Trial of Metoclopramide on Oro-facial Dyskinesia Following Traumatic Brain Injury: A Case Report

Seung Ki Kim; Joon Yeop Kim; Hyoung Seop Kim

doi:10.12786/bn.2014.7.2.147

Journal List > Brain Neurorehabil > v.7(2) > 1054731

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Kim, Kim, and Kim: Trial of Metoclopramide on Oro-facial Dyskinesia Following Traumatic Brain Injury: A Case Report

Case Report

Brain & Neurorehabilitation 2014; 7(2): 147-150.

Published online: 29 September 2014

DOI: https://doi.org/10.12786/bn.2014.7.2.147

Trial of Metoclopramide on Oro-facial Dyskinesia Following Traumatic Brain Injury: A Case Report

Seung Ki Kim, M.D., Joon Yeop Kim, M.D., Hyoung Seop Kim, M.D.¹

Department of Rehabilitation Medicine, Severance Hospital, Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea.

¹Department of Rehabilitation Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea.

Correspondence to: Hyoung Seop Kim, Department of Rehabilitation Medicine, National Health Insurance Service Ilsan Hospital, 100, Ilsan-ro, Ilsan-dong-gu, Goyang 410-719, Korea. Tel: 031-900-0137, Fax: 031-900-0343, rekhs@nhimc.or.kr

Received 10 September 2014 Revised 15 September 2014 Accepted 17 September 2014

Abstract

Oro-facial dyskinesia is characterized by involuntary repetitive movements of the tongue, lip, or jaw, which is known to be derived by variable causes. Pre- and post-synaptic dopamine receptor abnormalities by degenerative changes in the brain seem to be the key pathophysiology, but the exact mechanism still remained to be unknown. Metoclopramide can pass the blood-brain barrier, which is known for a selective presynaptic autoregulating dopamine D2 receptor antagonist in the brain, and is usually prescribed for dyspepsia, nausea and vomiting. In particular, it was also reported to improve the symptoms of diurnal bruxism after brain injury. With reviewing some of literatures, we present a case of 27 year old man with traumatic brain injury who showed improvement of oro-facial dyskinesia after taking oral metoclopramide.

Keywords: dopamine receptors, dyskinesias, metoclopramide

Figures and Tables

Fig. 1

Axial PET brain at 8 months from onset shows near total photon defect in the left hemisphere.

Fig. 2

FLAIR axial MRI at 9 months from the onset shows left hemisphere leukomalacia.

References

1. Blanchet PJ, Rompre PH, Lavigne GJ, Lamarche C. Oral dyskinesia: a clinical overview. Int J Prosthodont. 2005; 18:10–19.

2. Koller WC. Edentulous orodyskinesia. Ann Neurol. 1983; 13:97–99.

3. Weiner WJ, Klawans HL Jr. lingual-facial-buccal movements in the elderly. J Am Geriatr Soc. 1973; 21:314–317.

4. Bedard P, Boucher R, Di Paolo T, Labrie F. Biphasic effect of estradiol and domperidone on lingual dyskinesia in monkeys. Exp Neurol. 1983; 82:172–182.

5. Fukasawa T, Takahashi M, Otani K. A successful clonazepam treatment without tolerance in a patient with spontaneous oral dyskinesia. Prog Neuropsychopharmacol Biol Psychiatry. 2001; 25:1477–1480.

6. Rotrosen J, Adler L, Lohr J, Edson R, Lavori P. Antioxidant treatment of tardive dyskinesia. Prostaglandins Leukot Essent Fatty Acids. 1996; 55:77–81.

7. Rana AQ, Chaudry ZM, Blanchet PJ. New and emerging treatments for symptomatic tardive dyskinesia. Drug Des Devel Ther. 2013; 7:1329–1340.

8. Fudge RC, Thailer SA, Alpert M, Intrator J, Sison CE. The effects of electromyographic feedback training on suppression of the oral-lingual movements associated with tardive dyskinesia. Biofeedback Self Regul. 1991; 16:117–129.

9. Narabayashi H, Yokochi F, Nakajima Y. Idiopathic oromandibular dyskinesia treated by Vo complex microstereotactic thalamotomy. Appl Neurophysiol. 1985; 48:309–314.

10. Sutcher HD, Underwood RB, Beatty RA, Sugar O. Orofacial dyskinesia. A dental dimension. JAMA. 1971; 216:1459–1463.

11. Clark GT, Ram S. Four oral motor disorders: bruxism, dystonia, dyskinesia and drug-induced dystonic extrapyramidal reactions. Dent Clin North Am. 2007; 51:225–243. vii–ix.

12. Chen WH, Lu YC, Lui CC, Liu JS. A proposed mechanism for diurnal/nocturnal bruxism: hypersensitivity of presynaptic dopamine receptors in the frontal lobe. J Clin Neurosci. 2005; 12:161–163.

13. Yi HS, Kim HS, Seo MR. Trial of oral metoclopramide on diurnal bruxism of brain injury. Ann Rehabil Med. 2013; 37:871–874.

14. Seo MW. Four cases of senile oro-facial dyskinesia and discussion on the pathophysiology. J Korean Neurol Assoc. 1998; 16(4):458–466.

15. Kobayashi RM. Orofacial dyskinesia: Clinical features, mechanisms and drug therapy. West J Med. 1976; 125:277–288.

16. Rosengarten H, Schweitzer J, Friedhoff A. Selective dopamine D₂ receptor reduction enhances AD₁ mediated oral dyskinesia in rats. Life Sci. 1986; 39:29–35.

17. Waddington JL, O'Sullivan GJ, Tomiyama K. Regulation of orofacial movement: dopamine receptor mechanisms and mutant models. Int Rev Neurobiol. 2011; 97:39–36.

18. Tonini M, Cipollina L, Poluzzi E, Crema F, Corazza G, De Ponti F. Clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther. 2004; 19:379–390.

19. Metoclopramide-Containing Drugs. 2009. 02. 26. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumaNMedicalProducts/ucm106942.htm.

20. Rao AS, Camilleri M. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010; 31:11–19.

TOOLS

Similar articles