Analysis of Characteristics and Steroid Effects in Olfactory Dysfunction Patients

Choi, Sung Ho; Kim, Seon Tae; Park, Hyoung Min; Moon, Kwang Ha; Jung, Joo Hyun; Cha, Heung Eog

doi:10.18787/jr.2016.23.1.39

Original Article


J Rhinol. 2016 May;23(1):39-43. Korean. Published online May 31, 2016. https://doi.org/10.18787/jr.2016.23.1.39
Copyright © 2016 The Korean Rhinologic Society


Analysis of Characteristics and Steroid Effects in Olfactory Dysfunction Patients
Sung Ho Choi, MD, Seon Tae Kim, MD, Hyoung Min Park, MD, Kwang Ha Moon, MD, Joo Hyun Jung, MD and Heung Eog Cha, MD
Department of Otolaryngology Head and Neck Surgery, Gachon University, Incheon, Korea.
Corresponding author (Email: atmaasiris@gmail.com )

Received March 23, 2016; Revised May 16, 2016; Accepted May 25, 2016.
This article has been cited by 2 articles in KoMCI. This article has been cited by Google Scholar.
Go to: Abstract
Background and Objectives Olfactory dysfunction is a common sensory disorder, but there are currently no standard diagnostics or therapeutic methods. We analyzed the effects of systemic steroid therapy in patients with olfactory dysfunction. Materials and Method We analyzed patients who visited our ENT department with olfactory dysfunction for 3 years. We reviewed their charts and classified the patients according to age, sex, etiology of olfactory dysfunction, degrees of olfactory dysfunction and the effect of systemic steroid therapy. Results The mean age was 44.3 years old and there were 50 males and 55 females; 55 patients had inflammatory disease and 50 patients had non-inflammatory disease. The distribution of degrees of olfactory disorder according to cause was not significantly different (p=0.120). In 105 patients, 20% experienced improvements after systemic steroid therapy, and the response of systemic steroid therapy was better among patients with inflammatory causes. In cases of inflammatory disease, there was a larger amount of severe hyposmia patients, and their response to systemic steroid therapy was significant (p=0.015). Patients with mild and moderate hyposmia were more responsive to systemic steroid therapy than patients with severe hyposmia (p=0.382). Conclusion In cases of hyposmia due to inflammatory disease, systemic steroid therapy with proper operative management may increase therapeutic effects.


Keywords: Hyposmia; Steroid

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Tables


	Table 1 Distribution in casual group of olfactory dysfunction and average of identification score in T&T olfactometer
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	Table 2 Distribution of degree of olfactory disorder according to cause of olfactory dysfunction
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	Table 3 The response of steroid therapy
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	Table 4 Response of steroid therapy according to causes of olfactory dysfunction
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	Table 5 Response after steroid therapy according to degree of olfactory dysfunction
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References


1.	Min YG, Lee CH, Kwon TY, Lee CH, Yun JB, Lee KS. Quantitative Evaluation of Systemic Steroid Therapy for the Patients with Olfactory Dysfunction. Korean J Otolaryngol-Head Neck Surg 1998;41(1):37–41.

2.	Hong SC, Yoo YS, Kim SC, Kim YC, Kim YS. Transition of the Olfactory Recovery in Patients with Olfactory Disturbance. Korean J Otolaryngol-Head Neck Surg 2000;43:844–848.

3.	Takagi SF. Standardized olfactometries in Japan-a review over ten years. Chem Senses 1989;14:25–46.

4.	Dhong HJ, Shin DB, Rho HI, Chung SK, Chu KC. Clinical Analysis of Olfactory Disorders. Korean J Otolaryngol-Head Neck Surg 2001;44:946–950.

5.	Scott AE. Clinical characteristic of taste and smell disorders. Ear Nose Throat J 1989;68:297–298. 301, 304–310.

6.	Jafek BW, Moran DT, Eller PM, Carter JR, Jafek TB. Steroid-dependent anosmia. Arch Otolaryngol Head Neck Surg 1987;113:547–549.

7.	Cain WS, Gent JF, Goodspeed RB, Leonard G, Haven N. Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 1998;98:83–88.

8.	Duncan HJ, Seiden AM. Long-term follow-up of olfactory loss secondary to head trauma and upper respiratory tract infection. Arch Otolaryngol Head Neck Surg 1995;121:1183–1187.

9.	Schriever VA, Merkonidis C, Gupta N, Hummel C, Hummel T. Treatment of smell loss with systemic methylprednisolone. Rhinology 2012;50:284–289.

*10.*	Davidson TM, Murphy C, Jalowayski AA. Smell impairment: Can it be reversed? Postgrad Med 1995;98:107–109. 112–118.

*11.*	Cain WS. Testing olfaction in a clinical setting. Ear Nose Throat J 1989;68:316, 322–328.

*12.*	Hopkins RL, Leinung MC. Exogenous Cushing's Syndrome and Glucocorticoid Withdrawal. Endocrinol Metab Clin North Am 2005;34:371–384. ix.

*13.*	Park YJ. Functional Activity of the Central Olfactory Pathways. J Rhinol 2006;13(1):10–17.

*14.*	Park HJ, Lee SS, Byun SW, Bae JH. Alteration of Olfactory Function in Chronic Viral Hepatitis Patients. J Rhinol 2009;16(2):95–98.

*15.*	Wolfensberger M, Hummel T. Anti-inflammatory and Surgical Therapy of Olfactory Disorder Related to Sino-nasal Disease. Chem Senses 2002;27:617–622.

*16.*	Min Y, Son BH, Lee KS, Yun JB, Shin JS, Yoo YS. Olfaction changes after endoscopic sinus surgery. Korean J Otolaryngol-Head Neck Surg 1994;37:710–717.