To investigate the effect of extracorporeal shock wave therapy (ESWT) on myofascial pain syndrome (MPS).
Thirty patients with MPS in trapezius muscle were randomly divided into two groups, ESWT group (n=15), and trigger point injections (TPI)+transcutaneous electrical nerve stimulation (TENS) group (n=15). For a total of 3 weeks, ESWT was undertaken with 1,500 pulse each time at one week interval totaling 4,500 pulse, TPI for once a week totaling three times and TENS for five times a week totaling three weeks.
The changes in pain threshold (lb/cm2) showed the values of 6.86±1.35 before first therapy, 11.43±0.27 after first therapy, and 12.57±0.72 after third therapy, while TPI+TENS group showed the values of 6.20±1.92 before first therapy, 8.80±0.48 after first therapy, and 9.60±2.19 after third therapy, and the changes between the groups were significantly different (p=0.045). The changes in visual analog scale were estimated to be 6.86±0.90 before first therapy, 2.86±0.90 after first therapy, and 1.86±0.69 after third therapy in case of ESWT group, whereas the figures were estimated to be 7.20±1.30 before first therapy, 4.60±0.55 after first therapy, and 2.80±0.84 after third therapy in case of TPI+TENS group, and the changes between the groups were significantly different (p=0.010). The changes in McGill pain questionnaire (p=0.816) and pain rating scale (p=0.644) between the groups were not significantly different. The changes in neck ROM were also not significantly different between the groups (p>0.05).
The ESWT in patients with MPS in trapezius muscle are as effective as TPI and TENS for the purpose of pain relief and improving cervical range of motion.
Myofascial pain syndrome is known to be a clinically common syndrome with characteristics including localized muscle tenderness, typical referred pain, palpable intramuscular taut band and muscular twitching response, etc., and induction of pain due to the myofascial trigger points (MTrPs) is defined as hyperirritable spot of taut band.
Myofascial pain syndrome is a problem frequently experienced in clinical setting that accounts for the largest proportion of the diseases of musculoskeletal system occurring in cervical and lumbar vertebral portion, and shoulder, and is a common cause that induces disability due to pain. The basic diagnostic method of myofascial pain syndrome is determined by physical examination such as localized muscle tenderness, typical referred pain, palpable intramuscular taut band, muscular twitching response along with subjective symptoms of the patients. In addition, method of assessment of pain threshold using algometry can be helpful in diagnosing myofascial pain syndrome. As the methods of treatment for myofascial pain syndrome, stretching, dry-needling and trigger point injection using diverse range of drugs are used along with generally practiced physical therapy.
Recently, application of Extracorporeal Shock Wave Therapy (ESWT) has been expanded as one of the treatment methods for the diseases of musculoskeletal system. Although there have been reports about the effectiveness of ESWT mainly on epicondylitis, plantar fasciitis, chronic pelvic pain, chronic painful heel syndrome, lymphedema, burn wound, pressure ulcer and calcific tendinitis, its effectiveness on treatment of myofascial pain syndrome has not been reported. Accordingly, this study aims to examine the effectiveness and clinical usefulness of ESWT by comparing the ESWT implemented group with the trigger point injection (TPI) and transcutaneous electrical nerve stimulation (TENS) implemented group with myofascial pain syndrome patients as the subjects.
