Korean J Gastroenterol KJG The Korean Journal of Gastroenterology 1598-9992 2233-6869 The Korean Society of Gastroenterology 10.4166/kjg.2012.59.5.338 Original Article Alimentary Tract Clinical Characteristics of Patients Diagnosed as Peptic Ulcer Disease in the Third Referral Center in 2007 Kim Jin Joo 1 Kim Nayoung 1 2 Park Hyun Kyung 2 Jo Hyun Jin 2 Shin Cheol Min 2 Lee Sang Hyup 1 2 Park Young Soo 1 2 Hwang Jin-Hyeok 1 2 Kim Jin-Wook 1 2 Jeong Sook-Hyang 1 2 Lee Dong Ho 1 2 Kim Jung Mogg 3 Lee Ji Hyun 4 Jung Hyun Chae 1 Song In Sung 1 Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. Department of Microbiology, Hanyang University School of Medicine, Seoul, Korea. Digestive Endoscopic Center, Seoul Song Do Colorectal Hospital, Seoul, Korea. Correspondence to: Nayoung Kim, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro 173-gil, Bundang-gu, Seongnam 463-707, Korea. Tel: +82-31-787-7008, Fax: +82-31-787-4051, nayoungkim49@empal.com 05 2012 21 05 2012 59 5 338 346 14 04 2011 14 06 2011 16 06 2011 Copyright © 2012 The Korean Society of Gastroenterology 2012

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 Background/Aims

In spite of the improvement of medical treatment for the peptic ulcer disease (PUD), PUD is still one of the common upper gastrointestinal diseases. The purpose of this study was to evaluate the risk factors and general characteristics of Korean patients diagnosed as PUD at a single third referral center.

 Methods

A total of 310 patients, diagnosed as PUD through endoscopy during one year of 2007 at Seoul National University Bundang Hospital were, retrospectively, evaluated regarding age, gender, Helicobacter pylori (H. pylori) positivity, clinical manifestations, comorbidities and medications. In addition, PUD was analyzed in the aspect of ulcer location, type of visit, gastrointestinal bleeding, and age.

 Results

The mean age was 61.5 years old (48.1% over 65) and 208 (66.7%) patients were men. The rate of H. pylori infection was 47.8%, and any ulcerogenic medication history such as antiplatelet agents and NSAIDs was found to be 21.0% (65 patients). The rate of idiopathic peptic ulcer without evidence of H. pylori and NSAIDs was found to be 40.6% (126 patients). Among 310 PUD patients, bleeding symptoms such as melena, hematemesis and hematochezia occurred in 110 patients (35.5%).

 Conclusions

PUD was more prevalent in the elderly patients and frequently associated with bleeding. Substantial proportion of PUD patients had neither H. pylori infection nor history of ulcerogenic medications, suggesting of increasing prevalence of idiopathic PUD.

 Peptic ulcer Risk factors Helicobacter pylori Nonsteroidal anti-inflammatory drugs Bleeding

Financial support: This work was supported by a grant from Korean Health Insurance Review and Assessment Service Fund in 2008.

Conflict of interest: None.

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Characteristics of Patients Who Are Diagnosed as Peptic Ulcer Disease

Values are presented as mean±SD or n (%).

H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Comparisons of the Clinical Characteristics according to the Location of Peptic Ulcer Disease

Values are presented as mean±SD or n (%).

H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Comparisons of the Clinical Characteristics according to the Type of Visit

Values are presented as mean±SD or n (%).

H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Comparisons of the Clinical Characteristics according to the Clinical Symptoms Suggestive of UGI Bleeding

Values are presented as mean±SD or n (%).

UGI, upper gastrointestinal; H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Comparisons of the Clinical Characteristics according to Age

Values are presented as n (%).

H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Relationship between H. pylori Positivity and Ulcerogenic Drugs

Values are presented as n (%).

H. pylori, Helicobacter pylori.

aUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Comparisons of the Clinical Characteristics according to the Etiology of Peptic Ulcer

Values are presented as mean±SD or n (%).

H. pylori, Helicobacter pylori.

aUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.