Journal List > Pediatr Allergy Respir Dis > v.22(3) > 1033183

Kim, Kim, Kim, Son, and Park: Clinical Manifestations of Respiratory Viruses in Hospitalized Children with Acute Viral Lower Respiratory Tract Infections from 2010 to 2011 in Busan and Gyeongsangnam-do, Korea

Abstract

Purpose

This study was performed to investigate the epidemiologic and clinical features of respiratory viruses in children with acute lower respiratory tract infection (ALRTI) in Busan and Gyeongsangnam-do, Korea.

Methods

From May 2010 to April 2011, we tested nasopharyngeal aspiration specimens in 1,520 hospitalized children with ALRTI with multiplex real time-polymerase chain reaction (RT-PCR) to identify 7 kinds of common pathogens (adenovirus [ADV], influenza virus type A [influ A], influenza virus type B [influ B], human metapneumovirus [hMPV], parainfluenza virus [PIV], human rhinovirus [hRV], respiratory syncytial virus [RSV]). We analyzed positive rates and clinical features by retrospective review of the chart.

Results

Virus agents were isolated from 72.5% of cases. The identified pathogens were RSV, 35.5%; hRV, 25.6%; PIV, 13.8%; ADV, 12.8%; hMPV, 7.1%; influ A, 5.0%; and influ B, 0.3%. The major period of viral ALRTI was the first year of life. Clinical diagnoses of viral ALRTI were pneumonia, 52.3%; bronchiolitis, 21.2%; tracheobronchitis, 1.0%; croup, 10.8%; and asthma, 8.8%. The most frequent case of pneumonia and bronchiolitis was RSV. Croup was frequently caused by PIV. The number of hMPV infections peaked between April and June and were primarily caused due to pneumonia.

Conclusion

Although this study was confined to one year, this study described the features of ALRTI associated with 7 respiratory viruses in children in Busan and Gyeongsangnam-do, Korea. Additional investigations are required to define the role of respiratory viruses in children with ALRTI in this area.

Figures and Tables

Fig. 1
Age distribution in children with acute viral lower respiratory tract infections caused by specific viruses from 2010 to 2011. ADV, adeno-virus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumo-virus; PIV, parainfluenza virus; hRV, human rhino-virus; RSV, respiratory syncytial virus.
pard-22-265-g001
Fig. 2
Monthly incidence of acute lower respiratory tract infections caused by specific viral agents from 2010 to 2011. ADV, adenovirus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumovirus; PIV, parainfluenza virus; hRV, human rhinovirus; RSV, respiratory syncytial virus.
pard-22-265-g002
Fig. 3
Distribution of viral agents according to clinical patterns in children with acute lower respiratory tract infections from 2010 to 2011. ADV, adenovirus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumovirus; PIV, parainfluenza virus; hRV, human rhinovirus; RSV, respiratory syncytial virus.
pard-22-265-g003
Table 1
Clinical Characteristics of Acute Viral Lower Respiratory Tract Infections in Children
pard-22-265-i001

Values are presented as mean±standard deviation or number (%).

ADV, adenovirus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumovirus; PIV, parainfluenza virus; hRV, human rhinovirus; RSV, respiratory syncytial virus.

