO in the right eye. Intravitreal bevacizumab injection and vitrectomy was conducted three times, but ME did not improve. Then, dexamethasone intravitreal implant was in-jected without any problems. Right after the dexamethasone intravitreal implant injection, retinal hemorrhage (2 disc diopter size) was observed in the infero-temporal area on fundus examination. Retinal hemorrhage completely disappeared 1 month af-ter injection without other treatment.

 Conclusions

A case of dexamethasone intravitreal implant associated with retinal hemorrhage has not been previously reported in Korea. Althrough retinal hemorrhage was observed, it resolved spontaneously without treatment.

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Patient’s fundus photograph, optical coherence to-mography and fluorescein angiography at initial presentation. Fundus photograph (A) revealed retinal hemorrhage. Optical co-herence tomography (B) show severe macular edema. Fluorescein angiography (C) show central retinal vein occlusion.

Patient’s fundus photograph and optical coherence tomography after intravitreal bevacizumab injection twice and vitrectomy. Fundus photograph (A), optical coherence tomography (B) show the macular edema did not improved.

Patient’s fundus before and after dexamethasone intravitreal implant injection. (A) Before the injection show no retinal hemorrhage on inferotemporal fundus area. (B) Right after the injection show retinal hemorrhage (arrowheads) on inferotemporal fundus area. (C) Three days after injection shows the retinal hemorrhage (arrows) almost disappeared. (D) One month after injection show the retinal hemorrhage complete disappeared.