Journal List > J Korean Ophthalmol Soc > v.58(2) > 1010696

Chung, Lee, Yoon, Kim, and Kim: Comparison of Inner Retinal Thickness between the Fellow Eyes of Unilateral Branch Retinal Vein Occlusion and Normal Control

Abstract

Purpose

The purpose of this study was to compare inner retinal thickness and retinal nerve fiber layer (RNFL) thickness be-tween fellow eyes with unilateral branch retinal vein occlusion (BRVO) and normal control eyes.

Methods

Retrospective cross-sectional study including 59 patients diagnosed with unilateral BRVO and 51 control subjects. Using spectral domain optical coherence tomography, we investigated the average, 4 quadrant, and 12 clock-hour RNFL thick-nesses and the average, minimum, superior, superonasal, superotemporal, inferior, inferonasal, and inferotemporal thicknesses of the ganglion cell-inner plexiform layer (GCIPL) layer.

Results

Patients with unilateral BRVO had a higher incidence of hypertension. In the fellow eyes of the unilateral BRVO pa-tients, 7 and 11 o’clock RNFL thicknesses were significantly thinner than for the control eyes. There was no significant difference in the GCIPL thickness between the two groups

Conclusions

The RNFL thickness of the fellow eyes of the unilateral BRVO patients showed significant decreases in the 7 and 11 o’clock sectors ( p=0.005, 0.017, respectively), whereas there was no significant difference in the GCIPL thickness between the two groups. In the RNFL thickness analysis, the 7 and 11 o’clock sectors were found to be dominant locations of decreased RNFL thickness for the open angle glaucoma. Further, glaucomatous change should be carefully monitored in the fellow eyes of unilateral BRVO patients.

References

1. Luntz MH, Schenker HI. Retinal vascular accidents in glaucoma and ocular hypertension. Surv Ophthalmol. 1980; 25:163–7.
crossref
2. Krakau CE. Disk hemorrhages and retinal vein occlusions in glaucoma. Surv Ophthalmol. 1994; 38(Suppl):S18–21.
crossref
3. Sonnsjö B, Krakau CE. Arguments for a vascular glaucoma etiology. Acta Ophthalmol (Copenh). 1993; 71:433–44.
crossref
4. Yoo YC, Park KH. Disc hemorrhages in patients with both normal tension glaucoma and branch retinal vein occlusion in different eyes. Korean J Ophthalmol. 2007; 21:222–7.
crossref
5. Rath EZ, Frank RN, Shin DH, Kim C. Risk factors for retinal vein occlusions. A case-control study. Ophthalmology. 1992; 99:509–14.
6. Risk factors for branch retinal vein occlusion. The Eye Disease Case-control Study Group. Am J Ophthalmol. 1993; 116:286–96.
7. Risk factors for central retinal vein occlusion. The Eye Disease Case-Control Study Group. Arch Ophthalmol. 1996; 114:545–54.
8. Stewart RM, Clearkin LG. Insulin resistance and autoregulatory dysfunction in glaucoma and retinal vein occlusion. Am J Ophthalmol. 2008; 145:394–6.
crossref
9. Bonovas S, Peponis V, Filioussi K. Diabetes mellitus as a risk fac-tor for primary open-angle glaucoma: a meta-analysis. Diabet Med. 2004; 21:609–14.
10. Ellis JD, Evans JM, Ruta DA. . Glaucoma incidence in an un-selected cohort of diabetic patients: is diabetes mellitus a risk fac-tor for glaucoma? DARTS/MEMO collaboration. Diabetes Audit and Research in Tayside Study. Medicines Monitoring Unit. Br J Ophthalmol. 2000; 84:1218–24.
11. Pasquale LR, Kang JH, Manson JE. . Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women. Ophthalmology. 2006; 113:1081–6.
crossref
12. Gordon MO, Beiser JA, Brandt JD. . The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002; 120:714–20.
13. Hulsman CA, Vingerling JR, Hofman A. . Blood pressure, ar-terial stiffness, and open-angle glaucoma: the Rotterdam study. Arch Ophthalmol. 2007; 125:805–12.
14. Kim MJ, Woo SJ, Park KH, Kim TW. Retinal nerve fiber layer thickness is decreased in the fellow eyes of patients with unilateral retinal vein occlusion. Ophthalmology. 2011; 118:706–10.
crossref
15. Quigley HA, Addicks EM. Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol. 1981; 99:137–43.
crossref
16. Jonas JB, Gusek GC, Naumann GO. Optic disc morphometry in chronic primary open-angle glaucoma. I. Morphometric intra-papillary characteristics. Graefes Arch Clin Exp Ophthalmol. 1988; 226:522–30.
17. Janáky M, Grósz A, Tóth E. . Hypobaric hypoxia reduces the amplitude of oscillatory potentials in the human ERG. Doc Ophthalmol. 2007; 114:45–51.
crossref
18. Tinjust D, Kergoat H, Lovasik JV. Neuroretinal function during mild systemic hypoxia. Aviat Space Environ Med. 2002; 73:1189–94.
19. Chhablani J, Rao HB, Begum VU. . Retinal ganglion cells thin-ning in eyes with nonproliferative idiopathic macular telangiectasia type 2A. Invest Ophthalmol Vis Sci. 2015; 56:1416–22.
crossref
20. Jeoung JW, Choi YJ, Park KH, Kim DM. Macular ganglion cell imaging study: glaucoma diagnostic accuracy of spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2013; 54:4422–9.
crossref
21. Nouri-Mahdavi K, Nowroozizadeh S, Nassiri N. . Macular ganglion cell/inner plexiform layer measurements by spectral do-main optical coherence tomography for detection of early glauco-ma and comparison to retinal nerve fiber layer measurements. Am J Ophthalmol. 2013; 156:1297–307.e2.
crossref
22. Seong M, Sung KR, Choi EH. . Macular and peripapillary retinal nerve fiber layer measurements by spectral domain optical coher-ence tomography in normal-tension glaucoma. Invest Ophthalmol Vis Sci. 2010; 51:1446–52.
crossref