The authors selected 30 patients who were diagnosed with myofascial pain syndrome in the trapezius muscle as a result of physical examination with pain in the posterior neck and shoulder areas as the chief complaint among the hospitalized patients at our hospital from January to December 2011 as the subjects of this study. This study is a prospective randomized experimental and control group research with the subjects divided into 2 groups, namely, the experimental group with 15 subjects who underwent ESWT, and the control group with 15 subjects who underwent TPI and TENS. For ESWT treatment, subjects were given total of 1,500 shock waves for each treatment at the rate of 240 waves, each with low energy flux density (EFD) of 0.10 mJ/mm2 per minute by using EvoTron RFL0300 of SwiTech Medical AG 3 times with a week's interval between the treatments (total of 4,500 shock waves). Treatment was given by focusing on the area at which muscular twitching response or referred pain should be induced by appropriately adjusting the location of the localized probe. Total of 3 TPI treatments with a week's interval between the treatment and total of 5 TENS treatments were given 5 times in a week with a duration of 20 minutes a day. Both the groups underwent treatment for total of 3 weeks each. Visual Analogue Scale (VAS), McGill pain questionnaire, Pain Rating Scale (PRS), neck range of motion (curvature, extension, rotation, lateral bending) and BASELINE® (Hoggan Health Industries Inc., West Jordan, USA) were used to confirm the changes in the pain threshold level (lb/cm2) prior to the first treatment (preliminary assessment), 1 week after the first treatment (interim assessment) and 1 week after the third treatment (final assessment) as the assessment method for assessing the effectiveness of treatment. At the time of final assessment, the results were categorized on the basis of assessment of Roles and Maudsley score and whether MTrPs was induced and referred pain was extinct, 'Excellent' if both have been extinct, 'Good' if only one of the 2 has been extinct and 'Poor' if both have not been extinct for additional execution of final response assessment.
Collected data were analyzed by using SPSS 19.0 program (SPSS Inc., Chicago, USA). Fisher's Exact test and Mann-Whitney test were carried out for homogeneity test on the 2 groups. Since the result of review of the normality assumption on the preliminary assessment tools of the 2 groups was satisfactory, Independent Samples t-Test was carried out to verify the preliminary homogeneity, and Repeated Measure ANOVA was carried out for examination of the effectiveness of the results of preliminary assessment, and assessment following the 1st and the 3rd treatment. Prior to execution of Repeated Measure ANOVA, Sphericity test of Mauchly for measurement of homoscedasticity and compound symmetry was performed. In the case of satisfaction of the sphericity assumption (p>0.05), verification of time effect (Time) and reciprocal action effect (Group×Time) were analyzed by using sphericity assumption statistics of Univariate test. If sphericity assumption was not satisfied (p<0.05), statistics of Wilks' Lambda in Multivariate test was used. Moreover, Fisher's exact test of small specimen was carried out for verification of the results of Roles and Maudsley score and final response assessment. Lastly, in order to find out if there are differences in the results of treatment between the 2 groups due to gender difference, gender difference was confirmed by using Independent Samples t-Test in the final assessment.
A total of 30 patients comprised 22 males and 8 females. Of the 15 subjects in the experimental group, 13 were male and 2 were female, while the control group composed of 9 males and 6 females. The average age was 40.86±13.07 years for the experimental group and 45.00±15.46 years for the control group. As a result of the physical examination, taut band and referred pain were observed in both, the experimental and the control group. Localized twitching response was observed in all the 15 subjects of experimental group while 12 of the 15 subjects of the control group displayed the response. As a result of Fisher's Exact test and Mann-Whitney test carried out to examine the preliminary homogeneity between the 2 groups, both the groups were found to be homogeneous as there was no significant difference (p>0.05) (
As a result of Repeated Measure ANOVA on pain threshold, it was found that there was significant difference in accordance with groups (p=0.045<0.05), time effect (p<0.001) and reciprocal action effect (p=0.001<0.01). As a result of contrast test on time, a significant difference was observed prior to commencement, following the 1st and the 3rd treatment, illustrating that the pain threshold began to increase after the 1st treatment. Effect of the group was found to be significant, resulting in higher pain threshold in the ESWT group in comparison to the TPI and TENS group. As a result of contrast test on the reciprocal action, there was significant difference prior to commencement, following the 1st and the 3rd treatment, illustrating that the treatment effect in the ESWT group was greater than the TPI and TENS group since the 1st treatment (
