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Moon, Park, and Choi: Web Interface Generator of Ontology Based CRF for Clinical Trial in Western and Oriental Medicine
Original Article
Journal of Korean Society of Medical Informatics

Journal of Korean Society of Medical Informatics 2009; 15(1): 59-69.

Published online: 31 March 2009

DOI: https://doi.org/10.4258/jksmi.2009.15.1.59

Web Interface Generator of Ontology Based CRF for Clinical Trial in Western and Oriental Medicine

Jinseok Moon1, Kyungmo Park2, Sunmi Choi1

1Korea Institute of Oriental Medicine, Korea.

2Department of Biomedical Engineering, Kyunghee University, Korea.

Corresponding Author (moonstone2@kiom.re.kr)

Received 18 November 2008       Accepted 9 March 2009

Copyright © 2009 The Korean Society of Medical Informatics

Abstract

Objective

This study aims to develop the web-interface creator, which automatically changes the Case Report Form(CRF) web page when the protocol developer in any clinical study revises the ontology of CRF.

Methods

This study established the conceptual model of CRF on oriental and western medicine, and developed ontologies. A program was developed to produce online-based a input form through the parser that generates automatically HTML script from OWL.

Results

The CRF applied in this study is a draft through consensus of experts for stroke research at the Korea Institute of Oriental Medicine. The ontology of CRF consisted of Label, ControlType and Value classes and hasControl, hasValue and hasSymptoms properties. The Label is the class of question items groups, so it could have CRF questionnaire instances. The ControlType is the class that expresses controls such as checkbox, text, etc in the HTML script. The Value class represents selections for each items. Finally, the HTML script was created by XSL transformation from the OWL script.

Conclusion

Online-based automatic interface creation, which enables immediate coping with the continuous change in the medical knowledge system, assures reduced time requirement.

Keywords: Ontology, OWL, XSLT, Electronic Case Report Form, Clinical Research

Figures and Tables

Figure 1
Sequence diagram of e-CRF
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Figure 2
Process of programming
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Figure 3
Conceptual framework for patient findings-ISO/TC 215 DTS 22789
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Figure 4
Conceptual model of OntoCRF in cerebrovascular disease
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Figure 5
Classes(left) and properties(right)
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Figure 6
ControlType instance
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Figure 7
Instance Tab
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Figure 8
hasValue property
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Figure 9
hasUnit property
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Figure 10
Structured view of OntoCRF by OntoViz
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Figure 11
Relationship View using TGVizTab
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Figure 12
Queries tab to search instances
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Figure 13
XSL algorithms for transformation from OWL to HTML
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Figure 14
Output to HTML
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References

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