Journal List > Korean J Gastroenterol > v.64(4) > 1007279

Kim: Standard Value of Serum Alanine Aminotransferase: Is It Fixed or Varied?

Abstract

Article

Detailed Distribution of Liver Enzymes according to Gender, Age, and Body Mass Index in Health Checkup Subjects

References

1. Kim WR, Flamm SL, Di Bisceglie AM, Bodenheimer HC. Public Policy Committee of the American Association for the Study of Liver Disease. Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology. 2008; 47:1363–1370.
crossref
2. Kim HC, Nam CM, Jee SH, Han KH, Oh DK, Suh I. Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. BMJ. 2004; 328:983.
crossref
3. Lee TH, Kim WR, Benson JT, Therneau TM, Melton LJ 3rd. Serum aminotransferase activity and mortality risk in a United States community. Hepatology. 2008; 47:880–887.
crossref
4. Sherman KE. Alanine aminotransferase in clinical practice. A review. Arch Intern Med. 1991; 151:260–265.
crossref
5. Pratt DS, Kaplan MM. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med. 2000; 342:1266–1271.
crossref
6. Fraser CG. Biological variation in clinical chemistry. An update: collated data, 1988–1991. Arch Pathol Lab Med. 1992; 116:916–923.
7. Córdoba J, O'Riordan K, Dupuis J, Borensztajin J, Blei AT. Diurnal variation of serum alanine transaminase activity in chronic liver disease. Hepatology. 1998; 28:1724–1725.
crossref
8. Dutta A, Saha C, Johnson CS, Chalasani N. Variability in the upper limit of normal for serum alanine aminotransferase levels: a statewide study. Hepatology. 2009; 50:1957–1962.
crossref
9. Prati D, Taioli E, Zanella A, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med. 2002; 137:1–10.
crossref
10. Piton A, Poynard T, Imbert-Bismut F, et al. Factors associated with serum alanine transaminase activity in healthy subjects: consequences for the definition of normal values, for selection of blood donors, and for patients with chronic hepatitis C. MULTIVIRC Group. Hepatology. 1998; 27:1213–1219.
11. Kunde SS, Lazenby AJ, Clements RH, Abrams GA. Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women. Hepatology. 2005; 42:650–656.
crossref
12. Choi SH, Yang JI, Lee C, et al. Detailed distribution of liver enzymes according to gender, age, and body mass index in health checkup subjects. Korean J Gastroenterol. 2014; 64:213–223.
crossref
13. Lee JK, Shim JH, Lee HC, et al. Estimation of the healthy upper limits for serum alanine aminotransferase in Asian populations with normal liver histology. Hepatology. 2010; 51:1577–1583.
crossref
14. Dufour DR. Alanine aminotransferase: is it healthy to be “normal”? Hepatology. 2009; 50:1699–1701.
crossref

Table 1.
Ninety-five Percentile of Upper Level of ALT and AST Value according to BMI
  BMI (kg/m2)
≤23.5
≤25
≤30
Total Male Female Total Male Female Total Male Female
ALT (IU/L) 42 50 34 46 55 36 56 66 39
AST (IU/L) 35 38 32 36 39 33 40 43 34

Data from the article of Choi, et al. (Korean J Gastroenterol 2014;64:213-223).12

TOOLS
Similar articles