As a result of sphericity on VAS, it was found that sphericity assumption was satisfied (p=0.071>0.05), and it was also found that although there was significant difference in VAS in accordance with groups (p=0.010<0.05) and time effect (p<0.001), there was no reciprocal action effect (p=0.162>0.05). As a result of contrast test on time, there was significant difference in VAS prior to commencement, following the 1st and the 3rd treatment. Therefore, a significant reduction in VAS was noted following the treatment. Although there was significant difference in VAS between the groups, it was found that there was no reciprocal action effect. This signifies that treatment using ESWT is more effective than the treatment using TPI and TENS since the VAS of the ESWT group was found to be lower than that of the TPI and TENS group (
Sphericity assumption was satisfied as a result of Repeated Measure ANOVA on McGillpain questionnaire (p=0.666>0.05). Although there was no significant difference between the groups (p=0.816>0.05), time effect (p<0.001) and reciprocal action effect (p=0.031<0.05) was observed. As a result of contrast test on time, it was found that there was reduction following the 1st and the 3rd treatment in comparison to prior to commencement, thus illustrating that McGill pain questionnaire was significantly reduced as the treatment was carried out. There was significant difference in the results of contrast test on reciprocal action prior to commencement and following the 3rd treatment. This signifies that although the McGill pain questionnaire prior to commencement was found to be higher in the ESWT group, it was lower in the ESWT group following the 3rd treatment and that treatment using ESWT had greater effectiveness after the 3rd treatment (
Sphericity assumption was found to be unsatisfactory based on the result of sphericity on PRS (p<0.001). Based on the Repeated Measure ANOVA carried out by Wilks' Lambda, it was found that there was no significant difference between the groups (p=0.644>0.05) but also no reciprocal action effect (p=0.806>0.05), and only the time (p=0.004<0.01) effect was found to be significant. As a result of contrast test on time, significant difference prior to commencement and following the 1st and the 3rd treatment was observed, illustrating that PRS was reduced significantly since the 1st treatment (
As a result of the Repeated Measure ANOVA carried out on neck range of motion, there was no significant difference between the groups (p>0.05) but also no reciprocal action effect (p>0.05) in all the category, and, in all the categories excluding extension, time (p<0.05) effect was found to be significant. Therefore, it was found that there was effectiveness of treatment on both the ESWT group and TPI and TENS group in terms of neck range of motion (
As a result of measurement of Roles and Maudsley score, experimental group had 6 subjects with rating of excellent and 9 subject with rating of good among total of 15 subjects while control group had 3 subjects with rating of excellent, 9 subjects with rating of good and 3 subjects with rating of acceptable among the total of 15 subjects. There was no significant difference between the groups (p=0.233>0.05).
As a result of measurement in the final response assessment, experimental group had 10 subjects with rating of excellent and 5 subjects with rating of good among total of 15 subjects while control group had 6 subjects with rating of excellent and 9 subjects with rating of good among total of 15 subjects. There was no significant difference between the groups (p=0.272>0.05).
As a result of confirmation of the differences between the gender in the final assessment in order to determine the differences in the results of treatment in the 2 groups due to gender ratio, no significant gender difference (p>0.05) was observed (
The ESWT was first applied in Germany in 1996 and following 5 diseases to which ESWT can be applied clinically were proposed: (1) calcific tendonitis, (2) lateral epicondylitis, (3) medial epicondylitis, (4) plantar fasciitis, and (5) pseudoarthrosis.
The ESWT equipment currently used in clinical setting is divided into radial and focused methods in accordance with the manner in which the shock wave reaches the target. There are 3 methods of generating focused-type shock wave, namely, piezoelectric, electromagnetic and electrohydraulic methods. Shock wave is generated by using the principle in which electricity is converted into shock wave through quick physical movement of electricity in a liquid medium. Each of the equipment uses charged condenser with different voltage from each other, and conversion into shock wave is achieved as electricity becomes rapidly discharged in acoustic transducer.
