Journal List > Korean J Hematol > v.43(4) > 1032795

Song, Park, Sim, Jeon, Lee, Hyun, Cho, and Park: Gullain-barre Syndrome Associated with Non-Hodgkin's Lymphoma

Abstract

A 67-year-old man developed swelling of the right leg with inguinal and abdominal pain over a period of 5 days. Excisional biopsy of the left supraclavicular lymph nodes revealed the diffuse, large B cell type of malignant lymphoma. After chemotherapy, he complained of a tingling sensation and weakness in the left upper extremity, and then this progressed to quadriplegia. Electrodiagnostic testing demonstrated the characteristic findings of demyelination, which was consistent with Guillain-Barre syndrome (GBS). Non-Hodgkin's Lymphoma (NHL) leading to GBS, as was observed in the present case, suggests that physicians should be aware of GBS and non-Hodgkin's lymphoma as the full spectrum of these dis-easeshas not been fully defined.

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Fig. 1
Magnetic resonance imaging findings demonstrating a swelling and enhancement in the 6th and 7th cervical nerve roots. (A) T1 weighted axial imaging. (B) Gadolinium enhanced T1 weighted axial imaging.
kjh-43-263f1.tif
Table 1.
Results of nerve conduction studies
Motor nerve Amplitude (mV) Right/Left DML (msec) Right/Left NCV (m/s) Right/Left
Median NA/NR NA/NR NA/NR
Ulnar NA/NR NA/NR NA/NR
Sensory nerve Amplitude (μV) Right/Left Latency (msec) Right/Left NA/NR
Median NA/5.2 NA/3.85  
Ulnar NA/2.8 NA/3.65  
Superficial radial NA/4.3 NA/2.15  
LAC NA/21.0 NA/2.20  

NCS, nerve conduction study; DML, distal motor latency; NCV, nerve conduction velocity; NR, no response; NA, not assessed; LAC, lateral antebrachial cutaneous.

Table 2.
Follow-up nerve conduction studies
Motor nerve Amplitude (mV) Right/Left DML (msec) Right/Left NCV (m/s) Right/Left
Median NR/0.2 NR/3.85 NA/NA
Ulnar NR/NR NR/NR NA/NA
Common peroneal NA/0.2 NA/3.3 NA/35.3
Tibial 1.0/0.6 6.40/6.30 31.1/36.5
Sensory nerve Amplitude (μV) Right/Left Latency (msec) Right/Left  
Median 0.9/1.2 3.5/3.55  
Ulnar 1.2/NR 3.6/NR  
Superficial radial NR/8.5 NR/1.95  
Superficial peroneal NR/NR NR/NR  
Sural NR/NR NR/NR  
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