Autoimmune Hemolytic Anemia after Aplastic Crisis due to Parvovirus B19 Infection in a Patient with Hereditary Spherocytosis

Sae Am Song; Min-Young Lee; Si Hyun Kim; Ja Young Lee; Seung Hwan Oh; Jeong Hwan Shin; Hye Ran Kim; Kyung Ran Jun; Jeong Nyeo Lee

doi:10.3343/lmo.2012.2.3.166

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Song, Lee, Kim, Lee, Oh, Shin, Kim, Jun, and Lee: Autoimmune Hemolytic Anemia after Aplastic Crisis due to Parvovirus B19 Infection in a Patient with Hereditary Spherocytosis

Case Report

Diagnostic Hematology

Laboratory Medicine Online

Laboratory Medicine Online 2012; 2(3): 166-169.

Published online: 1 July 2012

DOI: https://doi.org/10.3343/lmo.2012.2.3.166

Autoimmune Hemolytic Anemia after Aplastic Crisis due to Parvovirus B19 Infection in a Patient with Hereditary Spherocytosis

Sae Am Song, M.D., Min-Young Lee, M.S., Si Hyun Kim, M.S., Ja Young Lee, M.D., Seung Hwan Oh, M.D., Jeong Hwan Shin, M.D., Hye Ran Kim, M.D., Kyung Ran Jun, M.D., Jeong Nyeo Lee, M.D.

Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea.

Corresponding author: Jeong Nyeo Lee, M.D. Department of Laboratory Medicine, Haeundae Paik Hospital, Inje University College of Medicine, 875 Haeundae-ro, Haeundae-gu, Busan 612-030, Korea. Tel: +82-51-797-3190, Fax: +82-51-797-3192, jeong418@medimail.co.kr

Received 9 January 2012 Revised 12 March 2012 Accepted 17 April 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hereditary spherocytosis (HS) is a genetic disorder characterized by the production and destruction of spherocytes due to a deficiency of red cell membrane cytoskeletal proteins, resulting in the clinical presentation of chronic hemolytic anemia. This disease can be accompanied by an aplastic crisis due to parvovirus B19 infection. Parvovirus B19 infection causes diseases such as erythema infectiosum and arthritis, and can also trigger various autoimmune diseases, including autoimmune hemolytic anemia (AIHA). Here, we report a rare case of AIHA developing 3 months after an aplastic crisis due to parvovirus B19 infection in an 11-year-old boy with HS and provide the relevant literature review.

Keywords: Hereditary spherocytosis, Parvovirus B19, Autoimmune hemolytic anemia

Figures and Tables

Fig. 1

Diagram of hemoglobin (Hb) and reticulocyte count (Reti) showing disease course during autoimmune hemolytic anemia following aplastic crisis due to parvovirus B19 infection. DAT represents direct antiglobulin test.

Notes

This article is available from http://www.labmedonline.org

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