Until now, there is no guideline that clearly defines the number of and interval for execution of ESWT. In the study by Jung et al.,
In general, it is known that the effect of extracorporeal shock wave in living tissues induces characteristic changes within the cells due to conversion of the mechanical signal into biochemical or molecular biologic signal (Mechanotransduction).
In a study by Muller-Ehrenberg and Licht,
In this study, when the mechanisms through which the ESWT was effective on myofascial pain syndrome are considered, abnormal shortening of muscle occurs due to increase in excessive discharge of acetylcholine into the neuromuscular junction as one of the factor of causing myofascial trigger points. This does not occur in all the muscle fibers but rather only in some of the sarcomere histologically. Such an abnormal shortening induces the localized ischemia and increases the metabolism of the shortened areas, and causes energy crisis. Various pain inducing substances (prostaglandin, bradykinin, substance P, CGRP, K+, serotonin and histamine, etc.) are secreted due to energy crisis, which eventually induces localized pain by supersensitization of nociceptors of muscles.
In order to diagnose myofascial pain syndrome, detailed past history, diagnostic findings through physical examination and confirmative findings are necessary. As a confirmative finding, localized twitching response and typical referred pain need to be confirmed at the time of application of needle or pressurization. In this study, it was possible to confirm that localized muscular twitching reaction and typical referred pain were induced when shock wave was applied on accurate location in the group that underwent ESWT.
At present, diagnosis of myofascial pain syndrome is made on the basis of findings of physical examination as there is no available laboratory test or examination tool that is generally established for confirmed diagnosis. Measurement of pain threshold on the pressure by using algometry at the areas that correspond to the point of induction of pain can be helpful in diagnosis as the extent of pain can be expressed with respect to objective value.
Limitations of this study include the point that treatment has been standardized due to lack of definitive guidelines on the intensity, interval and frequency of the stimulation for ESWT for diseases of musculoskeletal system and the most important limitation is that explanations on the principles and mechanisms of the effectiveness of ESWT are provided on the basis of hypothesis and inferences based on the past researches. Therefore, it is deemed that additional cytohistological and molecular biologic researches are needed in the future.
In this study, it was found that ESWT is as effective in causing reduction in pain and improvement in neck range of motion as TPI and TENS in patients with myofascial pain syndrome in trapezius muscle. In addition, execution of ESWT is deemed to be helpful in diagnosing myofascial pain syndrome as it would enable confirmation of occurrence of referred pain and muscular twitching response, which are the standards for the diagnosis of myofascial pain syndrome.
The ESWT is one of the novel treatment methods with its wide range of clinical application, which are gradually expanding for the purpose of treatment of diseases of musculoskeletal system. It is being applied to diverse range of areas due to the usefulness in clinical application since it is non-invasive, can be repeated and carried out in a relative safer manner. However, researches on its mechanism are still inadequate and standardized treatment guideline is yet to be established in order to produce the optimal results. Therefore, continuous efforts to establish the most effective treatment guidelines are needed in the future, and, if relationship between the mechanism and therapeutic adaptability can be investigated more clearly and definitively, it is expected to play more important role in the area of rehabilitative therapy.
Demographic and Clinical Characteristics of Patients
ESWT: Extracorporeal shock wave therapy
*Fisher's Exact test, †Mann-Whitney test, values are mean±standard deviation
Pre-homogeneity Test of Preliminary Assessment
Independent Samples t-Test, Values are mean±standard deviation
ESWT: Extracorporeal shock wave therapy
The Change in Pain Threshold and Visual Analog Scale
Values are mean±standard deviation
ESWT: Extracorporeal shock wave therapy
The Change in McGill Pain Questionnaire and Pain Rating Scale
Values are mean±standard deviation
ESWT: Extracorporeal shock wave therapy
The Change in Neck Range of Motion
Values are mean±standard deviation
ESWT: Extracorporeal shock wave therapy
Independent Samples t-Test of Final Assessment between Male and Female Subjects
Values are mean±standard deviation