In order to study the predisposing factors of splenic infarction, a retrospective review was done with the hepatic angiograms taken before and immediately after tanscatheter hepatic arterial embolization (THAE). Splenic infarction occurred in 5 cases as a complication of 220 procedures of in 70 patients of hepatocellular carcinoma. The CT findings of splenic infarction were well-defined peripheral low density of wedge shape in 2 patients, multiple low density areas in 2 patients and extensive inhomogeneous low density in one patient. To prevent refluxof embolic material in THAE. the amount of the embolic material should be adjusted according to the vascular flow volume of the liver. Flow changes due to vascular anatomical variations, arterial occlusions with collaterals, arterial spasm and localized arterial dissection should be taken into consideration before injection of embolic material.