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Increased cardiovascular events, which is the leading cause of death in type 2 diabetic patients, are mainly caused by accelerated atherosclerosis. Adiponectin has been suggested as a risk factor for cardiovascular diseases in cross-sectional studies. However, little is known about the impact of adiponectin on the progression of carotid atherosclerosis in type 2 diabetic patients. This study was conducted to evaluate the impact of early adiponectin levels on the progression of carotid atherosclerosis.
From March 2009, 150 patients with type 2 diabetes were consecutively enrolled in our affiliated outpatient clinic. Anthropometric and biochemical data, including adiponectin levels, were measured in each participant. We measured the carotid intima-media thickness (CIMT) at baseline and at 1-year follow-up (n = 111). Then, we prospectively studied the relationship between the serum adiponectin levels and the progression of CIMT for 1 year.
Adiponectin levels negatively correlated with CIMT (r = -0.219,
In our study, adiponectin levels were negatively associated with CIMT. However, it did not affect the progression of CIMT at 1-year follow-up. Overall glycemic control is the most important factor in the progression of CIMT in patients with type 2 diabetes.
Correlation between serum adiponectin concentration (log transformed) and baseline carotid artery intima-media thickness (CIMT). (r = -0.219,
Correlation between serum adiponectin concentration (log transformed) and progression of carotid artery intima-media thickness (CIMT) (r = -0.156,
Clinical and biochemical characteristics of the subjects according to progression of carotid intima-media thickness
Values are expressed as mean ± SD.
CIMT, carotid intima-media thickness; DPP4, dipeptidyl peptidase-4; HDL, high density lipoprotein; HOMA-IR, homeostatic model assessment for insulin resistance; LDL, low-density lipoprotein; Ln, lymph node; RAS, renin angiotensin system.
Differences in medication use in 1 year
Values are expressed as %.
DPP4, dipeptidyl peptidase- 4; RAS, renin angiotensin system.
Multivariate logistic regression modeling for predictors of carotid artery intima-media thickness in type 2 diabetic patients
BMI, body mass index; HDL-C, high density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment for insulin resistance; LDL-C, low density lipoprotein cholesterol; Ln, lymph node.
Multivariate logistic regression modeling for predictors of progression of carotid artery intima-media thickness in type 2 diabetic patients
BMI, body mass index; CIMT, carotid artery intima-media thickness; HDL-C, high density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment for insulin resistance; LDL-C, low density lipoprotein cholesterol; Ln, lymph node.