Journal List > Korean J Nutr > v.42(5) > 1043776

Lee, Lee, Kim, Kim, and Lee: Analysis of Serum Antioxidant Materials Concentration and Their Relation with Blood Lipids and Anthropometric Indices in Middle-Aged Adults in Korea

Abstract

The serum levels of antioxidant materials (α-carotene, β-carotene, β-cryptoxanthin, lutein, lycopene, α-tocopherol, γ-tocopherol, retinol) of the healthy Korean middle-aged adults (n = 373) were measured and their relationships with the serum lipids and anthropometric indices were analyzed. The serum levels of β-cryptoxanthin, β-carotene, lutein were higher than those of lycopene and α-carotene. The levels of all measured carotenoids except lutein were significantly higher in females than in males, but retinol level was vice versa. There was a tendency of increase in serum levels of antioxidant vitamins with increasing age. The serum carotenoid levels had a positive correlation with serum cholesterol and a negative correlation with serum triglyceride. The serum levels of tocopherols or retinol showed a significantly positive relationship with blood cholesterol or triglyceride. In overall, anthropometric indices showed negative relations with serum carotenoids levels, but vice versa with serum tocopherol or retinol levels. Particularly, β-carotene and lutein levels showed a significantly negative relation with blood pressure in male subjects. The serum levels of α-carotene, β-carotene and β-cryptoxanthin had significantly negative relations with body fat-related indices in female subjects. The results demonstrated that blood antioxidants levels differed by sex and age, and had significant relations with blood lipid levels and anthropometric indices. Therefore, the rationale and significance of the relationships need to be elucidated in the future study related to dietary intakes and life style.

Figures and Tables

Table 1
Characteristics of the subjects
kjn-42-464-i001

1)Number (%), 2) Values are mean ± S.D.

*: indicates significant difference between two groups by Student's t-test (*: p < 0.05, **: p < 0.001)

NS: Not significantly different between two groups (p < 0.05), BMI: body mass index = Weight (kg)/Height (m)2, WHR: waist hip ratio = waist circumference/hip circumference, TBA: thiobarbituric acid

Table 2
Comparison of serum carotenoids, tocopherol and retinol concentrations by age and sex
kjn-42-464-i002

1)Values are mean ± S.D.

: indicates significant difference between two sex-groups by Student's t-test (: p < 0.05, ††: p < 0.001)

*: indicates significant difference between two age-groups in the same sex by Student's t-test (*: p < 0.05, **: p < 0.001)

Table 3
Distribution of the subjects according to nutritional status of serum α-tocopherol and retinol
kjn-42-464-i003
Table 4
Correlation coefficients of serum carotenoids, tocopherol and retinol concentrations with serum lipids
kjn-42-464-i004

1)indicates significant correlation between variables by Partial correlation coefficient (*: p < 0.05, **: p < 0.001)

Adjusted for sex, age

Table 5
Correlation coefficients of serum carotenoids, tocopherol and retinol concentration with serum and urine TBARS
kjn-42-464-i005

1)indicates significant correlation between variables by Partial correlation test (*: p < 0.05)

Adjusted for sex, age. TBARS: thiobarbituric acid-reactive substances

Table 6
Correlation coefficient of serum carotenoids, tocopherol and retinol concentration with anthropometric indices
kjn-42-464-i006

1)indicates significant correlation between variables by Partial correlation test (*: p < 0.05, **: p < 0.001)

Adjusted for age, total cholesterol

BMI: body mass index = Weight (kg)/Height (m)2, WHR: waist hip ratio = waist circumference/hip circumference, SBP: systolic blood pressure, DBP: diastolic blood pressure

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