Journal List > Allergy Asthma Respir Dis > v.2(3) > 1059024

Park, Kim, Jung, Lee, Yang, Seo, Kwon, Kim, Kim, Lee, Song, Jang, Kim, Shim, and Hong: Predicted normal values of pulmonary function tests in normal Korean children

Abstract

Purpose

Pulmonary function tests are useful and important methods for evaluating patients with respiratory diseases. To assess lung function, we need to establish normal values of lung function, which vary according to population, age, gender and growth, particularly in children. This study was undertaken to establish normal predicted values of pulmonary function tests and to predict renewed reference values by spirometry in Korean school children.

Methods

Spirometric forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory flow at 25% to 75% of FVC (FEF25%-75%), and peak expiratory flow rate (PEFR) were measured in 406 healthy elementary school children (age, 6-12 years old) in May, 2012. Multiple linear regression analysis was performed for each spirometric parameter against age, height, weight and body surface area (BSA) separately for boys and girls, and derived reference equations and coefficients for all the spirometric parameters.

Results

All the measured spirometric parameters were significantly correlated with age, height, weight, and BSA. FVC was higher in boys aged 6-10 years than girls at ages matched. Height showed the highest correlation coefficient for all the spirometric parameters followed by BSA, weight and age in both genders. The normal predicted values of FVC and FEV1 at 130 cm in this study using renewed reference equations were approximately in the middle compared to previous studies.

Conclusion

We reported here the renewed reference equations for normal predicted values of pulmonary function tests with high coefficients of determination based on updated data in healthy Korean children.

Figures and Tables

Table 1
Characteristics of the study subjects
aard-2-187-i001

Values are presented as mean±standard deviation.

FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; FEF25%-75%, forced expiratory flow at 25% to 75% of FVC; PEFR, peak expiratory flow rate.

Table 2
Mean values of spirometric parameters
aard-2-187-i002

Values are presented as mean±standard deviation.

FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; FEF25%-75%, forced expiratory flow at 25% to 75% of FVC; PEFR, peak expiratory flow rate.

Table 3
Prediction equations and square of regression coefficients for each spirometric parameter
aard-2-187-i003

FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; FEF25%-75%, forced expiratory flow at 25% to 75% of FVC; PEFR, peak expiratory flow rate; r2, square of regression coefficient. A, age (yr); H, height (cm); W, weight (kg); B, body surface area (m2).

Table 4
Multiple linear regression equations for spirometric parameters with variables of the physical measurements in male subjects
aard-2-187-i004

r2, square of regression coefficient; SEE, standard error of the estimates; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; FEF25%-75%, forced expiratory flow at 25% to 75% of FVC; PEFR, peak expiratory flow rate; A, age (yr); H, height (cm); W, weight (kg); B, body surface area (m2).

Table 5
Multiple linear regression equations for spirometric parameters with variables of the physical measurements in female subjects
aard-2-187-i005

r2, square of regression coefficient; SEE, standard error of the estimates; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; FEF25%-75%, forced expiratory flow at 25% to 75% of FVC; PEFR, peak expiratory flow rate; A, age (yr); H, height (cm); W, weight (kg); B, body surface area (m2).

Table 6
Comparison of predicted values of FVC and FEV1 with previous studies
aard-2-187-i006

FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; H, height (cm).

Notes

This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare, Republic of Korea (A092076).

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