Journal List > Tuberc Respir Dis > v.79(3) > 1002096

Kang, Cho, Han, Jung, Moon, Kim, Kim, Lee, Park, and Chung: IgG4-Related Lung Disease without Elevation of Serum IgG4 Level: A Case Report

Abstract

Since IgG4-related pancreatitis was first reported in 2001, IgG4-related disease has been identified in other organs such as salivary gland, gallbladder, thyroid, retroperitoneum and kidney; but lung invasion is rare. A 63-year-old man presented with hemoptysis at the pulmonary clinic and chest computed tomography revealed about 4.1 cm irregular shaped mass with spiculated margin at the left upper lobe. Despite no elevation of serum IgG4 level, he was finally diagnosed as IgG4-related lung disease by transthoracic needle biopsy. After treatment with oral glucocorticoids, hemoptysis disappeared and the size of lung mass was decreased.

Introduction

IgG4-related disease is newly recognized fibroinflammatory condition characterized by edema of invaded organ, a dense lymphoplasmacytic infiltration rich in IgG4-positive plasma cells, storiform pattern of fibrosis, and, often but not always, elevated serum IgG4 concentration level12. The most commonly involved organs are pancreas and salivary gland. It may also intrude thyroid, retroperitoneum, kidney, lung, and lymph node, but the invasion of lung is rare123. IgG4-related lung disease may be asymptomatic or has symptoms such as cough, hemoptysis, dyspnea, and chest pain123. IgG4-related lung disease could appear as solitary nodular lesion, thickening of bronchovascular bundles, interlobular septa, roundshaped ground-glass opacity (GGO), honeycombing, and bronchiectasis in chest computed tomography (CT), and it is difficult to discern that it comes from other lung diseases4.
In this paper, we report a case that a patient who came to hospital due to hemoptysis and had lung mass in chest CT was diagnosed IgG4-related disease by biopsy.

Case Report

A 63-year-old man visited the pulmonary clinic complaining hemoptysis which has lasted for 5 days. His past medical history were pulmonary tuberculosis (completely healed 20 years ago), diabetes mellitus, hypertension, and chronic kidney disease. He did not smoke and drink. There was no specific family history. Lung sound was clear and heart sound was normal without murmur. There was no palpable mass or lymph node in the neck. Blood pressure was 130/70 mm Hg, body temperature was 36.8℃, pulse rate was 92 beats per minute, and respiratory rate was 20 breaths per minute. Laboratory findings revealed hemoglobin 8.4 g/dL, white blood cell 4,530/mm3 (neutrophils, 64.3%; lymphocytes, 21.7%; eosinophils, 4.5%), platelets 234,000/mm3, C-reactive protein 1.10 mg/dL, aspartate aminotransferase 16 IU/L, alanine aminotransferase 9 IU/L, total bilirubin 0.26 IU/L, creatinine 2.72 mg/dL, blood urea nitrogen 33 mg/dL, and hemoglobin A1c 10.4%. In chest X-ray a simple mass was noted at left upper lobe, which was not found in the past film. In chest CT about 4.1-cm irregular shaped mass with spiculated margin was seen at left upper lobe (Figure 1A, B). We performed bronchoscopy and transthoracic needle biopsy. In bronchoscopy, there were no specific endobronchial findings and bronchial washing smear for acid-fast bacilli was negative. Transthoracic needle biopsy showed multiple scattered infiltrations of IgG4-positive plasma cells more than 40 in high-power field (Figure 2B), lymphoplasmacytic infiltration and a storiform pattern of fibrosis (Figure 2A). Although serum IgG (1,010 mg/dL; normal range, 670–1,600 mg/dL) and IgG4 (25.1 mg/dL; normal range, 6.1–121.4 mg/dL) levels were not elevated because the biopsy showed typical IgG4-related disease pathologic finding, we diagnosed as IgG4-related lung disease. There were no specific findings of pancreas in abdomen CT. After the patient was treated with oral glucocorticoids, hemoptysis disappeared and the size of mass was decreased (Figure 1C, D).

