Tuberc Respir Dis TRD Tuberculosis and Respiratory Diseases 1738-3536 2005-6184 The Korean Academy of Tuberculosis and Respiratory Diseases 10.4046/trd.2009.67.2.131 Case Report A Case of Growing Endobronchial Glandular Papilloma Choi Byung Jin M.D. 1 Hwang Jin Won M.D. 1 Jung Jae Hyun M.D. 1 Lee Seung Heon M.D. 1 Lee Young Min M.D. 1 Jung Soo Jin M.D. 2 Song Jong Woon M.D. 3 Kim Hyun Dong M.D. 4 Lee Hyun-Kyung M.D. 1 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Pusan Paik Hospital, Inje University School of Medicine, Busan, Korea. Department of Pathology, Pusan Paik Hospital, Inje University School of Medicine, Busan, Korea. Department of Radiology, Pusan Paik Hospital, Inje University School of Medicine, Busan, Korea. Department of Rehabilitation, Pusan Paik Hospital, Inje University School of Medicine, Busan, Korea. Address for correspondence: Hyun-Kyung Lee, M.D. Department of Internal Medicine, Pusan Paik Hospital, Inje University School of Medicine, 633-165, Gaegum-2-dong, Jin-gu, Busan 614-735, Korea. Phone: 82-51-890-6270, Fax: 82-51-892-0273, goodoc@gmail.com 08 2009 31 08 2009 67 2 131 134 12 06 2009 14 07 2009 Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. 2009

Pulmonary papillomas are rare benign epithelial neoplasms arising in bronchial surface epithelium. They are categorized by a variety of cell types including squamous, glandular, and mixed squamous and glandular type. Among them, glandular papilloma is extremely rare and has not been reported in Korea. The patient was a 52 year-old man presenting with a 4-months' history of recurrent hemoptysis. Bronchofiberoscopy revealed a whitish, glistening, and polypoid mass lesion at the proximal bronchus in the basal segment of the left lower lung. Bronchoscopic biopsy was performed; papillary fronds lined by ciliated or nonciliated pseudostratified columnar epithelium were noted on histologic findings. We present the first case of glandular papilloma in Korea. Two years later, the patient visited our hospital again due to hemoptysis. On follow-up bronchoscopy, a mass that had been found previously showed an increase in size.

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(A) Supine anteriorposterior chest radiograph shows mild volume loss and patch consolidation in the left lower lobe. (B) Axial CT scan show endobronchial mass (arrow) in the proximal portion of left lower basal segmental bronchus and atelectasis in the medial and anterior basal segment of left lower lobe.

(A) Initial bronchoscopy shows a glistening, polypoid and lobulating mass lesion that partially obstructing the orifice of left lower lobe basal segment. (B) Follow up bronchoscopy shows a increased mass lesion that completely occluding the lumen of left lower lobe bronchus.

Endobrochial biopsied tissue reveals papillary fronds lined by pseudostratified nonciliated or focally ciliated columnar cells showing piliform cellular tufting (H&E stain, ×100).

(A, B) Follow up supine anteriorposterior chest radiograph and coronal CT scan after 2 years show more enlarged endobronchial mass (arrowhead) and progression of postobstructive atelectasis and consolidation in the basal segment of left lower lobe.