Journal List > Korean J Gastroenterol > v.67(5) > 1007505

Lee: Fecal Calprotectin in Inflammatory Bowel Disease

Abstract

Inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis comprise conditions characterized by chronic, relapsing immune activation and inflammation within the gastrointestinal tract. Objective estimation of intestinal inflammation is the mainstay in the diagnosis and observation of IBD, but is primarily dependent on expensive and invasive procedures such as endoscopy. Therefore, a simple, noninvasive, inexpensive, and accurate test would be extremely important in clinical practice. Fecal calprotectin is a calcium-containing protein released into the lumen that is excreted in feces during acute and chronic inflammation. It is well-researched, noninvasive, and has high sensitivity and specificity for identification of inflammation in IBD. This review will focus on the use of fecal calprotectin to help diagnose, monitor, and determine treatment in IBD.

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Table 1.
Commercially Available Fecal Calprotectin Test
Category Test Manufacturer Method
Fully quantitative laboratory-based test EK-CAL ELISA test Bühlmann ELISA
  Calpro ELISA Calpro ELISA
  Calfast ELISA Eurospital ELSIA
  ELISA Immundiagnostik ELISA
  Immunocap Elia calprotectin Phadia Elia
Fully quantitative rapid tests LF-CAL25 Quantum blue Bühlmann Rapid test (immunoassay)
  Calfast Eurospital Rapid test
Semi-quantitative point-of-care tests CalDetect calprotectin rapid test Preventis Immunochromatography

ELISA, enzyme-linked immunosorbent assay.

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