Discussion

Since IgG4-related pancreatitis was reported by Hamano et al. in 2001 for the first time5, IgG4-related disease has been identified in other organs such as salivary gland, gallbladder, thyroid, retroperitoneum, and kidney. The first case of IgG4-related lung disease in Korea was reported by Yoo et al. in 20096, and a few cases have been reported ever since. According to the presentation of Inoue et al. in 20094, IgG4-related lung disease could be categorized into four major subtypes: solid nodular type having a solitary nodular lesion that includes a mass; round-shaped GGO type characterized by multiple round-shaped GGOs; alveolar interstitial type showing honeycombing, bronchiectasis, and diffuse GGO; and bronchovascular type showing thickening of bronchovascular bundles and interlobular septa. In Korea, total nine cases of IgG4-related lung disease have been reported. These cases showed multiple lung nodules or mass67, consolidative mass8, pleural nodules or mass910, pleural effusion11, interstitial lung disease12, or bronchovascular bundle thickening13 in chest CT, and accompanying symptoms were cough, sputum, fever, dyspnea, or asymptomatic. All serum IgG4 levels in Korea cases elevated except the case of bronchial thickening with eosinophilic angiocentric fibrosis patient, in which case serum IgG level was normal and serum IgG4 level was not mentioned 678910111213. However, in our case presenting symptom was hemoptysis and serum IgG4 level was normal.
Solitary pulmonary lesion could be malignancy, infectious granuloma (e.g., aspergillosis and tuberculosis), harmatoma, or nonspecific granuloma14. Lesion larger than 3 cm was called mass and is often malignant14. Therefore, we performed biopsy.
The critical histopathologic features of IgG4-related disease are a dense lymphoplasmacytic infiltration, a storiform pattern of fibrosis, and obliterative phlebitis15. Furthermore, the diagnosis of IgG4-related disease rests on both presence of the characteristic histopathological appearance and increased numbers of IgG4-positive plasma cells infiltration. Elevated serum concentrations of IgG4 are found in approximately 70% of patients with IgG4-related disease1. In this case even though serum IgG4 level was normal, histopathologic feature of lung biopsy showed dense lymphoplasmacytic infiltration, storiform pattern of fibrosis (Figure 2A), and more than 40 IgG4-positive plasma cells in high-power field (Figure 2B). Thus, we diagnosed as IgG4-related lung disease.
Although the optimal treatment for IgG4-related disease has not been established yet, it has been known that glucocorticoids have an effect on most IgG4-related disease patients. The effects of glucocorticoids are alleviation of symptoms, reductions of mass size, improvement of organ function, and decrease in serum levels of IgG41. In this case patient was treated with methylprednisolone 0.4 mg/kg for 1 month and methylprednisolone was tapered. After 1 month of treatment, hemoptysis disappeared and lung mass size was decreased as well (Figure 1C, D).
This case showed that solitary lung mass with normal serum IgG4 level could be IgG4-related lung disease and IgG4-related lung disease could present hemoptysis.

Figures and Tables

Figure 1

Enhanced chest computed tomography (CT) findings. (A, B) Chest CT on admission day shows about 4.1-cm irregular shaped mass with spiculated margin at left upper lobe. (C, D) Chest CT after 1 month of treatment reveals mass size decreased to 3.6 cm.

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Figure 2

Histopathological findings of the lung. (A) Heavy infiltration of plasma cells, admixed with lymphocytes and neutrophils and storiform pattern of fibrosis are identified (H&E stain, ×200). (B) In IgG4 immunochemical staining, more than 40 multiple scattered infiltrations of IgG4-positive plasma cells are identified in high-power field (×400).

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Notes

Conflicts of Interest No potential conflict of interest relevant to this article was reported.

References

1. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012; 366:539–551.
2. Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003; 38:982–984.
3. Zen Y, Inoue D, Kitao A, Onodera M, Abo H, Miyayama S, et al. IgG4-related lung and pleural disease: a clinicopathologic study of 21 cases. Am J Surg Pathol. 2009; 33:1886–1893.
4. Inoue D, Zen Y, Abo H, Gabata T, Demachi H, Kobayashi T, et al. Immunoglobulin G4-related lung disease: CT findings with pathologic correlations. Radiology. 2009; 251:260–270.
5. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001; 344:732–738.
6. Yoo JW, Roh JH, Lim CM, Lee SD, Kim WS, Kim DS, et al. Two cases of pulmonary involvement of immunoglobulin G4 related autoimmune disease. Tuberc Respir Dis. 2009; 67:359–363.
7. Kwon SH, Lee YK, Shim MS, Lee HI. A case of immunoglobulin G4-related sclerosing disease mimicking lung cancer. J Korean Soc Radiol. 2013; 69:53–56.
8. Park HY, Han J, Kang G, Yi CA, Chung MP. IgG4-related lung disease presenting as a consolidative mass: a case report. J Lung Cancer. 2010; 9:103–105.
9. Kim DH, Koh KH, Oh HS, Kim SJ, Kang SH, Jung BW, et al. A case of immunoglobulin g4-related disease presenting as a pleural mass. Tuberc Respir Dis. 2014; 76:38–41.
10. Choi IH, Jang SH, Lee S, Han J, Kim TS, Chung MP. A case report of IgG4-related disease clinically mimicking pleural mesothelioma. Tuberc Respir Dis. 2014; 76:42–45.
11. Choi JH, Sim JK, Oh JY, Lee EJ, Hur GY, Lee SH, et al. A case of IgG4-related disease presenting as massive pleural effusion and thrombophlebitis. Tuberc Respir Dis. 2014; 76:179–183.
12. Ahn JH, Hong SI, Cho DH, Chae EJ, Song JS, Song JW. A case of IgG4-related lung disease presenting as interstitial lung disease. Tuberc Respir Dis. 2014; 77:85–89.
13. Kim WJ, Kim YI, Kim JE, Choi YH, Cho HH, Choi YD, et al. Unexplained persistent dyspnea in a young woman with eosinophilic angiocentric fibrosis. Respir Care. 2014; 59:e72–e76.
14. Ost D, Fein AM, Feinsilver SH. Clinical practice: the solitary pulmonary nodule. N Engl J Med. 2003; 348:2535–2542.
15. Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012; 25:1181–1192.
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