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Jung, Kim, Oh, Jung, Lee, Jung, Min, Lee, Lee, Kim, and Chung: p53, p21 and bcl-2 Protein Expressions and the Clinical Significance in Papillary Thyroid Carcinoma
Original Article
Journal of Korean Endocrine Society

Journal of Korean Endocrine Society 2007; 22(2): 98-104.

Published online: 20 April 2007

DOI: https://doi.org/10.3803/jkes.2007.22.2.98

p53, p21 and bcl-2 Protein Expressions and the Clinical Significance in Papillary Thyroid Carcinoma

Tae Sik Jung, Keun-Sook Kim1, Young Lyun Oh2, Jung Hwa Jung, Eun-Young Lee, Hye Seung Jung, Yong-Ki Min, Myung-Shik Lee, Moon-Kyu Lee, Kwang-Won Kim, Jae Hoon Chung

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.

1Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Korea.

2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.

Received 22 September 2006       Accepted 9 November 2006

Copyright © 2007 Korean Endocrine Society

Abstract

Background

There have been some investigations concerning the role of p53, p21 and bcl-2 protein expressions for the tumorigenesis of thyroid cancer. It had been debated that these protein expressions were associated with aggressive features of papillary thyroid carcinoma. We studied to evaluate the prevalence of these protein expressions and their clinical significances in papillary thyroid carcinoma.

Methods

We selected 49 patients with papillary thyroid carcinoma who had been operated on at Samsung Medical Center during the last 10 years. Immunohistochemical staining for p53, p21 and bcl-2 was done by the use of paraffin embedded tissues. We analyzed the results of immunohistochemical staining for p53, p21 and bcl-2 and the correlation with the patients' age, gender, tumor size, multifocality, tumor invasion to both lobes, extrathyroidal invasion, cervical lymph node invasion, distant metastasis and the clinical outcomes.

Results

Immunohistochemical staining for p53 was positive in 10 patients (20%), p21 was positive in 36 patients (73%) and bcl-2 was positive in 18 patients (37%). The p53 and bcl-2 expressions were not associated with the clinical parameters. Tumor multifocality and extrathyroidal invasion were significantly higher in the p21 positive group (both P < 0.05).

Conclusion

This study showed that the p21 protein expression was associated with tumor multifocality and extrathyroidal invasion in the patients with papillary thyroid carcinoma. Immunohistochemical stains for p21 may be used as a parameter for tumor aggressiveness in papillary thyroid carcinoma.

Keywords: bcl-2, Immunohistochemistry, Papillary thyroid carcinoma, p21, p53

Figures and Tables

Table 1
Analysis of clinicopathologic data according to the p53 immunohistochemical stains in papillary thyroid carcinoma
jkes-22-98-i001
Table 2
Analysis of clinicopathologic data according to the p21 immunohistochemical stains in papillary thyroid carcinoma
jkes-22-98-i002

*P value < 0.05 by Pearson's chi-square test.

Table 3
Analysis of clinicopathologic data according to the bcl-2 immunohistochemical stains in papillary thyroid carcinoma
jkes-22-98-i003

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