Journal List > Lab Med Online > v.7(2) > 1057372

Lee, Park, Oh, Kim, and Kim: Two Clinical Cases of Anti-Dib with Di(a+b-) Phenotypes: Practical Need for Rare Blood Donor Registry Program in Korea

Abstract

Here, we report two cases of identified anti-Dib antibodies with rare Di(a+b-) blood types from two different hospitals in Korea. Dib mismatched transfusion could cause a hemolytic transfusion reaction. However, it is extremely difficult to find compatible blood for patients with such a rare blood type. In this regard, we concluded that national level rare donor registry program, wherein rare blood types are indexed, needs to be established. Moreover, laboratory medicine specialists at each hospital should encourage donor registration and family testing through education for helping patients with rare blood types. These efforts will help establish a system that guarantees safe blood transfusion for patients.

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Fig. 1.
Hemoglobin value of the patient in Case 1.
lmo-7-79f1.tif
Fig. 2.
Sequence analysis of SLC4A1. Arrow indicates homozygous substitution of proline (CCG) with leucine (CTG) at position 854 of exon 19.
lmo-7-79f2.tif
Fig. 3.
Proposed protocol after identifying rare blood type in a patient.
lmo-7-79f3.tif
Table 1.
Reported cases of adult patients having anti-Dib in Korea
Case Age/Sex Blood group Diego phenotype Unexpected antibody identification Diagnosis
1 [14] 57/F N/A Di(a+b−) anti-Dib Liver cancer
2 [present case] 78/F O+ Di(a+b−) anti-Dib Compartment syndrome
3 [present case] 73/F A+ Di(a+b−) anti-Dib, anti-C Humerus fracture
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