Journal List > J Lung Cancer > v.11(2) > 1050648

An, Cho, Chung, and Ha: Comparison of ThinPrep Cytology and Conventional Cytology in Bronchial Washing for Lung Cancer

Abstract

Purpose

Liquid-based cytology have been developed and currently used to overcome the limitation of conventional cytology. This study aims to evaluate the differences between conventional cytology and ThinPrep® in the bronchial washing.

Materials and Methods

Both conventional cytology and ThinPrep® were performed in the 2,551 cases of bronchial washing, of which, 116 cases of histologically diagnosed as lung cancer were evaluated.

Results

Among the 116 cases, 23 and 4 cases were negative in conventional cytology and ThinPrep®, respectively. The thirty eight cases in conventional cytology and 30 cases in ThinPrep® were diagnosed as "atypical." Malignant carcinoma was 54 cases and 82 cases in conventional cytology and ThinPrep®, respectively. The positive predictive value, negative predictive value, sensitivity and specificity were 98.94%, 99.06%, 80.17%, and 99.96%, respectively in conventional cytology. Those were 99.12%, 99.83%, 96.55% and 99.96%, respectively in ThinPrep®.

Conclusion

ThinPrep® (liquid-based cytology) revealed higher sensitivity and lower false negative rate than conventional cytology. ThinPrep® has many advantages to diagnose the lung cancer from bronchial washing cytology.

Figures and Tables

Table 1
Comparison Cytological Cellularity between Cytospin and ThinPrep®
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Table 2
Histologic and Cytological Correlation
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LCNEC: large cell neuroendocrine carcinoma.

Table 3
Correlation of Histology and Conventional Cytology
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*Poorly differentiated carcinoma and large cell neuroendocrine carcinoma.

Table 4
Correlation of Histology and ThinPrep® Cytology
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*Poorly differentiated carcinoma and large cell neuroendocrine carcinoma.

Table 5
Comparative Analysis of ThinPrep® for Conventional Cytology Diagnosed as 'Atypical'
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Table 6
Comparative Analysis of Conventional Cytology for ThinPrep® Cytology Diagnosed as 'Atypical'
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