Figure 1.
Photographs of the retinal nerve fiber layer (RNFL) of a 65 year old man with branch retinal vein occlusion (BRVO) (A, B). This patient had BRVO in the left eye (B) and red-free fundus photography showed a wedge-shaped defect (between arrows) in the right eye (A). Optical coherence tomography (C) of the right eye showed that RNFL thickness was identified as abnormal by the <1% criterion from 10-o’clock to 11-o’clock area. Ganglion cell analysis map of the right eye showed thinning of the ganglion cell-inner plexiform layer (red color area) on deviation map of right eye. A glaucomatous visual field change was noted in the corre-sponding hemifield location (D). TEMP = temporal; SUP = superior; NAS = nasal; INF = inferior; S = superior; N = nasal; I = inferior; T = temporal; MD = mean deviation; PSD = pattern standard deviation.
jkos-58-165f1.tif
Table 1.
Characteristics of RVO fellow eyes and control groups
RVO Fellow eye (n = 59) Control (n = 48) p-value
Age (years) 63.4 ± 9.6 62.9 ± 9.8 0.763*
Gender (male/female) 18/41 15/33 0.934
Hypertension (n) 30 13 0.013
Diabetes mellitus (n) 12 3 0.037
Refraction (D) -0.12 ± 1.51 0.16 ± 1.09 0.204*
Mean IOP (mmHg) 14.98 ± 3.17 15.73 ± 3.69 0.234*

Values are presented as mean ± SD unless otherwise indicated.

RVO = retinal vein occlusion; D = diopter; IOP = intraocular pressure.

* By student t-test

By chi-square test.

Table 2.
Comparison between RNFL thickness in the fellow eyes of RVO patients and controls
RNFL thickness (μ m) RVO fellow eye (μ m) (n = 59) Control (μ m) (n = 48) p-value*
Average RNFL thickness 87.87 ± 11.09 89.00 ± 7.46 0.705
Superior quadrant 107.29 ± 17.05 109.28 ± 15.06 0.286
Nasal quadrant 63.85 ± 8.98 66.34 ± 7.06 0.104
Inferior quadrant 111.91 ± 22.05 114.69 ± 12.38 0.551
Temporal quadrant 65.97 ± 10.54 65.51 ± 9.70 0.821
1-o’clock 101.04 ± 21.35 100.45 ± 22.18 0.390
2-o’clock 75.51 ± 14.94 77.52 ± 13.23 0.704
3-o’clock 55.73 ± 7.87 55.62 ± 7.98 0.764
4-o’clock 60.36 ± 10.00 61.76 ± 8.08 0.688
5-o’clock 105.43 ± 26.40 105.75 ± 24.28 0.911
6-o’clock 121.73 ± 22.54 123.39 ± 28.43 0.871
7-o’clock 118.04 ± 22.16 134.87 ± 18.40 0.005
8-o’clock 67.28 ± 14.34 66.91 ± 13.48 0.684
9-o’clock 54.93 ± 8.65 54.62 ± 7.80 0.391
10-o’clock 75.32 ± 13.35 76.19 ± 14.94 0.704
11-o’clock 112.59 ± 21.83 124.24 ± 17.42 0.017
12-o’clock 118.49 ± 19.24 115.76 ± 20.51 0.063

Values are presented as mean ± SD unless otherwise indicated.

RNFL = retinal nerve fiber layer; RVO = retinal vein occlusion.

* By student t-test.

Table 3.
Comparison between GCIPL thickness in the fellow eyes of RVO patients and controls
GCIPL thickness (μ m) RVO Fellow eye (μ m) (n = 59) Control (μ m) (n = 48) p-value*
Average 79.05 ± 11.22 80.08 ± 6.64 0.640
Minimum 73.52 ± 13.97 76.77 ± 8.91 0.223
Superornasal 81.46 ± 12.33 81.33 ± 7.36 0.995
Superior 79.32 ± 12.07 80.23 ± 6.23 0.375
Superotemporal 78.43 ± 11.63 79.33 ± 5.99 0.223
Inferotemporal 79.51 ± 10.46 80.54 ± 7.47 0.600
Inferior 76.68 ± 12.64 79.29 ± 7.06 0.395
Inferonasal 78.13 ± 13.04 79.37 ± 8.94 0.986

Values are presented as mean ± SD unless otherwise indicated.

GCIPL = ganglion cell-inner plexiform layer; RVO = retinal vein occlusion.

* By student t-test.

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