Journal List > J Korean Ophthalmol Soc > v.50(4) > 1008525

Park, Cho, and Moon: The Effects of Prostaglandin Analogues on the Corneal Thickness

Abstract

Purpose

To evaluate the effects of prostaglandin analogues on the corneal thickness of patients with primary open-angle glaucoma (POAG) or normal tension glaucoma (NTG).

Methods

This study included 130 eyes of 65 patients who were diagnosed with POAG or NTG. All patients were divided into two groups; one group received prostaglandin analogues, while the other group received alternative ocular hypotensive eyedrops. Corneal thickness, best corrected visual acuity, and flare in the anterior chamber were measured and compared before treatment and at least 24 months (mean: 27 months) after treatment.

Results

The mean decrease in corneal thickness was statistically significant in the group using prostaglandin analogues, but not in the control group. Among the various prostaglandin analogues used, travoprost and latanoprost decreased mean corneal thickness, but bimatoprost had no effect. Best corrected visual acuity, refraction power, and flare in the anterior chamber did not change significantly in either group of patients when ocular hypotensive eyedrops were used.

Conclusions

Prostaglandin analogues lower intraocular pressure and decrease corneal thickness if used over a 24 months.

References

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Figure 1.
Comparison of central corneal thickness between before and about 27 months after ocular hypotensive eye drops. (*1 p=0.055, *2 p<0.001)
jkos-50-565f1.tif
Figure 2.
Comparison of upper corneal thickness between before and about 27 months after ocular hypotensive eye drops. (*1 p=0.919, *2 p<0.001)
jkos-50-565f2.tif
Figure 3.
Comparison of lower corneal thickness between before and about 27 months after ocular hypotensive eye drops. (*1p=0.269, *2p=0.203)
jkos-50-565f3.tif
Figure 4.
Comparison of medial corneal thickness between before and about 27 months after ocular hypotensive eye drops. (*1 p=0.057, *2 p<0.001)
jkos-50-565f4.tif
Figure 5.
Comparison of temporal corneal thickness between before and about 27 months after ocular hypotensive eye drops. (*1 p =0.270, *2 p =0.001)
jkos-50-565f5.tif
Table 1.
Demographics
  Test group* Control group p-value
Eye 70 60  
Age (years) 56.25±15.07 (25∼78) 54.04±11.73 (38∼78) 0.581
Gender (F:M) 38: 32 34: 26 0.494
Mean duration of using ocular hypotensive eye drops (months) 27.11±13.88 28.14±12.14 0.793

* Group using eye drops of prostaglandin analogue

Group using other ocular hypotensive eye drops.

Table 2.
Corneal thickness (µm) before using ocular hypotensive eye drops
  Test group* Control group p-value
Central cornea 562.38±37.49 558.32±28.42 0.604
Upper cornea 620.54±32.17 615.28±34.55 0.611
Lower cornea 596.98±48.27 603.28±39.48 0.635
Medial cornea 612.48±38.38 618.56±44.29 0.455
Temporal cornea 590.19±43.56 587.29±41.29 0.594

Results are given in mean (± standard deviation).

* Group using eye drop of prostaglandin analogue

Group using other ocular hypotensive eye drops.

Table 3.
Corneal thickness (µm) after using ocular hypotensive eye drop
  Test group*(Change from screening, % Change from screening) Control Group (µm)(Change from screening, % Change from screening)
Central cornea 546.24±34.29 550.81±47.57
  (−16.14, 2.9%) (−7.51, 1.3%)
Upper cornea 604.32±45.07 614.47±33.53
  (−16.22, 2.6%) (−0.81, 0.0%)
Lower cornea 590.15±32.48 598.58±47.28
  (−6.83, 1.1%) (−4.7, 0.8%)
Medial cornea 591.01±41.28 608.89±44.11
  (−21.47, 3.5%) (−9.67, 1.7%)
Temporal cornea 571.84±48.55 577.08±28.89
  (−18.35, 3.1%) (−10.21, 1.7%)

Results are given in mean (± standard deviation) s.

* Group using eye drops of prostaglandin analogues

Group using other ocular hypotensive eye drops

Change from screening and percent change from screening are calculated on the basis of the mean of each patient's individual changes.

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