Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children

Young Hye Shin; Jong Ha Park; Myoung Soon Sung; Sung Won Kim

doi:10.4168/aard.2014.2.2.114

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Shin, Park, Sung, and Kim: Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children

Original Article

Allergy, Asthma & Respiratory Disease 2014; 2(2): 114-121.

Published online: 31 May 2014

DOI: https://doi.org/10.4168/aard.2014.2.2.114

Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children

Young Hye Shin, Jong Ha Park, Myoung Soon Sung, Sung Won Kim

Department of Pediatrics, Busan St. Mary's Hospital, Busan, Korea.

Correspondence to: Sung Won Kim. Department of Pediatrics, Busan St. Mary's Hospital, 25-14 Yongho-ro 232beon-gil, Nam-gu, Busan 608-838, Korea. Tel: +82-51-933-7981, Fax: +82-51-936-7531, sbdph1@daum.net

Received 15 July 2013 Revised 27 August 2013 Accepted 30 August 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

Vitamin D deficiency has been suggested to play a role in the pathogenesis of atopic dermatitis. In addition, inverse correlationship between serum 25-hydroxyvitamin D concentration and severity of atopic dermatitis has been suggested.

Methods

Clinical and laboratory parameters including serum 25-hydroxyvitamin D level and serum total IgE of 251 patients with atopic dermatitis who were 13 months to 18 years were measured. Severity of atopic dermatitis was assessed with SCORing Atopic Dermatitis (SCORAD) index. Statistical analysis was performed using Pearson correlation coefficient, one-way analysis of variance test and chi-square test.

Results

Among 251 patients, vitamin D deficiency (25-hydroxyvitamin D<20 ng/mL, group 1) was present in 76 subjects (30.3%), vitamin D insufficiency (25-hydroxyvitamin D 20-29 ng/mL, group 2) was present in 101 (40.2%), and vitamin D sufficiency (25-hydroxyvitamin D≥30 ng/mL, group 3) was present in 74 (29.5%). There was a statistically significant inverse correlation between serum concentration of 25-hydroxyvitamin D and values of SCORAD index (R=-0.24, P<0.000). Serum concentration of 25-hydroxyvitamin D were inversely correlated with total IgE (R=-0.29, P<0.000), and age (R=-0.49, P<0.000).

Conclusion

The results from this study indicate that serum concentration of 25-hydroxyvitamin D is inversely correlated with clinical severity of atopic dermatitis in children.

Keywords: Atopic dermatitis, 25-hydroxyvitamin D, SCORAD index

Figures and Tables

Fig. 1

Correlation of 25-hydroxyvitamin D with age (A), SCORing Atopic Dermatitis (SCORAD) index (B), total immunoglobulin E (IgE) (C), and C-reactive protein (CRP) (D). P<0.05 is statistically significant.

Fig. 2

Serum immunoglobulin E (IgE) (A), age (B), SCORing Atopic Dermatitis (SCORAD) index (C) according to the groups (group 1, 25-hydroxyvitamin D<20 ng/mL; group 2, 25-hydroxyvitamin D, 20-29 ng/mL; group 3, 25-hydroxyvitamin D≥30 ng/mL). Horizontal lines indicate mean values. P<0.05 is statistically significant.

Table 1

Clinical characteristics and laboratory findings of all patients

Values are presented as number (%) or mean±standard deviation.

SCORAD, SCORing Atopic Dermatitis; IgE, immunoglobulin E; ECP, eosinophil cationic protein.

Table 2

Comparison of characteristics and laboratory findings in study groups

Values are presented as number (%) or mean±standard deviation.

SCORAD, SCORing Atopic Dermatitis; IgE, immunoglobulin E; ECP, eosinophil cationic protein; WBC, white blood cell; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus.

^*One way analysis of variance. ^†Chi-square test.

Table 3

25-Hydroxyvitamin D and SCORAD index according to the seasons

Values are presented as number (%) or mean±standard deviation.

SCORAD, SCORing Atopic Dermatitis; Spring, Mar-May; Summer, Jun-Aug; Autumn, Sep-Oct; Winter, Nov-Feb.

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