Hymenoptera venom anaphylaxis in adult Korean: a multicenter retrospective case study

Lee, Su-Kyoung; Ye, Young-Min; Park, Hae-Sim; Jang, Gwang Cheon; Jee, Young-Koo; Park, Hye-Kyung; Koh, Young-Il; Kim, Joo-Hee; Kim, Cheol-Woo; Hur, Gyu-Young; Kim, Mi Kyoung; Kim, Tae-Bum; Choi, Gil-Soon; Kim, Sang-Heon; Sohn, Seong-Wook; KAAACI Work Group for Urticaria/Angioedema/Anaphylaxis

doi:10.4168/aard.2014.2.5.344

Original Article

Open Access


Allergy Asthma Respir Dis. 2014 Nov;2(5):344-351. Korean. Published online November 28, 2014. https://doi.org/10.4168/aard.2014.2.5.344
© 2014 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology


Hymenoptera venom anaphylaxis in adult Korean: a multicenter retrospective case study
Su-Kyoung Lee,¹ Young-Min Ye,² Hae-Sim Park,² Gwang Cheon Jang,³ Young-Koo Jee,⁴ Hye-Kyung Park,⁵ Young-Il Koh,⁶ Joo-Hee Kim,⁷ Cheol-Woo Kim,⁸ Gyu-Young Hur,⁹ Mi Kyoung Kim,¹⁰ Tae-Bum Kim,¹¹ Gil-Soon Choi,¹² Sang-Heon Kim,¹³ Seong-Wook Sohn,¹ and KAAACI Work Group for Urticaria/Angioedema/Anaphylaxis
¹Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.
²Department of Internal Medicine, Ajou University School of Medicine, Suwon, Korea.
³Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
⁴Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
⁵Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
⁶Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
⁷Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
⁸Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.
⁹Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
¹⁰Department of Internal Medicine, Chungbuk National University, Cheongju, Korea.
¹¹Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
¹²Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
¹³Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Correspondence to: Seong-Wook Sohn. Department of Internal Medicine, Dongguk University Ilsan Hospital, 27 Dongguk-ro, Ilsandong-gu, Goyang 410-773, Korea. Tel: +82-31-961-7148, Fax: +82-31-961-8449, Email: seongwook@dumc.or.kr

Received January 28, 2014; Revised April 03, 2014; Accepted May 07, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).
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Go to: Abstract
Purpose We investigated the causes, clinical features, and risk factors of bee venom anaphylaxis in Korea. Methods The medical records of the diagnosis of anaphylaxis during a 5-year period from the 14 hospitals in Korea have been retrospectively reviewed. Cases of bee venom anaphylaxis were identified among anaphylaxis patients, and subgroup analyses were done. Results A total of 291 patients were included. The common cause of bee species was vespid (24.6%) in bee venom anaphylaxis, followed by honeybee and vespid (8.8%), apitherapy (7.7%), and honeybee (2.0%), although the causative bee species were commonly unknown (56.9%). The severity of anaphylaxis was mostly mild-moderate (72.9%), and common clinical manifestations included cutaneous (80.6%), cardiovascular (39.2%), respiratory (38.1%), and gastrointestinal (13.1%) symptoms. Portable epinephrine auto-injectors were prescribed to 12.1% of the patients. Subject positive to both vespid and honeybee showed more severe symptoms and higher epinephrine use (P<0.05). The severity was significantly associated with older age, but not with gender, underlying allergic disease, or family history. Apitherapy-induced anaphylaxis showed a higher rate of hospitalization and epinephrine use than bee sting anaphylaxis (P<0.05). Conclusion Vespid is the most common cause of bee venom anaphylaxis in Korea. It is suggested that positivity to honeybee and vespid may be associated with more severe symptoms.


Keywords: Hymenoptera; Bee venoms; Anaphylaxis; Apitherapy

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Tables


	Table 1 Clinical characteristics of subjects (n=291)
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	Table 2 Clinical manifestation of bee venom anaphylaxis
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	Table 3 Comparison of clinical parameters between the causes in bee venom anaphylaxis
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	Table 4 Comparison of clinical parameters between severe and mild-moderate bee venom anaphylaxis
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	Table 5 Comparison of clinical parameters between bee sting anaphylaxis and apitherapy
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