References

1. Park JS. Acute viral lower respiratory tract infections in children. Korean J Pediatr. 2009. 52:269–276.
crossref
2. Acute respiratory infections in under-fives: 15 million deaths a year. Lancet. 1985. 2:699–701.
3. Lim JS, Woo SI, Kwon HI, Baek YH, Choi YK, Hahn YS. Clinical characteristics of acute lower respiratory tract infections due to 13 respiratory viruses detected by multiplex PCR in children. Korean J Pediatr. 2010. 53:373–379.
crossref
4. Choi EH, Lee HJ, Kim SJ, Eun BW, Kim NH, Lee JA, et al. The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005. Clin Infect Dis. 2006. 43:585–592.
crossref
5. Williams JV. The clinical presentation and outcomes of children infected with newly identified respiratory tract viruses. Infect Dis Clin North Am. 2005. 19:569–584.
crossref
6. Kim KH, Kim JH, Kim KH, Kang C, Kim KS, Chung HM, et al. Identification of viral pathogens for lower respiratory tract infection in children at seoul during autumn and winter seasons of the year of 2008-2009. Korean J Pediatr Infect Dis. 2010. 17:49–55.
crossref
7. Park GO, Kim JH, Lee JH, Lee JJ, Yun SW, Lim IS, et al. Epidemiologic and clinical features in children with acute lower respiratory tract infection caused by human metapneumovirus in 2006-2007. Korean J Pediatr. 2009. 52:330–338.
crossref
8. Denny FW, Clyde WA Jr. Acute lower respiratory tract infections in nonhospitalized children. J Pediatr. 1986. 108(5 Pt 1):635–646.
crossref
9. The global initiative for asthma [Internet]. [copyright year unknown]. 2006 Revision: GINA report, Global strategy for asthma management and prevention. [place unknown]: The Global Initiative For Asthma;Available from: http://www.ginasthma.org/guidelines-archived-2006-revision.html. .
10. Chai H, Farr RS, Froehlich LA, Mathison DA, McLean JA, Rosenthal RR, et al. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol. 1975. 56:323–327.
crossref
11. Lee WM, Grindle K, Pappas T, Marshall DJ, Moser MJ, Beaty EL, et al. High-throughput, sensitive, and accurate multiplex PCR-microsphere flow cytometry system for large-scale comprehensive detection of respiratory viruses. J Clin Microbiol. 2007. 45:2626–2634.
crossref
12. Park HY, Lee NY, Lee JS, Jung EH, Lee SJ, Ahn KM, et al. An epidemiological study of acute viral lower respiratory tract infections in hospitalized children from 1996 to 2002 in Seoul, Korea. Pediatr Allergy Respir Dis. 2003. 13:216–226.
13. Lee SJ, Shin EW, Park EY, Oh PS, Kim KN, Yoon HS, et al. Epidemiology and clincal analysis of acute viral respiratory tract infections in children (September, 1998-May, 2003). Korean J Pediatr. 2005. 48:266–275.
14. Park JS. Viral etiology and epidemiology of acute lower respiratory tract infections in hospitalized children (Choongchung Province in May 2001 through April 2004). Pediatr Allergy Respir Dis. 2004. 14:366–376.
15. Kim KH, Lee JH, Sun DS, Kim YB, Choi YJ, Park JS, et al. Detection and clinical manifestations of twelve respiratory viruses in hospitalized children with acute lower respiratory tract infections: focus on human metapneumovirus, human rhinovirus and human coronavirus. Korean J Pediatr. 2008. 51:834–841.
crossref
16. Park SH, Cho HJ, Shim SY, Son DW, Eun BW, Sun YH, et al. Acute respiratory infections in the neonatal intensive care unit: isolation of viruses and the characteristics of respiratory syncytial virus infection. J Korean Soc Neonatol. 2009. 16:182–189.
17. Kim CK, Choi J, Callaway Z, Kim HB, Chung JY, Koh YY, et al. Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in Seoul, Korea, 2003-2008. J Korean Med Sci. 2010. 25:342–347.
crossref
18. Wilfret DA, Baker BT, Palavecino E, Moran C, Benjamin DK Jr. Epidemiology of respiratory syncytial virus in various regions within North Carolina during multiple seasons. N C Med J. 2008. 69:447–452.
crossref
19. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995. 310:1225–1229.
crossref
20. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001. 7:719–724.
crossref
21. Chung JY, Han TH, Kim BE, Kim CK, Kim SW, Hwang ES. Human metapneumovirus infection in hospitalized children with acute respiratory disease in Korea. J Korean Med Sci. 2006. 21:838–842.
crossref
22. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004. 350:443–450.
crossref
23. Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Cote S, et al. Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis. 2002. 186:1330–1334.
crossref
24. Kaida A, Iritani N, Kubo H, Shiomi M, Kohdera U, Murakami T. Seasonal distribution and phylogenetic analysis of human metapneumo-virus among children in Osaka City, Japan. J Clin Virol. 2006. 35:394–399.
crossref
25. Yeom HH, Park JS, Jeong DJ, Kim CJ, Kim YB, Lee DH, et al. Human metapneumovirus infection in Korean children. Korean J Pediatr. 2006. 49:401–409.
crossref
26. Jartti T, van den Hoogen B, Garofalo RP, Osterhaus AD, Ruuskanen O. Metapneumovirus and acute wheezing in children. Lancet. 2002. 360:1393–1394.
crossref
TOOLS
Similar articles