Current Understanding of Dendritic Cells in Atherosclerosis

Jae-Hoon Choi

doi:10.7599/hmr.2013.33.1.52

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Choi: Current Understanding of Dendritic Cells in Atherosclerosis

Review Article

Hanyang Medical Reviews

Hanyang Medical Reviews 2013; 33(1): 52-58.

Published online: 27 February 2013

DOI: https://doi.org/10.7599/hmr.2013.33.1.52

Current Understanding of Dendritic Cells in Atherosclerosis

Jae-Hoon Choi

Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea.

Correspondence to: Jae-Hoon Choi. 516-ho, Department of Life Science, College of Natural Sciences, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea. Tel: +82-2-2220-2540, Fax: +82-2-2299-3495, jchoi75@hanyang.ac.kr

Received 26 November 2012 Revised 4 January 2013 Accepted 12 January 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dendritic cells (DCs), first identified in 1973, have been shown to be the principal cells involved in antigen presentation to T cells, and are more potent in the presentation of antigen than B cells or macrophages. Atherosclerosis is a representative chronic vascular inflammatory disease in which various immune cells have been implicated in the formation of atherosclerotic plaque. Thus, the quantification and elucidation of activity of immune populations in atherosclerotic vessels are very important in understanding the pathogenesis of atherosclerosis. Several current studies demonstrate that DCs which exist in atherosclerotic lesion appear to play several important roles in atherosclerosis. This review summarizes current understandings on the function of DCs in atherosclerosis, and also suggests future directions for research of DC function in inflammatory atherosclerotic vascular disease.

Keywords: Dendritic Cells, Blood Vessels, Inflammation, Atherosclerosis

Figures and Tables

Fig. 1

Distribution of dendritic cells in normal mouse aorta. Left panels show immunofluorescence staining of CD11c in normal aorta. The aorta was perfused with ice-cold 4% paraformaldehyde in PBS via the left ventricle. After removing perivascular tissues, the segments of aortic sinus, aortic arch and thoracic aorta were opened longitudinally and further fixed in 4% paraformaldehyde at 4℃ for 30 min. After permeabilization using 0.2% triton X-100, staining for CD11c was performed using the Tyramide amplification (TSA) kit (Invitrogen) under the manufacturer's protocol. Right figure shows the relative density of intimal CD11c+ DCs in normal aorta. Reds indicate areas with numerous DCs.

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