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Jeon and Kyung: The Change of Multifocal Visual Evoked Potential in Unilateral Anisometropic Amblyopia before and after Occlusion Treatment
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(12): 1851-1856.

Published online: 17 December 2012

DOI: https://doi.org/10.3341/jkos.2012.53.12.1851

The Change of Multifocal Visual Evoked Potential in Unilateral Anisometropic Amblyopia before and after Occlusion Treatment

Ji Hoon Jeon, MD, Sung Eun Kyung, MD, PhD

Department of Ophthalmology, Dankook University College of Medcine, Cheonan, Korea.

Address reprint requests to Sung Eun Kyung, MD, PhD. Department of Ophthalmology, Dankook University Hospital, #201 Manghyang-ro, Dongnam-gu, Cheonan 330-715, Korea. Tel: 82-41-550-6497, Fax: 82-41-561-0137, kseeye@hanmail.net

Received 13 March 2012       Accepted 29 October 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To evaluate the change in multifocal visual evoked potential (mfVEP) in unilateral anisometropic amblyopia before and after occlusion treatment.

Methods

The mfVEP was performed using RETIscan® (Roland,Brandenburg, Germany) for patients with unilateral anisometropic amblyopia before and after occlusion treatment. Amplitude and latency values of mfVEP were analyzed according to the field divided by 6 rings or 4 sectors.

Results

The each amplitude of values of all 6 rings were not significantly different before treatment (p = 0.077) in amblyopic eyes. However, the value of ring 1 (p = 0.00) was significantly higher than the value of other rings after treatment. In fellow eyes, the values of ring 1 was consistently significantly higher than the value of other rings before (p = 0.014) and after (p = 0.049) occlusion treatment. Additionally, the amplitudes of ring 1 (p = 0.005) and ring 3 (p = 0.007) were significantly increased in amblyopic eyes after occlusion treatment. In fellow eyes, the values of all rings did not change significantly. The analysis of amplitudes with 4 sectors revealed no significant result. The analysis of latencies with 6 rings and 4 sectors revealed no significant result.

Conclusions

The change in amplitude on the central field (ring 1) in amblyopic eyes can be a useful objective monitoring method observing the improvement progress in visual acuity.

Keywords: Anisometropic amblyopia, Multifocal visual evoked potential, Occlusion treatment, Ring 1

Figures and Tables

Figure 1
Amplitudes (µV) and latencies (ms) of P1on 6 rings (A) and 4 sectors (B).
jkos-53-1851-g001
Figure 2
Amplitudes of 6rings at before (A) and after (B) treatment in amblyopic eyes, at before (C) and after (D) treatment in fellow eyes. In amblyopic eyes, the values of each rings were not different significantly before treatment. However, the values of ring1 (central field) were significantly higher than those of other rings after treatment (p = 0.00). In fellow eyes, the values of ring1 (central field) were significantly higher than those of other rings before treatment (p = 0.014) and after treatment (p = 0.049).
jkos-53-1851-g002
Table 1
Clinical data
jkos-53-1851-i001

BCVA = best corrected visual acuity.

Table 2
Amplitude values of multifocal visual evoked potentials for rings in amblyopic and fellow eyes
jkos-53-1851-i002

Values are presented as mean ± SD (µV).

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