Journal List > J Cardiovasc Ultrasound > v.16(4) > 1018084

Moon, Hur, Ak, Park, Kim, Lee, Lee, Cho, and Kim: The Limitation in Measurement of Carotid Intima Media Thickness in Type 2 Diabetics with or without Coronary Artery Disease

Abstract

Background

The measurement of carotid intima-media thickness (IMT) is useful for detection of early atherosclerotic disease. But, IMT are influenced by various factors including hypertension, age, diabetes, etc. We tried to estimate the correlation between carotid IMT and coronary artery disease in diabetics.

Methods

The B-mode ultrasonography and coronary angiography was perfomed in 50 as type 2 diabetes and 226 as nondiabetes. Carotid IMT was measured at around carotid bulb. Coronary artery lesions was evaluated based on quantitative coronary analysis (QCA) from coronary angiogram.

Results

Type 2 diabetic group (mean age 64.5±8.9 years old) included 21 patients without coronary artery disease and 29 patients with coronary artery disease. Non-diabetic group (mean age 61.0±10.1) included 138 patients without coronary artery disease and 88 patients with coronary artery disease. In type 2 diabetic group, the mean value of measured max IMT of subjects with coronary artery disease was similar to that of subjects without coronary disease (mean Rt. IMT, 1.26±0.62 mm vs. 1.03±0.29 mm, respectively, p=0.11, mean Lt IMT, 1.30±0.70 mm vs. 1.17±0.43 mm, respectively, p=0.46). But in non-diabetic group, the mean value of measured max IMT of subjects with coronary artery disease was more than that of subjects without coronary disease, and it is statistically significant (mean Rt. IMT, 1.09±0.32 mm vs. 0.96±0.25 mm, respectively, p=0.01, mean Lt IMT, 1.19±0.47 mm vs. 1.01±0.32 mm, respectively, p=0.01).

Conclusion

This study shows weak correlation power between carotid IMT and coronary artery diseases in diabetics, contrast to non-diabetes.

Figures and Tables

Table 1
Clinical baseline characterisitcs of Non-DM group and DM group
jcu-16-116-i001

Data: mean±SD. *P-value from T-test, P-value from chi-squared test. CAD: coronary artery disease, BP: blood pressure, BMI: body mass index, HTN: hypertension, TG: triglyceride, LDL: low density lipoprotein, BUN: blood urea nitrogen, Cre: creatinine, CRP: C-reactive protein, NT-proBNP: N-terminal pro-brain natriutric peptide, LVEF: left ventricular ejection fraction, NS=not significant

Table 2
Characteristics of coronary artery lesions and PCI in Non-DM group and DM group
jcu-16-116-i002

Data: mean±SD. *P-value from chi-squared test. PCI: percutaneaous coronary intervention, LAD: left anterior, descending, LCX: left circumflex, RCA: right coronary artery

Table 3
Characteristics of IMT in Non-DM group and DM group
jcu-16-116-i003

Data: mean±SD (mm). *P-value from analysis of covariance (ANCOVA) which is performed after adjusting age, P-value from Wilcoxon's rank-sum test. IMT: intima media thickness, Rt.: right, Lt.: left

Table 4
Clinical baseline characterisitcs of Non-CAD and CAD in Non-DM group
jcu-16-116-i004

Data: mean±SD. *P-value from T-test, P-value from chi-squared test. CAD: coronary artery disease, BP: blood pressure, BMI: body mass index, HTN: hypertension, TG: triglyceride, LDL: low density lipoprotein, BUN: blood urea nitrogen, Cre: creatinine, CRP: C-reactive protein, NT-proBNP: N-terminal probrain natriutric peptide, LVEF: left ventricular ejection fraction, NS: not significant

Table 5
Clinical baseline characterisitcs of Non-CAD and CAD in DM group
jcu-16-116-i005

Data: mean±SD. *P-value from T-test, P-value from Fisher's Exact test, P-value from Wilcoxon's rank-sum test. CAD: coronary artery disease, BP: blood pressure, BMI: body mass index, HTN: hypertension, TG: triglyceride, LDL: low density lipoprotein, BUN: blood urea nitrogen, Cre: creatinine, CRP: C-reactive protein, NT-proBNP: N-terminal pro-brain natriutric peptide, LVEF: left ventricular ejection fraction, NS: not significant

Table 6
Measurement values of carotid IMT in subgroups with CAD or Non-CAD in Non-DM group and DM group
jcu-16-116-i006

Data: mean±SD. *P-value from T-test, P-value from Wilcoxon's rank-sum test. CAD: coronary artery disease, IMT: intima media thickness, Rt.: right, Lt.: left

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