Journal List > Korean J Endocr Surg > v.7(4) > 1060308

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Ji, Bae, Woo, Son, Lee, Koo, and Chae: The Significance of bcl-2 and P53 Expressions in the Papillary Thyroid Cancer
Original Article

Korean Journal of Endocrine Surgery 2007; 7(4): 231-236.

Published online: 31 December 2007

DOI: https://doi.org/10.16956/kjes.2007.7.4.231

The Significance of bcl-2 and P53 Expressions in the Papillary Thyroid Cancer

Woong Bae Ji, M.D., Jeoung Won Bae, M.D., Sang Uk Woo, M.D., Gil Soo Son, M.D., Jae Bok Lee, M.D., Bum Whan Koo, M.D., Yang-Seok Chae, M.D.1

Department of Surgery, Korea University College of Medicine, Seoul, Korea.

1Department of Pathology, Korea University College of Medicine, Seoul, Korea.

Correspondence: kujwbae@korea.ac.kr

      Accepted 15 December 2007

Copyright © 2007 Korean Association of Thyroid and Endocrine Surgeons; KATES

(open-access):

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

Papillary thyroid cancer (PTC) has a good prognosis, and it's known to be related to the apoptosis of papillary thyroid cancer. The expression of bcl-2 is thought to be associated with the inhibition of apoptosis. We evaluated the differences of bcl-2 and P53 between PTC and the control (normal tissue and benign lesion). We then analyzed the correlation between the bcl-2 and P53 expressions and the classic prognostic factors.

Methods

Between January 2001 and December 2005, 30 patients who underwent total thyroidectomy for the PTC were included in this study and immunohistochemical staining was performed on the tumors.

Results

bcl-2 was expressed in 18 cases (60%) in their PTC (P<0.05). The expression of P53 was not significantly related with the clinicopathological factors, but P53 was expressed in 9 cases (30%) of PTC (P<0.05). The positive staining for was noted in 18 cases (62.1%) of the PTC tissue among the 30 patients, and as the TNM stage progresses, the expression rate of was significantly decrease for 7 stage I cases (100%), for 4 stage ll cases (80%) and for 7 stage ll cases (38.9%).

Conclusion

bcl-2 was expressed more as the TNM stage of PTC decreases. So bcl-2 is possibly useful as a prognostic factor for PTC, but further studies are needed for confirming its significance. (

Keywords: Papillary thyroid cancer, Prognostic factor, bcl-2, P53

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