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Jeon, Chung, Kim, Jun, Hwang, and Park: A Prospective, Randomized and Controlled Study for the Efficacy and Safety of Sedation Technique for Implant Surgery by Combining Nitrous Oxide and Intravenous Midazolam
Original Article

Journal of the Korean Dental Society of Anesthesiology 2012; 12(2): 69-74.

Published online: 30 May 2016

DOI: https://doi.org/10.17245/jkdsa.2012.12.2.69

A Prospective, Randomized and Controlled Study for the Efficacy and Safety of Sedation Technique for Implant Surgery by Combining Nitrous Oxide and Intravenous Midazolam

Seung-Hwan Jeon, Shin-Hye Chung*, Kwang-Soo Kim†, Sang-Ho Jun‡, Kyung-Gyun Hwang, Chang-Joo Park

Division of Oral and Maxillofacial Surgery, College of Medicine, Hanyang University, Seoul, Korea.

*Division of Conservative Dentistry, College of Medicine, Hanyang University, Seoul, Korea.

†Division of Preventive Dentistry, Department of Dentistry, College of Medicine, Hanyang University, Seoul, Korea.

‡Department of Oral and Maxillofacial Surgery, Korea University Anam Hospital, Korea University, Seoul, Korea.

Corresponding Author: Chang-Joo Park, Room 421, Division of Oral and Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul, 133-791, Korea. Tel: +82.2.2290.8646, Fax: +82.2.2290.8673, fastchang@hanyang.ac.kr

Received 15 June 2012       Revised 27 June 2012       Accepted 2 July 2012

Copyright © 2012 Journal of the Korean Dental Society of Anesthesiology

(open-access, http://creativecommons.org/licenses/by-nc/3.0/):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

The purpose of this study is to investigate the efficacy and safety of the sedation technique for implant surgery by combining the use of inhalation of nitrous oxide/oxygen with intravenous midazolam.

Methods

Patients requiring surgery for the placement of dental implants were randomly allocated to two groups receiving intravenous midazolam or a combined technique using nitrous oxide/oxide and intravenous midazolam. Safety parameters, cooperation scores, anxiety scales, total amount of midazolam administered and recovery time were recorded and compared.

Results

There were a statistically significant reduction in the amount of midazolam required to achieve optimal sedation (P<0.01), an overall significant reduction in recovery time (P<0.01), a significant reduction in anxiety scales (P<0.05), and a significant improvement in cooperation (P<0.05) and peripheral oxygen saturation (P<0.05) when a combined technique of inhalational N2O/O2 and midazolam was used.

Conclusions

For implant surgery, this combining sedation technique could be safe and reliable, demonstrating reduction of total dose of midazolam and level of patient's anxiety and improvement in patient's recovery and cooperation.

Keywords: Anesthetics, inhalation, Anesthetics, intravenous, Conscious sedation, Dental implants, midazolam, Nitrous oxide

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