Journal List > Endocrinol Metab > v.27(2) > 1085947

TOOLS
Park, Oh, Shon, Kim, Jeon, and Jung: A Case of Dopamine-Secreting Pheochromocytoma
Case Report
Endocrinology and Metabolism

Endocrinology and Metabolism 2012; 27(2): 159-162.

Published online: 20 June 2012

DOI: https://doi.org/10.3803/EnM.2012.27.2.159

A Case of Dopamine-Secreting Pheochromocytoma

Jung Kyu Park1, Hoon Kyu Oh2, Moo Hyun Shon1, Hyun Hee Kim1, Eon Ju Jeon1, Eui Dal Jung1

1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.

2Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Korea.

Corresponding author: Eui Dal Jung. Department of Internal Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-gu, Daegu 705-718, Korea. Tel: +82-53-650-4218, Fax: +82-53-651-4009, Jed15@cu.ac.kr

Received 3 August 2011       Accepted 24 October 2011

Copyright © 2012 Korean Endocrine Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A pheochromocytoma is a neuroectodermal tumor that originates from the chromaffin cells of the sympathetic system. It has typical symptoms or signs, such as periodic attacks of paroxysmal hypertension, palpitation, headache, and sweating, related to an increased catecholamine secretion. Types of catecholamine secreted from tumors are usually norepinephrine and epinerphrine. There are a few reports of dopamine-secreting pheochromocytoma with absence of other catecholamines secretion. Here, we report the case of a 59-year-old man with dopamine-secreting pheochromocytoma, with no typical symptoms or signs.

Keywords: Dopamine, Pheochromocytoma

Figures and Tables

Fig. 1
Dynamic adrenal gland computed tomography. 2.7 cm-sized right adrenal mass is seen on pre-enhance phase (A) and arterial phase (B). Adrenal adenoma is highly suspicious.
enm-27-159-g001
Fig. 2
I131-MIBG scan. No evidence of significant radiotracer uptake in computed tomography-detected right adrenal mass. Lt, left; Rt, right.
enm-27-159-g002
Fig. 3
Histology. Dopamine-secreting pheochromocytoma (A) shows more strong staining than typical pheochromocytoma (B) and normal adrenal medulla (C) (dopamine IHC stain, × 200).
enm-27-159-g003

References

1. Ito Y, Fujimoto Y, Obara T. The role of epinephrine, norepinephrine, and dopamine in blood pressure disturbances in patients with pheochromocytoma. World J Surg. 1992. 16:759–763.
2. Yasunari K, Kohno M, Minami M, Kano H, Ohhira M, Nakamura K, Yoshikawa J. A dopamine-secreting pheochromocytoma. J Cardiovasc Pharmacol. 2000. 36:Suppl 2. S75–S77.
3. Dubois LA, Gray DK. Dopamine-secreting pheochromocytomas: in search of a syndrome. World J Surg. 2005. 29:909–913.
4. Bartolacci M, Bartolacci S, Leombruni E, Annunziata A, Di Rienzo M, Picardi N. Adrenal incidentaloma: a dopamine-secreting pheochromocytoma with an atypical clinical picture. A case report and review of the literature. Ann Ital Chir. 1998. 69:805–814.
5. Proye C, Fossati P, Fontaine P, Lefebvre J, Decoulx M, Wemeau JL, Dewailly D, Rwamasirabo E, Cecat P. Dopamine-secreting pheochromocytoma: an unrecognized entity? Classification of pheochromocytomas according to their type of secretion. Surgery. 1986. 100:1154–1162.
6. Jain SK, Agarwal N. Asymptomatic giant pheochromocytoma. J Assoc Physicians India. 2002. 50:842–844.
7. Minamiguchi N, Inui E, Nukui M. A case of dopamine-secreting pheochromocytoma. Hinyokika Kiyo. 1999. 45:831–833.
8. Van Der Horst-Schrivers AN, Osinga TE, Kema IP, Van Der Laan BF, Dullaart RP. Dopamine excess in patients with head and neck paragangliomas. Anticancer Res. 2010. 30:5153–5158.
9. van der Harst E, de Herder WW, Bruining HA, Bonjer HJ, de Krijger RR, Lamberts SW, van de Meiracker AH, Boomsma F, Stijnen T, Krenning EP, Bosman FT, Kwekkeboom DJ. [123I]metaiodobenzylguanidine and [111In] octreotide uptake in begnign and malignant pheochromocytomas. J Clin Endocrinol Metab. 2001. 86:685–693.
10. Pacak K, Linehan WM, Eisenhofer G, Walther MM, Goldstein DS. Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytoma. Ann Intern Med. 2001. 134:315–329.
TOOLS
Similar articles