jkra The Journal of the Korean Rheumatism Association J Korean Rheum Assoc 1226-8070 2233-4718 The Korean Rheumatism Association 10.4078/jkra.2009.16.4.323 jkra-16-323 Original Article Dermatomyositis with Diffuse Large B Cell Lymphoma JangEun Jung 1 KimHyoun Ah 1 SungJun Mo 1 LeeJin Woo 1 HwangEui Kyung 1 KimHugh Chul 2 HanJae Ho 3 SuhChang Hee 1 Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea Department of Pathology, Ajou University School of Medicine, Suwon, Korea 01 2009 20 01 2009 16 4 323 327 15072009 02092009 02092009 Copyright © 2009 The Korean Rheumatism Association 2009 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract

Dermatomyositis (DM) is a rare and idiopathic inflammatory myopathy with characteristic cutaneous manifestations. There is a well-recognized association between DM and cancers. In Korea, several DM cases have been reported to be associated with stomach cancer, breast cancer, acute lymphoblastic leukemia, lung cancer, and tonsil cancer. However, an association between DM and lymphoma in Korea has not been reported up to now. We report a case of DM who developed diffuse large B-cell lymphoma 1 year and 8 months later.

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Cervical lymph node biopsy. (A) Extensive replacement of normal architecture by neoplastic centrocytes and centroblasts (H&E stain, ×100), (B) Centroblastic lymphoma shows neoplastic cells that are much larger than lymphocytes (H&E stain, ×400), (C) The tumor cells are positive for CD20 stain (Immunohistochemical stain with anti-CD20 antibody, ×400)

Positron emission tomography. (A) Probably multiple malignant lesions on subcutaneous nodules, abdominal lymph nodes (LNs), both axillary LNs and inguinal LNs and bone involvements on T5 and C5 were shown. (B) There was no significant abnormal FDG uptake to suggest malignancy. Benign reactive LNs uptake in right lower paratracheal and both hilar space was shown.