The aim of this study was to examine the difference of SpO₂, PR, EtCO₂, RR with submucosal injection of midazolam to oral chloral hydrate and hydroxyzine for pediatric patients

Thirty two sedation cases were performed in this study. Patients were randomly classified into one group taking oral CH (60 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.1 mg/kg) and the other group recieving oral CH (50 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.2 mg/kg). For evaluating the depth of sedation, data including saturation percentage of oxygen (SpO₂), pulse rate (PR), end-tidal carbon dioxide (EtCO₂), respiratory rate (RR) and the behavior scale were checked every 2 minutes and were collected for only 40 minutes from the beginning of treatment and were analyzed using Two independent sample T-test.

Analysis showed no significant difference in the mean SpO₂, PR, EtCO₂, RR during sedation between two groups (P>0.05). The values of SpO₂, PR, EtCO₂ and RR for both groups remained within the normal values.

The results of this present study indicate that combination of oral CH, hydroxyzine, nitrous oxide gas inhalation and submucosal injection of midazolam improved the sedation quality without compromising safety.